in vitro Modulation of P-glycoprotein, MRP-1 and BCRP Expression by Mangiferin in Doxorubicin-Treated MCF-7 Cells

Louisa, Melva; Soediro, Tjahjani Mirawati; Suyatna, Fransiscus D.

doi:10.7314/apjcp.2014.15.4.1639

Cited by 58 publications

(45 citation statements)

References 18 publications

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“…However, these synthetic drugs might cause some adverse effects in vivo (Ieki et al, 2003;Waleed, 2007), so natural compounds are considered to be better therapeutic reagents for NPC at present. One of the promising natural compounds with anti-cancer activity and chemosensitizing activity is mangiferin (Louisa et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Mangiferin Induces Apoptosis by Regulating Bcl-2 and Bax Expression in the CNE2 Nasopharyngeal Carcinoma Cell Line

Pan¹,

Wang²,

Huang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Mangiferin Induces Apoptosis by Regulating Bcl-2 and Bax Expression in the CNE2 Nasopharyngeal Carcinoma Cell Line

Pan¹,

Wang²,

Huang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…One major mechanism that involved in drugs resistance is increased expression of multi-drug resistant MDR1, MRP1 and so on (Louisa et al, 2014). The increase of intracellular concentration of Rh-123 means silencing.…”

Section: Discussionmentioning

confidence: 99%

Alkylglyceronephosphate Synthase (AGPS) Alters Lipid Signaling Pathways and Supports Chemotherapy Resistance of Glioma and Hepatic Carcinoma Cell Lines

Zhu

Liu²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However it did not showed any significant effects on MRP1, BCRP. It was concluded that mechanism involved in anticancer activity of mangiferin was may be its inhibitory effect on P-glycoprotiens (Louisa et al, 2014).…”

Section: Natural Products In Treatment Of Breast Cancermentioning

confidence: 99%

Breast Cancer: Major Risk Factors and Recent Developments in Treatment

Majeed

Aslam²,

Javed³

et al. 2014

Asian Pacific Journal of Cancer Prevention

164

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Breast cancer is the most common in women worldwide, with some 5-10% of all cases due to inherited mutations of BRCA1 and BRCA2 genes. Obesity, hormone therapy and use of alcohol are possible causes and over-expression of leptin in adipose tissue may also play a role. Normally surgery, radiation therapy and chemotherapy allow a good prognosis where screening measures are in place. New hope in treatment measures include adjuvant therapy, neoadjuvant therapy, and introduction of mono-clonal antibodies and enzyme inhibitors.

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in vitro Modulation of P-glycoprotein, MRP-1 and BCRP Expression by Mangiferin in Doxorubicin-Treated MCF-7 Cells

Cited by 58 publications

References 18 publications

Mangiferin Induces Apoptosis by Regulating Bcl-2 and Bax Expression in the CNE2 Nasopharyngeal Carcinoma Cell Line

Mangiferin Induces Apoptosis by Regulating Bcl-2 and Bax Expression in the CNE2 Nasopharyngeal Carcinoma Cell Line

Alkylglyceronephosphate Synthase (AGPS) Alters Lipid Signaling Pathways and Supports Chemotherapy Resistance of Glioma and Hepatic Carcinoma Cell Lines

Breast Cancer: Major Risk Factors and Recent Developments in Treatment

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