To compare rotational stability and its influencing factors in 3 different widely used hydrophobic acrylic intraocular lenses (IOLs) from the end of surgery (EoS) to 4-7 months (6 months) in over 380 eyes.DESIGN: Prospective interventional comparative clinical study.METHODS: Setting: Department of Ophthalmology, Medical University of Vienna. Patient population: A total of 381 eyes of 199 patients with age-related cataract received an IOL Acrysof SN60WF, Tecnis ZCB00, or Envista MX60 in a consecutive order. Intervention: Implantation of an Acrysof, Tecnis, or Envista IOL randomized to the 0 ± 10, 45 ± 10, 90 ± 10, or 135 ± 10 8 axis in 1 or both eyes. Baseline measurement was performed with patients supine still on the operating table. Postoperative follow-ups were conducted after 1 hour, 1 week, 1 month, and 6 months. Main outcome measures: Difference of absolute rotation from the EoS to 6 months.RESULTS: Absolute rotations from the EoS to 6 months were 1.65 ± 2.1, 2.65 ± 4.1, and 3.18 ± 5.8 8 for the Acrysof, Tecnis, and Envista group, respectively. Rotational stability was statistically significantly superior in the Acrysof compared with the Envista group (P [ .014), but not compared with the Tecnis group (P [ .10). No significant difference was found between the Tecnis and Envista groups (P [ .761). Maximum values of 15.8, 38.6, and 44.9 8 were observed for the Acrysof, Tecnis, and Envista group, respectively.CONCLUSION: The Acrysof IOL showed the least amount of absolute rotation compared with the Tecnis and Envista IOLs. Outliers possibly requiring secondary intervention were observed in all groups. The amount of rotation was greatest during the first postoperative hour.