In vitro screening and isolation of human aromatase inhibitors from <i>Cicer arietinum</i> by a novel continuous online method combining chromatographic techniques

Zhang, Yuchi; Liu, Chengyu; Liu, Chunming; Li, Sainan

doi:10.1002/jssc.201700990

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…Furthermore, the extract obtained from the second segment had the highest caffeine and theobromine, two compounds of significant bioactivity. Zhang et al [ 190 ] developed HPLE merged with countercurrent chromatography (CCC) and preparative liquid chromatography (PLC) to extract and isolate Cicer arietinum seeds’ phenolics. The HPLE extraction was conducted using an aqueous ethanol solution with a volume-to- volume ratio of 60%.…”

Section: Integrations Of Avant-garde Extraction Technologiesmentioning

confidence: 99%

Recent advances in combined Avant-garde technologies (thermal-thermal, non-thermal-non-thermal, and thermal-non-thermal matrix) to extract polyphenols from agro byproducts

Boateng

2023

Journal of Food and Drug Analysis

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Because food byproducts (waste) are rich in phytoconstituents, valorizing them is crucial for global food security. However, conventional extraction (CE), including decoction, maceration, Soxhlet, etc., for agro byproducts’ polyphenol extraction are time-consuming and rely significantly on vast volumes of potentially aggressive solvents. Hence, Avantgarde extraction technologies, including non-thermal (high hydrostatic pressure (HHPE), pulsed-electric field (PEF), high voltage electrical discharges (HVED), etc.) and thermal extraction (supercritical fluid (SCF), subcritical water extraction (SWE), microwave-assisted extraction (MAE), etc.), as well as their thermal combinations (SCF-PLE, SCCO 2 -SWE, SCCO 2 -MAE, etc.), non-thermal combinations (HHPE + UAE, PEF + UAE, HVED + UAE, etc.) and combined thermalnon-thermal (MAE-UAE, etc.) are increasingly replacing CE. However, a review of combined Avant-garde extraction escalation technologies (non-thermal/thermal extraction matrix) for extracting polyphenols from agro-byproducts is limited. Hence, this manuscript reviewed Avant-garde extraction technologies (non-thermal/thermal extraction matrix) for extracting phenolics from agro-byproducts in the last 5 years. The key factors affecting polyphenols’ extraction from the byproduct, the recent applications of Avant-garde technologies, and their principle were reviewed using databases from Web of Science and Lens.org . The results demonstrated that combined Avant-garde extraction escalation technologies increase extractability, resulting in polyphenols with higher extraction rates, fewer contaminants, and preservation of thermosensitive components. Therefore, combined Avant-garde extraction technologies should be explored over the next five years. Implementing an integrated process and the strategic sequencing of diverse Avant-garde extraction technologies are important. Thus, further investigation is required to explore the sequencing process and its potential impact on the extraction of phenolics from agro-byproducts.

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Section: Integrations Of Avant-garde Extraction Technologiesmentioning

confidence: 99%

Recent advances in combined Avant-garde technologies (thermal-thermal, non-thermal-non-thermal, and thermal-non-thermal matrix) to extract polyphenols from agro byproducts

Boateng

2023

Journal of Food and Drug Analysis

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“…PLE was also used in online extraction and separation systems for the extraction of polyphenolic compounds. In this sense, Zhang et al [62] assembled a continuous online system comprising PLE coupled to countercurrent chromatography (CCC) and preparative liquid chromatography (PLC) for the extraction and isolation of bioactive compounds (human aromatase inhibitors) from Cicer arietinum seeds. The PLE extraction was performed using aqueous ethanol (60% v/v) at 80°C for 5 min.…”

Section: Pressurized Liquid Extraction 387mentioning

confidence: 99%

Pressurized Liquid Extraction

2022

Extraction Techniques for Environmental Analysis

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Pressurized liquid extraction employs the use of solvents at high temperatures, above its boiling point and below its critical point, under enough pressure to maintain them in a liquid state. In this section, the essential criteria for the selection of appropriate operational parameters will be provided from a theoretical point of view. Additionally, the fundamental principles of PLE for solid samples are described. Due to the limitations of commercial equipment, the only possibility to deal with liquid samples is by transforming them into solids, for example, by adding an ab/adsorbent.

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“…Hence, semi‐PLC and CCC can be combined to purify the target bioactive compounds with different polarities because of their complementary and orthogonal properties . The combined use of semi‐PLC and other separation techniques is also reported . For the automation of mixed chromatography and integrated separation and extraction of natural compounds, online hyphenated techniques including PLE, semi‐PLC, and CCC were established in this study for the extraction and online isolation of COX‐2 inhibitors from P. amurense Ruprecht.…”

Section: Introductionmentioning

confidence: 99%

Screening and isolation of cyclooxygenase‐2 inhibitors from the stem bark of Phellodendron amurense Ruprecht by ultrafiltration with liquid chromatography and tandem mass spectrometry, and complex chromatography

Zhang

Shi

et al. 2019

J of Separation Science

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Nonsteroidal anti‐inflammatory drugs appear to reduce the risk of developing cancer. One mechanism through which nonsteroidal anti‐inflammatory drugs act to prevent carcinogenesis is inhibition of the activity of the enzyme cyclooxygenase‐2. The cyclooxygenase‐2 inhibitors are widely used to reduce the risk of developing cancer. Natural products are considered to be a promising source of several novel cyclooxygenase‐2 inhibitors. Ultrafiltration with liquid chromatography and mass spectrometry is an efficient method that can be applied to rapidly screen and identify the ligands from the barks of Phellodendron amurense Ruprecht. A continuous online method comprised of pressurized liquid extraction, countercurrent chromatography, and semi‐preparative liquid chromatography was developed for the efficient scaled‐up production of eight compounds with high purities. The bioactivities of the separated compounds were assessed by an in vitro enzyme inhibition assay. The use of bioactivity screening method combined with preparation method of bioactive compounds and an in vitro enzyme inhibition assay facilitated the efficient screening and isolation of the cyclooxygenase‐2 inhibitors from complex samples. This could be used as an efficient method for the large‐scale production of functional ingredients.

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In vitro screening and isolation of human aromatase inhibitors from Cicer arietinum by a novel continuous online method combining chromatographic techniques

Cited by 10 publications

References 29 publications

Recent advances in combined Avant-garde technologies (thermal-thermal, non-thermal-non-thermal, and thermal-non-thermal matrix) to extract polyphenols from agro byproducts

Recent advances in combined Avant-garde technologies (thermal-thermal, non-thermal-non-thermal, and thermal-non-thermal matrix) to extract polyphenols from agro byproducts

Pressurized Liquid Extraction

Screening and isolation of cyclooxygenase‐2 inhibitors from the stem bark of Phellodendron amurense Ruprecht by ultrafiltration with liquid chromatography and tandem mass spectrometry, and complex chromatography

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