In vitro release profiles of β-carotene encapsulated in PHBV by means of supercritical carbon dioxide micronization technique

Priamo, Wagner Luiz; Cezaro, Alana Marie de; Benetti, Stéphani C.; Oliveira, J. Vladimir; Ferreira, Sandra R.S.

doi:10.1016/j.supflu.2010.12.013

Cited by 23 publications

(13 citation statements)

References 17 publications

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“…The suspensions of coprecipitated into anhydrous ethanol were manually agitated for about 20 s and then all samples were filtered using a membrane filter with porosity of 0.22 m (Millipore, model FGLP). After filtration, the material retained was dried under controlled temperature (303 K) and vacuum for 24 h (Priamo et al, 2010(Priamo et al, , 2011Franceschi et al, 2008aFranceschi et al, ,b, 2009). Afterwards, the dried powder was dissolved in dichloromethane and the solution was analyzed in a spectrophotometer (Shimadzu, model UVmini 1240).…”

Section: Analysis and Characterizationmentioning

confidence: 99%

“…For in vitro release assays it was used a procedure similar to the one previously described by Lionzo et al (2007) and by Priamo et al (2011). The particles resulting from the co-precipitation step were submitted to a fast washing step to remove the non-encapsulated (excess, free) bixin, as previously discussed.…”

Section: In Vitro Release Experimentsmentioning

confidence: 99%

“…All tests were performed in 125 mL Erlenmeyers flasks (protected at the top with plastic wrap to prevent solvent evaporation), placed in a refrigerated incubator shaker (Tecnal, model TE-424) at 301.15 K ± 1 K and 120 rpm. At scheduled time intervals, a 3.0 mL sample was collected and immediately replenished with pure solvent to maintain the original volume (Priamo et al, 2011). Before performing the UV-visible spectrophotometer (Shimadzu, model UVmini 1240) analysis (in triplicate), the solution collected was filtered through a membrane filter with porosity of 0.22 m (Millipore, model FGLP).…”

Section: In Vitro Release Experimentsmentioning

confidence: 99%

“…For instance, Priamo et al (2011) reported in vitro release profiles of ␤-carotene encapsulated in PHBV in four solvents and concluded that in general, the ␤-carotene release can be controlled by the organic solvent used and by the initial amount of solute encapsulated (loading). Also, Wang et al (2009) investigated the behavior of poly(-caprolactone) (PCL) microspheres loaded by two model compounds (p-nitroaniline and rhodamine B) and noted that for the assay performed in PBS buffer (pH 7.4) at 310.15 ± 1 K, both active principles presented cumulative release nearly 80% after 5 days.…”

Section: In Vitro Release Of Bixinmentioning

confidence: 99%

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Encapsulation of bixin in PHBV using SEDS technique and in vitro release evaluation

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Section: Analysis and Characterizationmentioning

confidence: 99%

Section: In Vitro Release Experimentsmentioning

confidence: 99%

Section: In Vitro Release Experimentsmentioning

confidence: 99%

Section: In Vitro Release Of Bixinmentioning

confidence: 99%

See 2 more Smart Citations

Encapsulation of bixin in PHBV using SEDS technique and in vitro release evaluation

Boschetto

Aranha

Souza

et al. 2014

Industrial Crops and Products

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“…Successive studies on β-carotene-and astaxanthin-PHBV SEDS produced nanoparticulates (Machado Jr et al, 2014;Priamo et al, 2011;Priamo et al, 2010) confirmed that the encapsulation efficiency and the percentage of carotenoids entrapped in the polymeric matrix were maximal at highest pressure (20 and 10 MPa, respectively) and carotenoid concentration in the organic solution (~1:1 and 1:2 β-carotene and astaxanthin to PHBV ratio). β-Carotene release in the organic phase depended on the used solvent type (being faster for ethyl acetate and n-hexane than for ethanol) and the loaded bioactive amount (Priamo et al, 2011).…”

mentioning

confidence: 79%

A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids

Soukoulis

Bohn

2017

Critical Reviews in Food Science and Nutrition

209

135

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Carotenoids are lipophilic secondary plant compounds, and their consumption within fruits and vegetables has been positively correlated with a decreased risk of developing several chronic diseases. However, their bioavailability is often compromised due to incomplete release from the food matrix, poor solubility and potential degradation during digestion. In addition, carotenoids in food products are prone to oxidative degradation, not only lowering the nutritional value of the product but also triggering other quality deteriorative changes, such as formation of lipid pro-oxidants (free radicals), development of discolorations or off-flavor defects. Encapsulation refers to a physicochemical process, aiming to entrap an active substance in structurally engineered micro- or nano-systems, in order to develop an effective thermodynamical and physical barrier against deteriorative environmental conditions, such as water vapor, oxygen, light, enzymes or pH. In this context, encapsulation of carotenoids has shown to be a very effective strategy to improve their chemical stability under common processing conditions including storage. In addition, encapsulation may also enhance bioavailability (via influencing bioaccessibility and absorption) of lipophilic bioactives, via modulating their release kinetics from the carrier system, solubility and interfacial properties. In the present paper, it is aimed to present the state of the art of carotenoid microencapsulation in order to enhance storability and bioavailability alike.

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Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

233

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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In vitro release profiles of β-carotene encapsulated in PHBV by means of supercritical carbon dioxide micronization technique

Cited by 23 publications

References 17 publications

Encapsulation of bixin in PHBV using SEDS technique and in vitro release evaluation

Encapsulation of bixin in PHBV using SEDS technique and in vitro release evaluation

A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

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