In vitro properties of a chitosan-bonded hydroxyapatite bone-filling paste

Design of ceramic-based cements and putties for bone graft substitution

“…These were followed by more than a dozen other commercial CPC formulations (Table 2). Recently, efforts towards composites of hydrogels and bone substitutes (Chan et al, 2002;Chazono et al, 2004;Dupraz et al, 1998;Grimandi et al, 1998;Ito, 1991;Maruyama et al, 1995;Momota et al, 2002;Pompili et al, 1998) have been intensified and several products have been launched (Table 3). These efforts are expressed by a rapid increase of the number of publications.…”

Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests

“…This mineral can be regarded, with some limitations, as a crystallochemical analogue of the main mineral constituent of human and animal skeletal tissues [6]. A wide range of biomaterials for different clinical applications can be created on the basis of two components: nanocrystalline apatite and chitosan [3][4][5][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Chitin is the second (after cellulose) most abundant natural polysaccharide.…”

The effect of combination of rhBMP-4 and chitosan on the regeneration of bone defects

“…조직과 유사한 결합형태로 생체흡수성, 생체적합성 11,12) 및 항미생물 작용 13) , 창상치유촉진 14) , 지혈작 용 15) , 골전도성 11,16,17) II. 연구재료 및 방법 There were enlarged vessels in the center area and dense connective tissue was stained strongly, but new bone formation was not observed.…”