In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa

Adewusi, Emmanuel Adekanmi; Steenkamp, Vanessa

doi:10.1016/s1995-7645(11)60203-4

Cited by 110 publications

(72 citation statements)

References 48 publications

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“…[4][5][6][7][8][9] The degradation or removal of the free radicals may not be completely controlled by endogenous enzymes such as superoxide dismutase, glutathione, but herbal products rich in phenolic contents are reported to possess important roles in the prevention of oxidation deterioration and decreasing the levels of free radicals and for this reason, many traditional plants have been screened for their phenolic content and free radical scavenging activities. 10,11 Hydrogen peroxide, superoxide anion, hydroxyl and nitric oxide radical are free radicals, that producing during cellular oxidation naturally, are unstable and highly reactive molecules. 12 Hydrogen peroxide (H 2 O 2 ) in the presence of UV, a known reactive oxygen species (ROS) generating system, is capable of producing molecules containing unpaired electrons named as free radicals that can damage biomolecules including proteins, lipids, carbohydrates, enzymes, RNA and DNA.…”

Section: -3mentioning

confidence: 99%

Variation in Total Polyphenolic Contents, DNA Protective Potential and Antioxidant Capacity from Aqueous and Ethanol Extracts in Different Plant Parts of Hypericum perforatum L.

Şekeroğlu¹,

Urlu²,

Kulak³

et al. 2017

IJPER

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Background and Purpose: Hypericum perforatum belonging to the family Hypericaceae is a reputed medicinal plant including a wide ranges of important phytochemical components. Chlorogenic acid, rutin, hyperoside, quercitrin, quercetin, pseudohypericin, hypericin and hyperforin are of the major components. Crude extract and individual compounds of H. perforatum have been reported to exert antidepressant, antibiotic, and antitumoral activities. It is worthy to note that the quantity and efficacies of the crude extracts or individual compound are not constant, which are strongly influenced by different climatic conditions, harvesting times, harvested plant organs and post-harvest practices. Hence, numerous studies on H. perforatum collected from different parts of the World are carried out for their desired quality and biological efficacy. Methods: Wild collected plant materials were dried and preserved with a voucher specimen number and were extracted using maceration at room temperature for 24 h in dark. Subsequently, extracts were screened for their phenolic and flavonoid contents, plausible antioxidant activities using two methods namely DPPH radical scavenging and ferric-reducing antioxidant power (FRAP) assays and DNA protective activities. Results: The highlights of the study were are listed as 1) the highest total phenolic content in ethanol extracts of leaf, ii) the highest total flavonoid content in flower, iii) DPPH scavenging activity in leaf (80.51 %), flower (63.42 %) and stem (48.20 %), iv) highest ferric reduction capacity in ethanol extracts of stem were determined. Also, potent DNA protection activity was observed even at the lowest concentration value (25µg/ml) of the extracts. Conclusion: The phenolic content and strong antioxidant activities of ethanol extracts of different parts of the plant are reported. All the extracts exhibited strong DNA protective activities in response to the UV radiation in the presence of hydrogen peroxide.

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Section: -3mentioning

confidence: 99%

Variation in Total Polyphenolic Contents, DNA Protective Potential and Antioxidant Capacity from Aqueous and Ethanol Extracts in Different Plant Parts of Hypericum perforatum L.

Şekeroğlu¹,

Urlu²,

Kulak³

et al. 2017

IJPER

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“…Alkaloids are considered the major bioactive components of C. bulbispermum which exhibits various pharmacological effects [24,32,[36][37][38][39][40][41]. Six distinct and structurally diverse isoquinoline alkaloids characteristic of the Amaryllidaceae family [42] Table 3).…”

Section: Phytochemistrymentioning

confidence: 99%

“…Some of the listed pharmacological activities may not relate directly to the ethnomedicinal uses of C. bulbispermum, but may provide some insight into its potential therapeutic value and bioactive properties. A wide range of biological activities have been reported including antimicrobial [36], antinociceptive [37], antiplasmodial [38], antioxidant [37,39], cytotoxicity and anti-apoptotic [24,37,40,41] as well as effects on the central nervous system (CNS) [37].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

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Ethnobotanical, phytochemical and pharmacological properties of <i>Crinum bulbispermum</i> (Burm f) Milne-Redh and Schweick (Amaryllidaceae)

Maroyi¹

2016

Trop. J. Pharm Res

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“…This number may rapidly increase in the coming years considering the predicted increase in life expectancy in most countries [2]. The threat posed by AD is gradually increasing as compared to other fatal diseases like cancer, stroke and heart disease [3].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants Anti-cholinesterase Activity and the Potential for Alzheimer’s Disease Treatment

Usman¹

2017

JDMP

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Abstract:Alzheimer's disease (AD) is a slow and progressive neurodegenerative disease, leading to a breakdown in memory preservation and absence of cognitive reasoning and language skills. It is the most popular neurodegenerative disease worldwide, with nearly 20 million new incidences recorded every year. The enzymes, acetyl cholinesterase (AChE) and butyryl-cholinesterase (BChE) play important roles in the cholinergic deficit through enhanced degradation of the neurotransmitter, acetylcholine (ACh). In most cases, to improve neurotransmission and to alleviate cholinergic deficit, the focus is mainly on acetyl cholinesterase (AChE) and butyl cholinesterase (BCh). Currently, drugs for the treatment of AD (Rivastigmine, galanthamine, donepezil and Memantine) targets the later stages and implicated in the progression of the disease. Acetyl cholinesterase enzyme (AChE) is especially an attractive target for the rational drug design and for the discovery of mechanism based inhibitors; this is because of its role in the hydrolysis of neurotransmitter, acetylcholine. Many plants serve as potential source of AChE and BChE inhibitors, and useful compounds that could provide templates for the development of drugs for the treatment of AD. This paper provides a review of several medicinal plants tested for anti-AChE and or BChE, many of which contains promising bioactive compounds as potential anti-cholinesterase that could serve as candidates for the development of drugs to treat AD.

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In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa

Abstract: Five plants show good antioxidant and AChEI activity. These findings support the traditional use of the plants for treating neurological disorders especially where a cholinesterase mechanism and reactive oxygen species (ROS) are involved.

Cited by 110 publications

References 48 publications

Variation in Total Polyphenolic Contents, DNA Protective Potential and Antioxidant Capacity from Aqueous and Ethanol Extracts in Different Plant Parts of Hypericum perforatum L.

Variation in Total Polyphenolic Contents, DNA Protective Potential and Antioxidant Capacity from Aqueous and Ethanol Extracts in Different Plant Parts of Hypericum perforatum L.

Ethnobotanical, phytochemical and pharmacological properties of <i>Crinum bulbispermum</i> (Burm f) Milne-Redh and Schweick (Amaryllidaceae)

Medicinal Plants Anti-cholinesterase Activity and the Potential for Alzheimer’s Disease Treatment

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