In Vitro Phytochemical, Antioxidant, and Antibacterial Evaluations of Various Extracts of Eleocharis dulcis (Burm.f.) Trin. ex Hensch

doi:10.26538/tjnpr/v7i5.11

Cited by 3 publications

(2 citation statements)

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“…The major classes of phytochemical constituents present in the various leaf extracts were determined according to established methods. 32…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Comparative Acute Oral Toxicity of Landolphia owariensis P. beauv. Leaf Extracts in Wistar Rats

2023

TJNPR

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IntroductionLandolphia owariensis is a climbing herb belonging to the family Apocynaceae. It is well distributed from Guinea to West Cameroon and extends across Central Africa to Sudan, Uganda, and Southern Tanganyika. 1 Of the sixty (60) known species of the Landolphia genus, Landolphia owariensis is recognized as one of the most studied and useful species. 2 It is known as "panukuru" in the Yoruba Language. 3 Microscopic examination of the powdered leaves of L. owariensis showed stomatal cells, starch grains, and fibers are present. 4 Studies on its pharmacological properties have shown it to have a host of diverse activities including antioxidant, 5,6 antiulcer, and antisecretory effects with the leaves. 7 The aqueous, methanol, and chloroform leaf extracts have shown anti-inflammatory and analgesic properties 8 while the ethanol extract of the leaf and root showed antimicrobial activities. 9-11 Similar antimicrobial activity has also been established with the fruits. 12 The root is soaked in local gin and given for the treatment of gonorrhea. 13

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“…The major classes of phytochemical constituents present in the various leaf extracts were determined according to established methods. 32…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Comparative Acute Oral Toxicity of Landolphia owariensis P. beauv. Leaf Extracts in Wistar Rats

2023

TJNPR

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“…The crude ethanol extract of V. heyneana stems was tested for the presence of carbohydrates, essential oils, amino acids, fats, steroids, cardiac glycosides, triterpenoids, saponins, tannins, flavonoids, alkaloids, coumarins, and polyuronides. The qualitative analysis of these phytoconstituents was performed using standard protocols as reported by Amalia et al 25 and Van Chen et al 26 with slight modifications.…”

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

Phytochemical Screening, Antioxidant and Xanthine Oxidase Inhibitory Activities of Vitis heyneana Schult. Stem Extracts From Vietnam

2023

TJNPR

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Generally, these agents have the ability to oxidize proteins, lipids, and nucleic acids and produce hazardous byproducts. These byproducts can cause cellular damage, such as changes in membrane structure, damage to organelles, damage to DNA, and dysfunction of cells, in addition to a number of serious illnesses (e.g., diabetes, hypertension, gouty inflammation, dyslipidemia, atherosclerosis, etc.). 4,[8][9][10] Previous reports have demonstrated that gout is associated with comorbidities such as hypertension, renal disease, diabetes mellitus, metabolic syndrome, hyperlipidemia and atherosclerosis, cancer, and aging. 2,11 Therefore, antioxidant therapy using bioactive compounds that inhibit XO activity is frequently suggested as an effective method to prevent gout complications and related ailments. Xanthine oxidase inhibitors (XOIs) e.g., allopurinol, topiroxostat, febuxostat, and pyranostat are a class of medications used for lowering uric acid level in the management of gout. 12,13 Allopurinol, introduced in 1966, is the most commonly used drug to lower urate levels in serum and urine. 14 It has been shown to be effective in reducing flares and tophi as urate levels decrease, reducing cardiovascular mortality, the risk of developing chronic kidney disease, the risk of prostate cancer, [15][16][17] as well as anti-inflammatory, and analgesic effects. 12 However, due to the long-term treatment, allopurinol may lead to many adverse effects including gastrointestinal bleeding, renal toxicity, 5,18 hypersensitivity syndrome and rashes, 13 toxic epidermal necrolysis syndrome, and liver function abnormalities. 5 Therefore, the search for new XO inhibitors, especially natural compounds, is still necessary. Studies have reported that bioactive compounds such as polyphenols (e.g., flavonoids, tannins, and coumarins), saponins, terpenoids, and alkaloids showed uric acid-lowering effects and were effective in inhibiting XO. 19,20 Furthermore, these compounds may also contribute to the improvement of gout by impeding oxidative stress. 20 The genus Vitis L. (belonging to the family Vitaceae) contains 81 accepted species, 21 and they are well known for their many uses in

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The Single Compound Isolate of Eleocharis dulcis having the Antibacterial activity on Fish Diseases

Amalia,

Fitri Isma Nugraha,

Elya

2024

RJPT

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Eleocharis dulcis (Burm.f.) Trin. ex. Hensch. has been used a lot in traditional treatment in China to cure coughing, laryngitis, hepatitis, enteritis, hypertension, and pharyngitis. This research aims to identify the extracts, fractions, and isolates of the active E. dulcis toward the antioxidant and antibacterial activities. The extraction was conducted in levelling (hexane, ethyl acetate, and methanol) by using the method of Ultrasonic Assisted Extraction (UAE). The antibacterial activity was tested against the bacteria causing fish diseases, such as Aeromonas hydrophila, Aeromonas salmonicida, and Streptococcus agalactiae. Minimum Inhibitory Concentration (MIC) was carried out by microdilution and the Minimun Bactericidal Concentration (MBC) being determined by growing the microdilution solution. The antioxidant activity test was conducted with the method of DPPH. The active fraction in the fractionation with column chromatography, and furthermore the antioxidant and antibacterial activities were tested. The active isolate was identified with LCMS, 1H-NMR, 13C-NMR, and HMBC. The fractionation of the N-Hexane (NH) extract produced 6 derivative fractions, but there is no single compound isolate. Meanwhile, the Ethyl Acetate (EA) fraction produced 8 derivative fractions. From the Ethyl Acetate no 1(EA1) fraction there is a single isolate identified as the stigmasterol compound. The stigmasterol compound does not show the antioxidant activity, but it has the antibacterial activity. The stigmasterol compound has the antibacterial activity at the concentration of 62.5ppm toward the bacterium of Aeromonas hydrophila, 125ppm toward the bacterium of Aeromonas salmonicida, and 3.25ppm toward the bacterium of Streptococcus agalactiae. Correlated with the positive control, chloramphenicol antibiotic has the antibacterial activity at the concentration of 30ppm. The research results of the N-Hexane fraction do not identify that there is a single isolate. The conclusion of the Ethyl Acetate fraction shows that there is a single isolate which is the stigmasterol compound having the antibacterial activity on fish diseases that can be developed further for the treatment of the bacteria causing the fish diseases.

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In Vitro Phytochemical, Antioxidant, and Antibacterial Evaluations of Various Extracts of Eleocharis dulcis (Burm.f.) Trin. ex Hensch

Cited by 3 publications

References 21 publications

Comparative Acute Oral Toxicity of Landolphia owariensis P. beauv. Leaf Extracts in Wistar Rats

Comparative Acute Oral Toxicity of Landolphia owariensis P. beauv. Leaf Extracts in Wistar Rats

Phytochemical Screening, Antioxidant and Xanthine Oxidase Inhibitory Activities of Vitis heyneana Schult. Stem Extracts From Vietnam

The Single Compound Isolate of Eleocharis dulcis having the Antibacterial activity on Fish Diseases

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