In vitro studies data on anticancer activity of Caesalpinia sappan L. heartwood and leaf extracts on MCF7 and A549 cell lines

Bukke, Arunkumar Naik; Hadi, Fathima Nazneen; Babu, K. Suresh; Shankar, Preethi

doi:10.1016/j.dib.2018.05.050

Cited by 34 publications

(15 citation statements)

References 4 publications

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“…Evidence has shown that brazilin exhibits multiple functions such as anti-inflammation activity, anti-platelet activity, anti-oxidative activities, preventing hepatotoxicity, and inducing immunological tolerance. 20,[46][47][48][49] It was reported that brazilin can be distributed in brain after intravenous administration of 50 mg/kg brazilin to rats, 50) which indicates that brazilin may act directly in brain by passing through the blood brain barrier. Since oxidative stress plays a crucial part in MDD, so we assumed that brazilin may have an antidepression effect by acting as an anti-oxidative factor.…”

Section: Discussionmentioning

confidence: 99%

“…1A), is well known for the natural red color dye for staining and has anti-oxidative stress, anti-inflammatory, anti-platelet concentration, and anti-cancer effects. [18][19][20][21] Considering the relationship of inflammation, oxidative stress and depression, in the present study, we evaluated the potential neuroprotective effects of brazilin on H 2 O 2 -induced rat pheochromocytoma (PC12) cell injury and chronic mild stress (CMS) mice model.…”

Section: Introductionmentioning

confidence: 99%

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Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice

Wang

Xiu

et al. 2019

Biological & Pharmaceutical Bulletin

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Increasing evidence shows depression relevant to oxidative stress and inflammation. Anti-inflammatory strategies or antioxidants have led to the development of new antidepressants. Brazilin is a natural product from the Chinese traditional medicine Caesalpinia sappan L., exerting anti-inflammatory, antioxidant, anti-platelet concentration, and anti-cancer effects. While the antidepressant effect of brazilin is largely unknown. In present study, we investigated the effects of brazilin on H 2 O 2-induced oxidative injury in PC12 cells and on depression-and anxiety-like behaviors of chronically mild stressed (CMS)-induced depression mice. It was found that brazilin pre-treatment (both 10 and 20 µM) significantly increased cell viability and decreased cell apoptosis in H 2 O 2-treated PC12 cells. Furthermore, repetitive administration of brazilin to CMS-induced depression mice by intraperitoneal injection (10 mg/kg) made the mice significantly lose their latency of feeding in novelty-suppressed feeding test (NSF), have more the sucrose preference in sucrose preference test (SPT), and more time spent in the central zone without affecting their crossing activity in open field test (OFT). These results suggested that brazilin can play a role in antidepressant and anxiolytic-like behaviors for CMS-induced depression mice probably through inhibiting the oxidative stress. Therefore, brazilin is worth to be further explored for treating depressive and anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice

Wang

Xiu

et al. 2019

Biological & Pharmaceutical Bulletin

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“…Significant cytotoxic property was observed for both crude extracts and bioactive compound. Further molecular docking proved the effectiveness of Brazilin A in the reduction of Bcl-2 apoptotic inhibitor [54]. Saraca asoca (Caesalpiniaceae family) was reported cytotoxic against AGS cell lines (IC50 value: 20 μg/mL).…”

Section: Caesalpiniaceaementioning

confidence: 95%

A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds

Mazumder

Biswas²,

Raja³

et al. 2020

Molecules

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Cancer or uncontrolled cell proliferation is a major health issue worldwide and is the second leading cause of deaths globally. The high mortality rate and toxicity associated with cancer chemotherapy or radiation therapy have encouraged the investigation of complementary and alternative treatment methods, such as plant-based drugs. Moreover, over 60% of the anti-cancer drugs are molecules derived from plants or their synthetic derivatives. Therefore, in the present review, an attempt has been made to summarize the cytotoxic plants available in the Indian subcontinent along with a description of their bio-active components. The review covers 99 plants of 57 families as well as over 110 isolated bioactive cytotoxic compounds, amongst which at least 20 are new compounds. Among the reported phytoconstituents, artemisinin, lupeol, curcumin, and quercetin are under clinical trials, while brazilin, catechin, ursolic acid, β-sitosterol, and myricetin are under pharmacokinetic development. However, for the remaining compounds, there is little or no information available. Therefore, further investigations are warranted on these subcontinent medicinal plants as an important source of novel cytotoxic agents.

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“…Dried heartwood of sappan has long been used as herbal medicines as it contains many phytochemicals and bioactive compounds 1 – 5 . The biological abilities of the wood extract in terms of antiacne 6 , anti-bacterial 7 , 8 , anticancer 9 , antidiabetic 10 , antidiarrhea 11 , antiinflammatory 12 – 14 , antioxidant 15 and anti-photoaging 16 activities have been demonstrated by a number of researchers.…”

Section: Introductionmentioning

confidence: 99%

Color and molecular structure alterations of brazilein extracted from Caesalpinia sappan L. under different pH and heating conditions

Ngamwonglumlert

Devahastin

Chiewchan

et al. 2020

Sci Rep

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Brazilein extract from sappan wood (Caesalpinia sappan L.) has potential for use as natural food colorant since it has no unique flavor and taste. Although brazilein has long been applied in several traditional foods and beverages, information on its stability, which is of importance for practical application, is still limited. In this work, brazilein was isolated from sappan wood; its purity was confirmed by nuclear magnetic resonance spectroscopy. Relations between molecular structures and color as well as thermal stabilities of brazilein in aqueous solutions at pH 3, 7 and 9 were for the first time investigated. At the lowest pH, zero net-charge structure of brazilein, which exhibited yellow color, was predominantly found. The deprotonated and fully deprotonated structures of brazilein, which exhibited orange and red colors, respectively, were found when pH of the aqueous solutions increased. The forms of brazilein existing at the higher pH suffered extensive degradation upon heating, while the form existing at the lowest pH possessed higher stability. Heat-induced deprotonation and degradation were confirmed by UV-visible and Fourier-transform infrared spectra as well as losses of brazilein content. Sappan (Caesalpinia sappan L.), which has several such local names as Buckham wood in English, Bois de sappan in French, Pau de sappan in Polish, Sappanholz in German, Su mu in Chinese, Suo in Japanese and Fang in Thai, is a wood in the family Leguminosae. This wood is naturally available throughout Asia, including China, Japan and Thailand. Due to its several valuable functions, this wood plant is also nowadays cultivated in various other regions of the world, including Africa, Europe as well as North and South Americas. Dried heartwood of sappan has long been used as herbal medicines as it contains many phytochemicals and bioactive compounds 1-5. The biological abilities of the wood extract in terms of antiacne 6 , anti-bacterial 7,8 , anticancer 9 , antidiabetic 10 , antidiarrhea 11 , antiinflammatory 12-14 , antioxidant 15 and anti-photoaging 16 activities have been demonstrated by a number of researchers. The major active ingredient of sappan is brazilin, which is a colorless phenolic compound consisting of two aromatic rings, one pyrone and one five-membered ring. Based on its molecular structure, brazilin is identified as a neoflavonoid. However, hydroxyl group in the brazilin structure is easily oxidized and can change into carbonyl group, resulting in the structural transformation and formation of brazilein, which is a colored compound 17-19. Brazilein has indeed widely been used as a natural colorant; sappan extract containing brazilein has traditionally been used in the painting of books as well as in the dyeing of silk and wool. Since an aqueous extract of sappan possesses many beneficial properties over other red-color pigments, e.g.

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In vitro studies data on anticancer activity of Caesalpinia sappan L. heartwood and leaf extracts on MCF7 and A549 cell lines

Cited by 34 publications

References 4 publications

Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice

Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice

A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds

Color and molecular structure alterations of brazilein extracted from Caesalpinia sappan L. under different pH and heating conditions

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