2024
DOI: 10.1038/s41419-024-07285-2
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In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies

Emily Alefeld,
André Haase,
Dario Van Meenen
et al.

Abstract: Retinoblastoma (RB) is an intraocular tumor arising from retinal cone progenitor cells affecting young children. In the last couple of years, RB treatment evolved towards eye preserving therapies. Therefore, investigating intratumoral differences and the RB tumor microenvironment (TME), regulating tumorigenesis and metastasis, is crucial. How RB cells and their TME are involved in tumor development needs to be elucidated using in vitro models including RB derived stromal cells. In the study presented, we estab… Show more

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