In vitro remineralization of primary teeth with a mineralization-promoting peptide containing dental varnish

Tulumbacı, Fatih; Gungormus, Mustafa

doi:10.1590/1678-7757-2020-0259

Cited by 13 publications

(27 citation statements)

References 41 publications

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“…al., used a peptide with eight repetitive sequences of aspartate-serine-serine (8DSS) as a mineralization agent in a rat model [ 37 ]. A recent study incorporated a mineral-promoting peptide within a resin varnish system to enhance local remineralization on extracted primary teeth [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives

Yuca

Xie

Song

et al. 2021

IJMS

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Resin-based composite materials have been widely used in restorative dental materials due to their aesthetic, mechanical, and physical properties. However, they still encounter clinical shortcomings mainly due to recurrent decay that develops at the composite-tooth interface. The low-viscosity adhesive that bonds the composite to the tooth is intended to seal this interface, but the adhesive seal is inherently defective and readily damaged by acids, enzymes, and oral fluids. Bacteria infiltrate the resulting gaps at the composite-tooth interface and bacterial by-products demineralize the tooth and erode the adhesive. These activities lead to wider and deeper gaps that provide an ideal environment for bacteria to proliferate. This complex degradation process mediated by several biological and environmental factors damages the tooth, destroys the adhesive seal, and ultimately, leads to failure of the composite restoration. This paper describes a co-tethered dual peptide-polymer system to address composite-tooth interface vulnerability. The adhesive system incorporates an antimicrobial peptide to inhibit bacterial attack and a hydroxyapatite-binding peptide to promote remineralization of damaged tooth structure. A designer spacer sequence was incorporated into each peptide sequence to not only provide a conjugation site for methacrylate (MA) monomer but also to retain active peptide conformations and enhance the display of the peptides in the material. The resulting MA-antimicrobial peptides and MA-remineralization peptides were copolymerized into dental adhesives formulations. The results on the adhesive system composed of co-tethered peptides demonstrated both strong metabolic inhibition of S. mutans and localized calcium phosphate remineralization. Overall, the result offers a reconfigurable and tunable peptide-polymer hybrid system as next-generation adhesives to address composite-tooth interface vulnerability.

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Section: Resultsmentioning

confidence: 99%

Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives

Yuca

Xie

Song

et al. 2021

IJMS

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“…This is due to the inhibition role of fluoride to the diffusion of xylitol into subsurface enamel layers, therefor reducing its remineralization effect. This theory was however rejected by Cardoso et al, 2016 (26), who compared the effect of varnishes containing xylitol with commercial fluoridated varnishes on the remineralization of artificial enamel caries lesions in situ. Surface hardness and transversal microradiography were used.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fluoride Varnish Containing Xylitol-Coated Calcium and Phosphate on the Remineralization of Caries Like Lesions in Primary Teeth

Elhangour

Bakry

Soliman

et al. 2021

Alexandria Dental Journal

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INTRODUCTION:Embrace TM Varnish is a new fluoride varnish which contains xylitol-coated calcium and phosphate (XCP). This combination leads to increase the release time of fluoride in this varnish. OBJECTIVES: To compare the remineralizing effect of Embrace TM varnish with Profluoride ® varnish on caries-like lesions in primary teeth regarding lesion depth and calcium and phosphate enamel content. MATERIALS AND METHODS: Forty eight anterior primary teeth were coated with nail varnish, leaving squares of 4x4 mm then sectioned longitudinally in a labiolingual direction into two equal halves. Each half was considered as a specimen (96 specimens). Carieslike lesions were created in all specimens. Specimens were divided into two groups. group I (n=48) was subdivided into subgroup IA (n=24) treated with Embrace TM varnish and subgroup IB (n=24) served as control, while groupII (n=48) was subdivided into subgroup IIA (n=24) treated with Profluoride ® varnish and subgroup IIB (n=24) served as control. Specimens were subjected to pH cycling then they were examined with polarized light microscopy and energy dispersive X-ray spectrometer. RESULTS: No significant difference in mean percent reduction in lesion depth following treatment with Embrace TM varnish and Profluoride ® varnish (49.51 and 45.11, respectively) at P= 0.58. Greater significant of calcium phosphate ratio was found for Embrace TM varnish (2.25±0.43) than Profluoride ® varnish (1.65±0.05) at P< 0.0001. Significance was set at the 5% level. CONCLUSIONS: Embrace TM varnish had no significant difference in mean percent reduction in lesion depth than Profluoride ® varnish, while it had a better remineralization effect than Profluoride ® varnish in terms of higher mineral content. KEYWORDS: Embrace TM varnish, Xylitol coated Calcium and Phosphate (XCP), fluoride varnish, polarized light microscopy, energy dispersive x-ray spectrometer. __________________________________________________________________________________________________ 1 Dentist in the Egyptian Ministry of Health and Population.

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“…Ltd Baikampady, Mangalore, Karnataka. HV= 1.854 L / d 2 Where, L = Denotes the applied load on indenter in kg. d = for, mean diagonal of indentation, in mm.…”

Section: Methodology:-mentioning

confidence: 99%

“…The process of demineralization involves thedissolution of hydroxyapatite, which is primarily caused by acidic attacks resultingfrom microbial biofilm by fermentation of sugars, resulting in a demineralizedlesion. 2 demineralized lesions can progress from initial demineralization to non cavitated lesions, and finally to cavitated lesions. The initial clinical demineralizationstage is termed a white spot lesion, white spot lesions represent the first visualclinical stage of incipient caries.…”

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Comparative Evaluation of Remineralization Potential of Sodium Fluoride Varnish and Sodium Fluoride Varnish Fortified With Bioglass -an in Vitro Study

M.S¹,

Barkathunnisa²,

Anusha³

et al. 2022

IJAR

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Aim:- The present study is aimed to compare and evaluate the remineralization potential of Sodium fluoride varnish alone and sodium fluoride varnish fortified with bioglass Material And Method:- caries like lesions were produced and surface microhardness was evaluated. The specimens were then divided into 2 groups with 36 teeth in each group, accordingly remineralization treatment was employed. 36 teeth were treated with sodium fluoride varnish (duraphat) (group 1) and 36 teeth with treated with sodium fluoride fortified with bioglass (Fluro dip bioactive) (group 2). During the next 10 days, the samples were subjected to a pH-cycling system, which simulated the intraoral conditions, surface microhardnesstesting was performed on the 11th day to evaluate remineralization. The values obtained were tabulated and statistically analyzed using one-way ANOVA. Result:- Significant remineralization was seen with sodium fluoride fortified with bioglass followed by sodium fluoride varnish. Conclusion:- The results of the study concluded that sodium fluoride varnish fortified with bioglass has better remineralizing potential than Sodium fluoride varnish alone and can be used to reduce caries advancements at the stage of early carious lesions.

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In vitro remineralization of primary teeth with a mineralization-promoting peptide containing dental varnish

Cited by 13 publications

References 41 publications

Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives

Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives

Effect of Fluoride Varnish Containing Xylitol-Coated Calcium and Phosphate on the Remineralization of Caries Like Lesions in Primary Teeth

Comparative Evaluation of Remineralization Potential of Sodium Fluoride Varnish and Sodium Fluoride Varnish Fortified With Bioglass -an in Vitro Study

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