In vitro prediction of clinical signs of respiratory toxicity in rats following inhalation exposure

Silva, E. Da; Hickey, Christina; Ellis, Graham; Hougaard, Karin Sørig; Sørli, Jorid B.

doi:10.1016/j.crtox.2021.05.002

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Narrative Review Of Lung Surfactant As a Toxicological Model1

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Cited by 12 publications

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“…Three industrial chemicals (used in coatings, solvents, and fragrances) known to have acute inhalation toxicity were evaluated for potential LS toxicity. An array of techniques was utilized including CDS, CBS, LBT, Cryo-TEM, and DSC ( Da Silva et al, 2021b ). Inhibition of LS was related to partial fluidization of condensed phases by insertion between phospholipids, resulting in reduced stability and cohesion.…”

Section: Narrative Review Of Lung Surfactant As a Toxicological Modelmentioning

confidence: 99%