In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts

손현정,; 엄민영,; 김인호,; 조승목,; 한대석,; 이창호,

doi:10.3746/jkfn.2016.45.7.966

Cited by 14 publications

(7 citation statements)

References 28 publications

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“…In our study, EEI dose‐dependently increased the percentage inhibition of AChE in the range 50–1,000 μg/ml, although the effects were lower than those of tacrine. However, compared to the results of Son et al () for the AChE inhibitory activity of 20 seaweed extracts, the EEI was more effective than 1 mg/ml Ecklonia cava , showing the highest AChE inhibitory activity (35.9 ± 0.5%).…”

Section: Discussioncontrasting

confidence: 60%

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Memory‐enhancing effects ofIshige foliaceaextract: In vitro and in vivo study

et al. 2020

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Ishige foliacea is used as a functional food in East‐Asian countries. We evaluated the memory‐enhancing effect of an ethanol extract of I. foliacea (EEI) using in vitro and in vivo models. In vitro acetylcholinesterase and β‐secretase inhibitory activities, antioxidant properties, and neuroprotective effects against human neuronal cell death by H2O2 and β‐amyloid (Aβ) were investigated. We explored the memory‐enhancing effect and its underlying mechanism in a mouse model of scopolamine (SCO)‐induced memory deficits. EEI showed free radical scavenging and acetylcholinesterase and β‐secretase inhibition activities. Additionally, EEI significantly decreased neuronal cell death induced by H2O2 or Aβ in human neuroblastoma SH‐SY5Y cells. In behavior tests, SCO‐induced memory deficits was improved by EEI administration. EEI increased the protein expression of brain‐derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) and phosphorylated extracellular signal‐regulated kinase, which are related to synaptic plasticity in the hippocampus. EEI may ameliorate memory deficits and prevent neurodegenerative disorders. Practical applications As the population ages, dementia, a neurodegenerative disease, is becoming an important problem. Various Alzheimer's drugs have been developed based on the disease mechanism, but alternative treatments are required because of the low bioavailability and hepatotoxicity of current medications. Ishige foliacea is a type of brown algae containing various bioactive substances. Phlorotannins, known as brown algae polyphenols, have been studied for their various functionalities such as, anticancer, anti‐obesity, antioxidant, and sleep improvement effects, and have attracted attention as raw materials for developing new natural products. We found that the EEI mitigates SCO‐induced damage by protecting neurons from oxidative stress‐induced cell damage, controlling synthesis mechanisms of the causative agents of AD, and activating BDNF–TrkB–ERK signaling to promote memory function in the hippocampus. The results of this study can serve as a foundation for further research. Additionally, I. foliacea may be useful for treating and improving AD.

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Section: Discussioncontrasting

confidence: 60%

“…Therefore, in this study, the inhibitory activity of the EEI at various concentrations against BACE1 which may affect Aβ accumulation was measured. The maximum inhibitory effect of 77.79% was observed at 1,000 μg/ml, which is higher than those of the 20 seaweed extracts reported by Son et al (2016).…”

Section: Melamedcontrasting

confidence: 59%

Memory‐enhancing effects ofIshige foliaceaextract: In vitro and in vivo study

et al. 2020

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“…Therefore, mitochondrial dysfunction inhibits ACh synthesis and decreases neurotransmission, and the AChE inhibitor as a classical pharmacological target of AD therapy is thought to be beneficial by improving the neuronal transmission of ACh. As a result of measuring the AChE-inhibitory activity of 20 kinds of seaweed, E. cava (35.85% at 1 mg/ml), Ecklonia kurome, and Myelophycus simplex extracts were reported as the most effective [35]. Compared with these results, FEC seems to have a similar inhibitory effect to E. cava extract of that study, but is slightly lower than tacrine as a positive control.…”

Section: Discussionmentioning

confidence: 54%

Protective Effect of Fucoidan Extract from Ecklonia cava on Hydrogen Peroxide-Induced Neurotoxicity

Park

Kang

Kim

et al. 2018

Journal of Microbiology and Biotechnology

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We evaluated the antioxidant activity and neuronal cell-protective effect of fucoidan extract from Ecklonia cava (FEC) on hydrogen peroxide (H 2 O 2 5 0 value = 1.3 mg/ml) and showed a mixed (competitive and noncompetitive) pattern of inhibition. Our findings suggest that FEC may be used as a potential material for alleviating oxidative stress-induced neuronal damage by regulating mitochondrial function and AChE inhibition.

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“…EC and EK together inhibited AChE and BACE1 by 84.41 ± 1.70 and 81.17 ± 2.43%, respectively, reducing neuronal cell death and improving dementia, highlighting their synergistic potential. EK likewise showed the highest result of the 2,2 0 -azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay (IC 50 = 0.07 ± 0.01 mg/mL), which the researchers attributed to its TPC (Son et al 2016). Kim et al (2014e) further highlighted the importance of EC for its potential analgesic effects in postoperative pain and neuropathic pain.…”

Section: Neuroprotective Activitymentioning

confidence: 94%

Recent advances in pharmacological research on Ecklonia species: a review

2017

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The genus Ecklonia (Lessoniaceae, Phaeophyceae), commonly called kelp (brown algae), is abundant on the coasts of Japan and Korea. During the past few decades, Ecklonia species have received tremendous attention for their wide range of therapeutic properties and multiple health benefits, such as great nutritional value and being rich in vitamins, minerals, dietary fiber, proteins, and polysaccharides. Several novel functional ingredients with diversified biological activities have been isolated and possess antimicrobial, antiviral, hepatoprotective, cardioprotective, anti-inflammatory, neuroprotective, anticarcinogenic, immunomodulatory, hypolipidemic, anti-diabetic, and antioxidant therapeutic properties. The present review discusses the phytochemical, pharmacological, therapeutic, nutritional, and health benefits of different species of genus Ecklonia, as well as their use in the prevention of disease and maintenance of good health.

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In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts

Cited by 14 publications

References 28 publications

Memory‐enhancing effects ofIshige foliaceaextract: In vitro and in vivo study

Memory‐enhancing effects ofIshige foliaceaextract: In vitro and in vivo study

Protective Effect of Fucoidan Extract from Ecklonia cava on Hydrogen Peroxide-Induced Neurotoxicity

Recent advances in pharmacological research on Ecklonia species: a review

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