In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE)

Hansen, Klaus; Nyman, Ulf; Smitt, Ulla Wagner; Adsersen, Anne; Gudiksen, Lene; Sreedharan, Rajasekharan; Pushpangadan, P.

doi:10.1016/0378-8741(95)01286-m

Cited by 83 publications

(53 citation statements)

References 13 publications

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“…Chinese herbs such as Tianma ( Gastrodia ) [126] and Gouteng ( Uncaria ) [127] could suppress liver yang hyperactivity. Niuxi ( Achyranthes root) [128] and Duzhong ( Eucommia ulmoides ) [129–131] had antihypertensive effects by nourishing the kidney. Third, when aiming to cure phlegm-damp retention, use Wuling powder [132], Zexie Tang (decoction of Alisma ) [133], and Wendantang jiawei decoction (modified decoction for clearing away gallbladder heat).…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Wang

Xiong

Liu

2014

Evidence-Based Complementary and Alternative Medicine

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Background. To simplify traditional Chinese medicine syndrome differentiation and allow researchers to master syndrome differentiation for hypertension, this paper retrospectively studied the literature and analyzed syndrome elements corresponding to hypertension syndromes. Methods. Six databases including PubMed, EMBASE, Chinese Bio-Medical Literature Database, Chinese National Knowledge Infrastructure, Chinese Scientific Journal Database, and Wan-fang Data were searched from 1/January/2003 to 30/October/2013. We included all clinical literature testing hypertension syndromes and retrospectively studied the hypertension literature published from 2003 to 2013. Descriptive statistics calculated frequencies and percentages. Results. 13,272 patients with essential hypertension were included. Clinical features of hypertension could be attributed to 11 kinds of syndrome factors. Among them, seven syndrome factors were excess, while four syndrome factors were deficient. Syndrome targets were mainly in the liver and related to the kidney and spleen. There were 33 combination syndromes. Frequency of single-factor syndromes was 31.77% and frequency of two-factor syndromes was 62.26%. Conclusions. Excess syndrome factors of hypertension patients include yang hyperactivity, blood stasis, phlegm turbidity, internal dampness, and internal fire. Deficient syndrome factors of hypertension patients are yin deficiency and yang deficiency. Yin deficiency with yang hyperactivity, phlegm-dampness retention, and deficiency of both yin and yang were the three most common syndromes in clinical combination.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Wang

Xiong

Liu

2014

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…It was reported that B. diffusa have ACE inhibitory activity (Hansen et al, 1995). ROS also culminate in phospholipase A 2 activation through transcription factor NF-κB (Lappas et al, 2004), as NF-κB can be activated by the stress of oxidants (Siebenlist et al, 1994) and oxalate exposure promotes rapid degradation of IκBα, an endogenous inhibitor of the NF-κB transcription factor (Jonassen et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

Pareta

Patra

Mazumder

et al. 2011

Pharmaceutical Biology

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“…The in vitro ACE inhibitory activity was measured using the method described by Elbl and Wagner (1991), which was later modified by Hansen et al (1995). Briefly, the chromophore-fluorophore labelled substrate dansyltriglycine was cleaved by an angiotensin I-converting enzyme preparation from rabbit lung (EC 3.4.15.1) into dansylglycine, which is quantitatively measured by HPLC.…”

Section: Luteolin (2)mentioning

confidence: 99%

Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)

Loizzo

Said

Tundis

et al. 2006

Phytotherapy Research

172

115

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In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE)

Cited by 83 publications

References 13 publications

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Traditional Chinese Medicine Syndromes for Essential Hypertension: A Literature Analysis of 13,272 Patients

Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)

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