In Vitro Release Testing of Semi-Solid Dosage Forms

Kanfer, Isadore; Rath, Seeprarani; Purazi, Potiwa; Mudyahoto, Nyengeterai Amanda

doi:10.14227/dt240317p52

Cited by 24 publications

(12 citation statements)

References 55 publications

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“…Various dimensions are described with orifice diameter, receptor volume, and donor chamber size being the most critical to understand to keep variability as low as possible. During the last 20 years, various publications have reviewed various aspects and applications of IVRT as a tool to support topical product development, from scale-up and post-approval changes for non-sterile semisolid dosage forms (SUPAC-SS) to the more recently proposed topical drug classification system (TCS) (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

In Vitro Release Testing Methodology and Variability with the Vertical Diffusion Cell (VDC)

Klein¹,

Heckart²,

Thakker³

2018

Dissolution Technol.

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In vitro release test (IVRT) using the vertical diffusion cell (VDC) is a well-established method to evaluate the performance of a topical dosage form and to better understand the physicochemical characteristics of the product. The VDC is the most frequently used apparatus to measure drug release from semisolid products and has been in use for more than fifty years; however, the technique is often hampered by high variability and inadequate reproducibility. Various method parameters influence drug release and the associated variation of the release profiles. The purpose of this manuscript is to examine the critical parameters of the VDC apparatus and the methods that are developed using it, and to highlight potential sources of variability that must be well understood to develop, validate, and implement highly effective VDC methods.

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mentioning

confidence: 99%

In Vitro Release Testing Methodology and Variability with the Vertical Diffusion Cell (VDC)

Klein¹,

Heckart²,

Thakker³

2018

Dissolution Technol.

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“…In vitro release tests are valuable tools for monitoring the release of active substances from semisolid formulations following product development and quality control [ 97 ]. In the relevant pharmacopoeias there are no compendial apparatus, procedures or requirements for in vitro release testing [ 98 ].…”

Section: Evaluation Of Ocular In Situ Gels Based On Chitosanmentioning

confidence: 99%

Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review

et al. 2018

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Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged contact time of ointments. Chitosan is a natural polymer suitable for use in ophthalmic formulations due to its biocompatibility, biodegradability, mucoadhesive character, antibacterial and antifungal properties, permeation enhancement and corneal wound healing effects. The combination of chitosan, pH-sensitive polymer, with other stimuli-responsive polymers leads to increased mechanical strength of formulations and an improved therapeutic effect due to prolonged ocular contact time. This review describes in situ gelling systems resulting from the association of chitosan with various stimuli-responsive polymers with emphasis on the mechanism of gel formation and application in ophthalmology. It also comprises the main techniques for evaluation of chitosan in situ gels, along with requirements of safety and ocular tolerability.

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“…Chitin-Chitosan -Myriad Functionalities in Science and Technology the lenses, and for the inserts and the contact angle [101]. Measuring the degree of drug release in vitro is vital in the development of a pharmaceutical product, the best known way being with Franz's diffusion cell [102,103] In a Franz cell, consisting of two compartments separated by an artificial membrane and filled with simulated biological fluid, the formulation to be analyzed is placed. Holding at 37 C, samples are taken at certain time intervals and analyzed to determine the concentration of the substance that crossed the membrane [104].…”

Section: Advanced Drug Delivery Technologiesmentioning

confidence: 99%

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Popa¹,

Ghica²,

Dinu-Pîrvu³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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This chapter focuses on the eye, one of the most important organs of humans. Current data on pathophysiology of the human eye are presented in direct correlation with a range of therapeutic products, with a well-known and widely used material, namely chitosan. Applications of chitosan biopolymer are described in the development of innovative, modern, therapeutic devices and solutions. Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants. A number of disadvantages for ocular administration of the drugs are thus overcome.

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In Vitro Release Testing of Semi-Solid Dosage Forms

Cited by 24 publications

References 55 publications

In Vitro Release Testing Methodology and Variability with the Vertical Diffusion Cell (VDC)

In Vitro Release Testing Methodology and Variability with the Vertical Diffusion Cell (VDC)

Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

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