In vitro nematocidal activity of Punica granatum L. against gastrointestinal helminths in goats

Felix, Renata Cristinne da Silva; Barbosa, Tallyson Nogueira; Marques, Higor Peixoto; Rebouças, Cristina Karine de Oliveira; Pereira, José Carlos da Silveira; Batista, João Inácio Lopes; Soares, Karoline Mikaelle de Paiva; Silva, Michele Dalvina Correia da; Bezerra, Ana Carla Diógenes Suassuna

doi:10.1007/s12639-021-01439-1

Cited by 2 publications

(4 citation statements)

References 45 publications

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“…Moreover, the efficacy of the PPE was investigated in vivo with GINs in sheep (Kaiaty et al 2021 ), detecting a 97% decrease in eggs in feces by the 21st day. Previous trials by da Silva Felix et al ( 2022 ) ascertained the ovicidal effect of P. granatum peel salt extract, which held key secondary metabolites and revealed non-toxic responses at the lowest concentration tested. In addition, Kaiaty et al ( 2021 ) found that PPE presented anthelmintic activities in various ruminant species, such as cattle, buffalo, sheep, and goats, when compared to synthetic anthelmintics.…”

Section: Discussionmentioning

confidence: 99%

“…A pomegranate-based compound has been recommended to reduce gastrointestinal nematode (GIN) egg production by 50%, aligning with the sustainable and complementary green veterinary pharmacology (GVP) approach that aims to reduce chemical use and counteract anthelmintic resistance (Castagna et al 2021 ). Studies have demonstrated the effect of methanol extracts of pomegranate fruit peels on larval motility and the egg hatchability rate of H. contortus parasites (Jabeen et al 2015 , Da Silva Felix et al 2022 ) (Ahmed et al 2020 ; Castagna et al 2020 ). However, challenges such as efficacy variability, potential resistance, limited availability, and potential antinutritional effects need to be addressed (Athanasiadou et al 2007 ; Jamil et al 2022 ; Valladão et al 2015 ) .…”

Section: Introductionmentioning

confidence: 99%

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Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus

Kaiaty,

Salib,

El-Gameel

et al. 2023

Trop Anim Health Prod

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Haemonchus contortus (H. contortus) is one of the most prevalent gastrointestinal nematodes, causing health problems and economic losses in ruminants. Nanotechnology holds great promise as a field of science, with potential applications in veterinary medicine. This study investigated the in vitro anthelmintic activity of silver nanoparticles (AgNPs), selenium nanoparticles (SeNPs), and pomegranate peel extract (Punica granatum; PPE) on different stages of H. contortus: eggs, larvae, and adults. The in vitro anthelmintic efficacy was evaluated using the egg hatching inhibition assay (EHA), the third larval stage paralysis assay (LPA), and the adult worm motility inhibition assay (WMI). Six dilutions of PPE were utilized for EHA, LPA, and WMI, ranging from 0.25 to 6 mg/ml. AgNPs dilutions ranged from 0.00001 to 1.0 μg/ml for EHA and LPA and 1 to 25 μg/ml for WMI. SeNPs were utilized at dilutions of 1, 5, 10, and 15 μg/ml for EHA, LPA, and WMI. The results showed that the lowest concentration of AgNPs, SeNPs, and PPE significantly inhibited egg hatching. To further assess larvicidal activity, AgNPs at the highest concentration of 1 μg/ml induced a strong larvicidal effect, as did SeNPs at the lowest concentration. On the contrary, PPE displayed a significant larvicidal effect at 1 mg/ml compared to the control. The percentage mortality of adult H. contortus was measured as follows (mortality (%) = the number of dead adult H. contortus/total number of adult H. contortus per test × 100). The death of the adult H. contortus was determined by the absence of motility. Adult H. contortus mortality percentage was also significantly affected by all three agents when compared to the control. The AgNPs, SeNPs, and PPE have effective antiparasitic activity on gastrointestinal parasitic nematodes. These results provide evidence of the excellent antiparasitic properties of AgNPs, SeNPs, and PPE, demonstrating their effectiveness in controlling eggs, larvae, and adult H. contortus in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus

Kaiaty,

Salib,

El-Gameel

et al. 2023

Trop Anim Health Prod

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“…of 6.19 mg mL-1. (20) Punicalagin had better anticoccidial effects. The results of Elisa's studies on anticoccidial mechanisms, antioxidant studies, and pathological observations show that punicalagins alleviated appendicitis, improved immunoglobulin expression in cecal tissue, improved cecal integrity, and that her Indicates that the redox state has been restored.…”

Section: Antiparasitic Activitymentioning

confidence: 91%

“…Recent years have seen increased interest on the part of consumers, researchers, and natural products in how natural products can help maintain health; and the role that crude drugs play in the prevention and treatment of many illnesses has become widely accepted). Physiological benefits of pomegranate play an important role in disease prevention or slow the progress of chronic diseases (cancer (antioxidant effect on tumours and prevention of invasion), microbial, fungal and parasitic infections, diabetes Miletus (amylases inhibitors), anti-viral (its prophylactic effect against COVID 19) (7-9, [13][14][15][16][17][18][19][20].…”

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confidence: 99%

Pomegranates bioactive metabolites and biological activities: an updated review

Abdelkarim

Ebrahim

Eissa

et al. 2023

ERU Research Journal

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Pomegranate (Punica granatum L.) is a fruit that is widely consumed as fresh fruit and juice. The use of pomegranate fruit dates from ancient times and literature about its therapeutic qualities has echoed throughout the ages. Several in vitro and in vivo studies have shown how this fruit acts as antioxidant, antidiabetic, and hypolipidemic and shows antibacterial, antiparasitic antifungal, anti-including primarily hydrolysable ellagitannins, anthocyanins, sugars, organic acids and other polyphenols. The aim of this review is to present an updated overview of the functional, medical, chemical and physiological properties of this fruit &/or its agri-food residues aiming to figure out the significance of pomegranates.

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In vitro nematocidal activity of Punica granatum L. against gastrointestinal helminths in goats

Cited by 2 publications

References 45 publications

Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus

Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus

Pomegranates bioactive metabolites and biological activities: an updated review

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