In vitro selenium bioaccessibility combined with in vivo bioavailability and bioactivity in Se-enriched microalga (Chlorella sorokiniana) to be used as functional food

Gómez-Jacinto, Veronica; Navarro-Roldán, Francisco; Garbayo-Nores, Inés; Vílchez, Carlos; Arias-Borrego, Ana; García-Barrera, Tamara

doi:10.1016/j.jff.2020.103817

Cited by 31 publications

(34 citation statements)

References 39 publications

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“… 5 The most commonly marketed Se-enriched product is yeast Saccharomyces cerevisiae , but other functional foods have also been proposed such as Chlorella sorokiniana . 5 Moreover, minerals such as Se can shape the colonization of gut microbiota, deeply affecting the host health. 6 Accumulating data are demonstrating the pivotal role of gut microbiota on human health.…”

Section: Introductionmentioning

confidence: 99%

“…The main source of Se is the diet, but the relationship between the status and dietary intake of this micronutrient is close to a U-shape, where adverse effects are derived from deficiency and excess, the Se-essentiality being conditioned to a narrow range of concentrations . This means that Se-enriched nutraceuticals and functional foods should control the bioavailable concentration of this element; however, the chemical form of Se used is also of importance . The most commonly marketed Se-enriched product is yeast Saccharomyces cerevisiae, but other functional foods have also been proposed such as Chlorella sorokiniana .…”

Section: Introductionmentioning

confidence: 99%

“…This means that Se-enriched nutraceuticals and functional foods should control the bioavailable concentration of this element; however, the chemical form of Se used is also of importance . The most commonly marketed Se-enriched product is yeast Saccharomyces cerevisiae, but other functional foods have also been proposed such as Chlorella sorokiniana . Moreover, minerals such as Se can shape the colonization of gut microbiota, deeply affecting the host health .…”

Section: Introductionmentioning

confidence: 99%

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Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model

Callejón‐Leblic

Selma‐Royo

Collado

et al. 2021

J. Agric. Food Chem.

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Selenium (Se) is a micronutrient involved in important health functions and it has been suggested to shape gut microbiota. Limited information on Se assimilation by gut microbes and the possible link with selenoproteins are available. For this purpose, conventional and gut microbiota-depleted BALB/c mice were fed a Se-supplemented diet. The absolute quantification of mice plasma selenoproteins was performed for the first time using heteroatom-tagged proteomics. The gut microbiota profile was analyzed by 16S rRNA gene sequencing. Se-supplementation modulated the concentration of the antioxidant glutathione peroxidase and the Se-transporter selenoalbumin as well as the metal homeostasis, being influenced by microbiota disruption, which suggests an intertwined mechanism. Se also modulated microbiota diversity and richness and increased the relative abundance of some health-relevant taxa ( e.g. , families Christensenellaceae , Ruminococcaceae , and Lactobacillus genus). This study demonstrated the potential beneficial effects of Se on gut microbiota, especially after antibiotic-treatment and the first associations between specific bacteria and plasma selenoproteins.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model

Callejón‐Leblic

Selma‐Royo

Collado

et al. 2021

J. Agric. Food Chem.

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“…9 Many plants are able to accomplish Se enrichment via their bioactive organic compounds, which is significant to supplement Se. 10 The strategy usually in Se-deficient regions is amending soils with inorganic Se-containing fertilizers during cultivation of biofortified products, while Se-enriched food supplements can be obtained directly in the seleniferous region by naturally agronomic cultivars. The increasing demand of daily dietary Se intake as the low-cost agricultural strategy for biofortification is needed, which can be realized using the seleniferous region to breed ordinary cultivars.…”

Section: ■ Introductionmentioning

confidence: 99%

Investigation of Differentially Expressed Proteins Induced by Alteration of Natural Se Uptake with Ultrahigh-Performance Liquid Chromatography Quadrupole Orbitrap Uncovers the Potential Nutritional Value in Se-Enriched Green Tea

Jia

Liu

Shi

et al. 2020

J. Agric. Food Chem.

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Se-enriched green tea, with an increasing consumption, is the shoot of tea plants grown naturally in a seleniferous region. A label-free proteomic strategy based on ultrahigh-performance liquid chromatography quadrupole Orbitrap was applied to characterize and distinguish the difference between the Se-enriched and normal green tea with a total of 283 proteins identified and 264 proteins quantified, in which 96 proteins were observed different. The expressions of 10 proteins were upregulated and 40 proteins were downregulated (p < 0.05) in Se-enriched samples. Gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway, and protein–protein interaction (PPI) network analysis results indicated that these differentially expressed proteins significantly interacted and were involved in secondary metabolites and inflammatory response biological processes. Furthermore, the expression of methyl-jasmonate- and ethylene-related genes changed significantly in Se-enriched green tea, and catalase proteins were employed as the center of the pathway that changed significantly in the PPI network. These results associating with the current knowledge of selenium in soil–plant cycling revealed that organic selenium was synthesized in green tea, which provided novel information on Se assimilation in Camellia sinensis and improved the understanding of Se-enriched green tea as a possible ideal selenium supplement in daily life.

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“… 2 Se and selenoproteins have chemopreventive properties against cancer 3 and reduce the incidence and severity of various viral infections including COVID-19. 4 Due to their relationship with health, functional foods and nutraceuticals enriched with Se 5 , 6 have been extensively described. Moreover, the effect of Se on the intestinal microbiota, by shaping the microbial composition and diversity, and also by improving intestinal mucositis, has also been suggested.…”

Section: Introductionmentioning

confidence: 99%

Untargeted Gut Metabolomics to Delve the Interplay between Selenium Supplementation and Gut Microbiota

et al. 2021

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Selenium (Se) is an essential trace element with important health roles due to the antioxidant properties of selenoproteins. To analyze the interplay between Se and gut microbiota, gut metabolomic profiles were determined in conventional (C) and microbiota depleted mice (Abx) after Se-supplementation (Abx-Se) by untargeted metabolomics, using an analytical multiplatform based on GC-MS and UHPLC-QTOF-MS (MassIVE ID MSV000087829). Gut microbiota profiling was performed by 16S rRNA gene amplicon sequencing. Significant differences in the levels of about 70% of the gut metabolites determined, including fatty acyls, glycerolipids, glycerophospholipids, and steroids, were found in Abx-Se compared to Abx, and only 30% were different between Abx-Se and C, suggesting an important effect of Se-supplementation on Abx mice metabolism. At genus level, the correlation analysis showed strong associations between metabolites and gut bacterial profiles. Likewise, higher abundance of Lactobacillus spp. , a potentially beneficial genus enriched after Se-supplementation, was associated with higher levels of prenol lipids, phosphatidylglycerols (C-Se), steroids and diterpenoids (Abx-Se), and also with lower levels of fatty acids (Abx-Se). Thus, we observed a crucial interaction between Se intake–microbiota–metabolites, although further studies to clarify the specific mechanisms are needed. This is the first study about untargeted gut metabolomics after microbiota depletion and Se-supplementation.

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In vitro selenium bioaccessibility combined with in vivo bioavailability and bioactivity in Se-enriched microalga (Chlorella sorokiniana) to be used as functional food

Cited by 31 publications

References 39 publications

Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model

Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model

Investigation of Differentially Expressed Proteins Induced by Alteration of Natural Se Uptake with Ultrahigh-Performance Liquid Chromatography Quadrupole Orbitrap Uncovers the Potential Nutritional Value in Se-Enriched Green Tea

Untargeted Gut Metabolomics to Delve the Interplay between Selenium Supplementation and Gut Microbiota

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