In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

Mogrovejo-Valdivia, Alejandra; Maton, Mickaël; Garcia-Fernandez, Maria José; Tabary, Nicolas; Chai, Feng; Neut, Christel; Blanchemain, Nicolas

doi:10.3390/antibiotics10070805

Cited by 8 publications

(4 citation statements)

References 60 publications

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“…For example, Mogrovejo-Valdivia et al, designed a wound dressing loaded with silver and ibuprofen. The biomaterial displayed a sustained release of ibuprofen and antibacterial activity against E. coli and S. aureus [ 23 ]. As well as this, a new dermal device of polyvinyl alcohol (PVA) containing AgNPs associated with a collagen–hyaluronic acid membrane has been recently developed to promote skin regeneration, control inflammation, and reduce fungal and bacterial proliferation [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.

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Section: Introductionmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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“…The obtained CDs-Ag-PEM-IBU dressing released 104 μg·cm −2 (56%) of IBU-L after 30 min. Regarding the antimicrobial properties, PET-CD-Ag-PEM exhibited bacterial reduction against S. aureus and E. coli [ 118 ].…”

Section: Polysaccharides In Metal-nanoparticle-functionalized Textilesmentioning

confidence: 99%

Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

et al. 2022

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Nanotechnology is a powerful tool for engineering functional materials that has the potential to transform textiles into high-performance, value-added products. In recent years, there has been considerable interest in the development of functional textiles using metal nanoparticles (MNPs). The incorporation of MNPs in textiles allows for the obtention of multifunctional properties, such as ultraviolet (UV) protection, self-cleaning, and electrical conductivity, as well as antimicrobial, antistatic, antiwrinkle, and flame retardant properties, without compromising the inherent characteristics of the textile. Environmental sustainability is also one of the main motivations in development and innovation in the textile industry. Thus, the synthesis of MNPs using ecofriendly sources, such as polysaccharides, is of high importance. The main functions of polysaccharides in these processes are the reduction and stabilization of MNPs, as well as the adhesion of MNPs onto fabrics. This review covers the major research attempts to obtain textiles with different functional properties using polysaccharides and MNPs. The main polysaccharides reported include chitosan, alginate, starch, cyclodextrins, and cellulose, with silver, zinc, copper, and titanium being the most explored MNPs. The potential applications of these functionalized textiles are also reported, and they include healthcare (wound dressing, drug release), protection (antimicrobial activity, UV protection, flame retardant), and environmental remediation (catalysts).

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“…Additionally, nearly all the drug-release studies were carried out in the batch mode, i.e., with samples fully immersed in the release medium. As such, given that most of these volumes will be much higher than the exudate volume in contact with a WD, the drug release kinetics in vivo may be different and, as recognized by others [170], more relevant models should be employed.…”

Section: Drug Releasementioning

confidence: 99%

Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review

Guiomar

Urbano

2022

Membranes

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The prevalence of chronic, non-healing skin wounds in the general population, most notably diabetic foot ulcers, venous leg ulcers and pressure ulcers, is approximately 2% and is expected to increase, driven mostly by the aging population and the steady rise in obesity and diabetes. Non-healing wounds often become infected, increasing the risk of life-threatening complications, which poses a significant socioeconomic burden. Aiming at the improved management of infected wounds, a variety of wound dressings that incorporate antimicrobials (AMDs), namely polyhexanide (poly(hexamethylene biguanide); PHMB), have been introduced in the wound-care market. However, many wound-care professionals agree that none of these wound dressings show comprehensive or optimal antimicrobial activity. This manuscript summarizes and discusses studies on PHMB-releasing membranes (PRMs) for wound dressings, detailing their preparation, physical properties that are relevant to the context of AMDs, drug loading and release, antibacterial activity, biocompatibility, wound-healing capacity, and clinical trials conducted. Some of these PRMs were able to improve wound healing in in vivo models, with no associated cytotoxicity, but significant differences in study design make it difficult to compare overall efficacies. It is hoped that this review, which includes, whenever available, international standards for testing AMDs, will provide a framework for future studies.

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In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

Cited by 8 publications

References 60 publications

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review

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