In vitro simulation of in vivo degradation and cyclic loading of novel degradable electrospun meshes for prolapse repair

Rynkevic, Rita; Martins, Pedro S.; Fernandes, A. A.; Vange, Jakob; Gallego, Monica Ramos; Wach, Radosław A.; Mes, Tristan; Bosman, Anton W.; Deprest, Jan

doi:10.1016/j.polymertesting.2019.105957

Cited by 12 publications

(13 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These alterations included a decreased stress at break and strain at break at low doses and a decreased Young’s modulus, strain and tensile strength at high doses . Conversely, a study by Rynkevic et al found that e-beam sterilization had no significant effect on ureido-pyrimidinone-PCL meshes, although e-beam radiation has been found to cause cross-linking, chain scission, and increased elasticity modulus in polycaprolactones. , …”

Section: Biomedical Applicationsmentioning

confidence: 99%

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

et al. 2021

View full text Add to dashboard Cite

Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors and strategies for designing and creating bioactive scaffolds. However, these defect-specific scaffolds, especially when utilizing degradable polymers as the base material, present processing challenges that are distinct and unique from other classes of materials. The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.

show abstract

Section: Biomedical Applicationsmentioning

confidence: 99%

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The 3D-printed PCL meshes exhibited superior strengths to those of commercial PP membranes. Furthermore, the meshes survived through 10,000 cyclic loadings [ 30 ] and showed the least residual strains. These properties provide advantages in terms of their long-term use for POP repair.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Drug-Eluting Polycaprolactone/poly(lactic-co-glycolic Acid) Prolapse Mats Using Solution-Extrusion 3D Printing and Coaxial Electrospinning Techniques

Chen

Lin

et al. 2021

Polymers

View full text Add to dashboard Cite

We developed biodegradable drug-eluting prolapse mats using solution-extrusion 3D printing and coaxial electrospinning techniques. The mats were composed of polycaprolactone (PCL) mesh and lidocaine-, estradiol-, metronidazole-, and connective tissue growth factor (CTGF)-incorporated poly(lactic-co-glycolic acid) (PLGA) nanofibers that mimic the structure of the natural extracellular matrix of most connective tissues. The mechanical properties of degradable prolapse membrane were assessed and compared to commercial non-degradable polypropylene knitted meshes clinically used for pelvic organ prolapse (POP) repair. The release behaviors of the drug-loaded hybrid degradable membranes were also characterized. The experimental results suggest that 3D-printed PCL meshes exhibited comparable strengths to commercial POP meshes and survived through 10,000 cycles of fatigue test without breakage. Hybrid PCL meshes/PLGA nanofibrous membranes provided a sustainable release of metronidazole, lidocaine, and estradiol for 4, 25, and 30 days, respectively, in vitro. The membranes further liberated high levels of CTGF for more than 30 days. The animal tests show that the mechanical property of PCL mesh decreased with time, mainly due to degradation of the polymers post-implantation. No adverse effect of the mesh/nanofibers was noted in the histological images. By adopting solution-extrusion 3D printing and coaxial electrospinning, degradable drug-eluting membranes can be fabricated for POP applications.

show abstract

“…also affects their properties. 80 Some techniques used in the production of porous polymers like scaffolds include polymerization using solvents, [81][82][83][84][85] the porogen technique, [86][87][88] electrospinning, [89][90][91][92] and 3D printing, [93][94][95][96][97] among others. Table 2 provides several examples of the wide range of pore sizes, weights, and morphology available in the market for the same and different types of meshes.…”

Section: Meshes For Hernia Repairmentioning

confidence: 99%

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods

Serrano‐Aroca

Pous‐Serrano

2021

J Biomedical Materials Res

View full text Add to dashboard Cite

Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

show abstract

In vitro simulation of in vivo degradation and cyclic loading of novel degradable electrospun meshes for prolapse repair

Cited by 12 publications

References 33 publications

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Fabrication of Drug-Eluting Polycaprolactone/poly(lactic-co-glycolic Acid) Prolapse Mats Using Solution-Extrusion 3D Printing and Coaxial Electrospinning Techniques

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods

Contact Info

Product

Resources

About