In vitro modulation of tumor necrosis factor α production in THP-1 cells by lactic acid bacteria isolated from healthy human infants

Ladda, Boonyarut; Theparee, Talent; Chimchang, Juntana; Tanasupawat, Somboon; Taweechotipatr, Malai

doi:10.1016/j.anaerobe.2015.03.002

Cited by 11 publications

(16 citation statements)

References 51 publications

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“…In our study, the behavior of most lactobacilli, especially the strains L. casei MSJ1, L. casei BgShn3, and L. Casei Dwan5, was similar to that observed by Messaoudi et al [ 53 ]. Ladda et al [ 55 ] indicated that L. paracasei, L. casei, and W. confusa were tolerant to acidity and bile at pH 3.0 and 4% bile, respectively. Bujnakova et al [ 33 ] indicated that L. salivarius , L. agilis, L. reuteri , L. murinus , and L. amylovorus were tolerant to acidity and bile at pH 2.5 and 0.3% bile, respectively.…”

Section: Discussionmentioning

confidence: 99%

Isolation, Molecular Characterization and Probiotic Potential of Lactic Acid Bacteria in Saudi Raw and Fermented Milk

Masalam

Bahieldin

Alharbi

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Probiotic bacteria can confer health benefits to the human gastrointestinal tract. Lactic acid bacteria (LAB) are candidate probiotic bacteria that are widely distributed in nature and can be used in the food industry. The objective of this study is to isolate and characterize LAB present in raw and fermented milk in Saudi Arabia. Ninety-three suspected LAB were isolated from thirteen different types of raw and fermented milk from indigenous animals in Saudi Arabia. The identification of forty-six selected LAB strains and their genetic relatedness was performed based on 16S rDNA gene sequence comparisons. None of the strains exhibited resistance to clinically relevant antibiotics or had any undesirable hemolytic activity, but they differed in their other probiotic characteristics, that is, tolerance to acidic pH, resistance to bile, and antibacterial activity. In conclusion, the isolates Lactobacillus casei MSJ1, Lactobacillus casei Dwan5, Lactobacillus plantarum EyLan2, and Enterococcus faecium Gail-BawZir8 are most likely the best with probiotic potentials. We speculate that studying the synergistic effects of bacterial combinations might result in a more effective probiotic potential. We suspect that raw and fermented milk products from animals in Saudi Arabia, especially Laban made from camel milk, are rich in LAB and have promising probiotic potential.

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Section: Discussionmentioning

confidence: 99%

Isolation, Molecular Characterization and Probiotic Potential of Lactic Acid Bacteria in Saudi Raw and Fermented Milk

Masalam

Bahieldin

Alharbi

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Previous in vitro studies showed an antimicrobial and anti-inflammatory effect of L. paracasei. 14,18 Among many studies exploring the efficacy of the The pathogenesis of the acne, C. acnes, and inflammatory process played an essential role in causing acne lesions. 3,19 Previous studies indicated dried cell-free supernatant of L. paraplantarum THG-G10 could inhibit the proliferation of C. acnes and inhibit nitric oxide production.…”

Section: Ta B L E 1 Baseline Characteristic Of the Patientsmentioning

confidence: 99%

“…Moreover, our study confirmed the ability of L. paracasei MSMC 39-1 to inhibit TNFα, stimulated by human monocytes, which was one of the critical proinflammatory cytokines associated with acne pathogenesis, in line with the previous data. 14 Antimicrobial and anti-inflammatory substances produced from this probiotic were generally secreted into broth medium, also known as supernatant. Then, the probioticderived lotion made from the supernatant was formulated and applied to facial acne patients.…”

Section: Ta B L E 1 Baseline Characteristic Of the Patientsmentioning

confidence: 99%

“…13 From our published data, in vitro study revealed that cell-free culture supernatant of isolates Lactobacillus paracasei (L. paracasei) MSMC 39-1, L. casei MSMC39-3, and Weissella confusa MSMC57-1 can decrease TNFα levels which was proinflammatory cytokine and the most significant inhibitory effect on TNFα production were found in supernatants of L. paracasei MSMC 39-1. 14 Consequently, we hypothesized the potential use of topical probiotic-derived lotion to the treatment of acne vulgaris due to its anti-inflammatory property. Therefore, this study aims to evaluate the efficacy and safety of topical probiotic-derived lotion from L. paracasei MSMC 39-1 for treating mild-to-moderate acne vulgaris patients.…”

Section: Introductionmentioning

confidence: 99%

“…casei MSMC39‐3, and Weissella confusa MSMC57‐1 can decrease TNF‐α levels which was proinflammatory cytokine and the most significant inhibitory effect on TNF‐α production were found in supernatants of L . paracasei MSMC 39‐1 14 . Consequently, we hypothesized the potential use of topical probiotic‐derived lotion to the treatment of acne vulgaris due to its anti‐inflammatory property.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of probiotic‐derived lotion from Lactobacillus paracasei MSMC 39‐1 in mild to moderate acne vulgaris, randomized controlled trial

Sathikulpakdee

Kanokrungsee

Vitheejongjaroen

et al. 2022

J of Cosmetic Dermatology

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Background: Probiotics provide benefits for reducing acne. Previous studies showed an anti-inflammatory effect of Lactobacillus paracasei. However, the clinical evidence of topical probiotic lotion and acne treatment is still lacking.Objective: To evaluate the efficacy and safety of probiotic-derived lotion compared with 2.5% benzoyl peroxide in the treatment of mild-to-moderate acne vulgaris.Methods: Topical probiotic-derived lotion was formulated from cell-free supernatant of L. paracasei MSMC 39-1. In vitro study showed the ability of the supernatant to inhibit both antibiotic-resistance and-susceptibility strains of C. acnes and inhibit tumor necrosis factorα. The patients with mild-to-moderate acne vulgaris on the face were randomized to receive topical probiotic-derived lotion or 2.5% benzoyl peroxide. Acne lesion counts, erythema index, and side effects were assessed after 2 and 4 weeks of treatment.Results: One hundred and four acne vulgaris patients were enrolled. After four weeks of treatment, the inflammatory acne lesion counts and erythema index significantly decreased compared with the baseline in both the probiotic-derived lotion group and 2.5% benzoyl peroxide group (p < 0.001 in both groups) without statistically significant difference between the two groups (p > 0.05). However, the comedones were not affected in both groups. Four patients (7.69%) treated with probiotic-derived lotion and 14 patients (26.92%) treated with 2.5% benzoyl peroxide reported treatmentassociated side effects. Conclusion:Probiotic-derived lotion is safe and effective for treating mild to moderate acne vulgaris, a comparable outcome with 2.5% benzoyl peroxide. It could be an alternative treatment of acne with more minor side effects.

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Hepatoprotective Effect of Probiotic Lactic Acid Bacteria on Thioacetamide-Induced Liver Fibrosis in Rats

Jantararussamee

Rodniem

Taweechotipatr

et al. 2020

Probiotics & Antimicro. Prot.

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In vitro modulation of tumor necrosis factor α production in THP-1 cells by lactic acid bacteria isolated from healthy human infants

Cited by 11 publications

References 51 publications

Isolation, Molecular Characterization and Probiotic Potential of Lactic Acid Bacteria in Saudi Raw and Fermented Milk

Isolation, Molecular Characterization and Probiotic Potential of Lactic Acid Bacteria in Saudi Raw and Fermented Milk

Efficacy of probiotic‐derived lotion from Lactobacillus paracasei MSMC 39‐1 in mild to moderate acne vulgaris, randomized controlled trial

Hepatoprotective Effect of Probiotic Lactic Acid Bacteria on Thioacetamide-Induced Liver Fibrosis in Rats

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