In Vitro Parameters of Cell‐mediated Immune Reactions in Healthy Individuals Following Immune‐stimulation Attempts With Levamisole

Thulin, H; Thestrup‐Pedersen, Kristian; Ellegaard, Jørgen

doi:10.1111/j.1398-9995.1974.tb02692.x

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…This was performed as described by Clausen (1973), but instead of using the standard procedure, CO2/bicarbonate buffered agarose medium was substituted by HEPESbuffered medium (Thulin, Thestrup-Pedersen, and Ellegaard, 1975).…”

Section: Leucocyte Migration Test (Lmt)mentioning

confidence: 99%

Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests.

From¹,

Thestrup‐Pedersen²,

Thulin³

1976

Sexually Transmitted Infections

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Section: Leucocyte Migration Test (Lmt)mentioning

confidence: 99%

Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests.

From¹,

Thestrup‐Pedersen²,

Thulin³

1976

Sexually Transmitted Infections

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“…Many investigators have reported on the immune stimulatory effects of levamisole in specific antigen-stimulated (Copeland et ai., 1974;Litehenfeld et al, 1976;Pabst et al;1975 Thulin et al), and mitogen-stimulated (Merluzzi et al, 1975 andSampson et al, 1976) lymphocytes in vitro. Similar immunostimulatory effects have also been reported to occur i_nn vivo (Van Heuk et al, 1976a=d Verhaegen et al, 1973.…”

Section: Introductionmentioning

confidence: 94%

Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses inMycobacterium bovis sensitized lymphocyties

et al. 1979

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A study was conducted to determine the kinetics of levamisole-induced potentiation of lymphocyte blastogenesis in Mycobacteriumbovis sensitized and nonsensitized cattle lymphocytes. It was observed that levamisole significantly potentiated PPDinduced blastogenic responses when it (levamisole) was added to M.~ boris sensitized lymphocyte cultures 24 hours prior to the addition of PPD. Levamisole-indueed either minimal or suppressed the PPD-induced lymphocyte stimulation response in M. boris nonexposed control lymphocytes. The implications of~ossib!e use of levamisole in cellular in vitro assays for studying anergy or general unresponsiveness are discussed.

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“…The leucocvte migration test was performed using an agarose technique as described elsewhere (19). Leucoc>ies were suspended in Hepes-buffered tissue culture medium (TC-199) with: a) 10 per cent pooled AB serum and PPD, b) 10 per cent pooled AB serum and 0.9 per cent saline.…”

Section: Leucocyte Migration Testmentioning

confidence: 99%

Long‐term Transfer Factor Treatment in Severe Atopic Dermatitis

Thulin

Ellegaard

Thestrup‐Pedersen

et al. 1977

Allergy

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Since Lawrence demonstrated that delayed hypersensitivity reactions in man could be transferred by viable leucocytes or extracts hereof, called transfer factor (TF) (lo), attempts to augment cell-mediated immune functions with TF have been made on patients with deficient cell-mediated immune reactivity. The main fields in which the clinical application of TF is used are infectious diseases (6, 9), immunodeficiency diseases (15) and malignancies (11, 20).In dermatology TF has been successfully used to intensify parameters of cell-mediated immune reactions in a patient with severe skin infection caused by Mycobacterium avium (17); also in generalized vaccinia treatment with TF seems to be of value (5). In mycosis fungoides additional treatment with TF was found promising (21).Within the last year two case reports have indicated a very successful use of TF in the treatment of severe atopic dermatitis in children (i, 16). We have treated three adults with severe atopic dermatitis and signs of depressed cell-mediated immune reactivity for a period of i V2 years. The present paper gives our results.

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In Vitro Parameters of Cell‐mediated Immune Reactions in Healthy Individuals Following Immune‐stimulation Attempts With Levamisole

Cited by 11 publications

References 11 publications

Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests.

Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests.

Kinetics of levamisole-induced potentiation of lymphocyte blastogenic responses inMycobacterium bovis sensitized lymphocyties

Long‐term Transfer Factor Treatment in Severe Atopic Dermatitis

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