In vitro studies of a degradable device for controlled‐release of meloxicam

Çetin, Emel Öykü; Buduneli, Nurcan; Atlihan, Evren; Kirilmaz, Levent

doi:10.1111/j.1600-051x.2005.00755.x

Cited by 26 publications

(19 citation statements)

References 19 publications

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“…According to their relative inhibition of COX isoenzymes, NSAIDs can be classified as non-selective, COX-2 preferential or COX-2 selective 10,26 . Meloxicam is a NSAID of the acidic enolic class that preferentially inhibits the inducible COX-2 and shows a weaker influence on constitutive COX-1 10,16,17 ; it is thus largely used for treatment of acute and chronic painful, inflammatory and degenerative disorders 16,25,32 .…”

mentioning

confidence: 99%

“…Meloxicam is a NSAID of the acidic enolic class that preferentially inhibits the inducible COX-2 and shows a weaker influence on constitutive COX-1 10,16,17 ; it is thus largely used for treatment of acute and chronic painful, inflammatory and degenerative disorders 16,25,32 . In dentistry, there are few studies concerning the use of meloxicam 1,4,6,9,10,25 , and none of them assessed pain control in dental surgeries with postoperative administration of this agent.…”

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confidence: 99%

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Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

Calvo

Sakai

Giglio

et al. 2007

International Journal of Oral and Maxillofacial Surgery

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confidence: 99%

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confidence: 99%

Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

Calvo

Sakai

Giglio

et al. 2007

International Journal of Oral and Maxillofacial Surgery

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“…This difference in release rate is due to the decrease in the permeability coefficient of the cross-linked membrane resulting from the cross-link points (23). A similar decrease in meloxicam release from cross-linked gelatin inserts has been reported recently (24). Table II shows the treatment of release data according to the Higuchi equation.…”

Section: Methodsmentioning

confidence: 91%

Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release

Barat¹,

Srinatha²,

Pandit³

et al. 2007

Acta Pharmaceutica

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Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking onin vitrometronidazole releaseChitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading andin vitrometronidazole release kinetics. The fabricated inserts exhibited satisfactory physical characteristics. The mass of inserts was in the range of 5.63 ± 0.42 to 6.04 ± 0.89 mg. The thickness ranged from 0.46 ± 0.06 to 0.49 ± 0.08 mm. Metronidazole loading was in the range of 0.98 ± 0.09 to 1.07 ± 0.07 mg except for batch CM3 with MZ loading of 2.01 ± 0.08 mg. The inserts exhibited an initial burst release at the end of 24 h, irrespective of the drug to polymer ratio, plasticizer content or cross-linking. However, further drug release was sustained over the next 6 days. Cross-linking with 10% (m/m) of glutaraldehyde inhibited the burst release by ~30% and increased the mean dissolution time (MDT) from 0.67 to 8.59 days. The decrease in drug release was a result of reduced permeability of chitosan due to cross-linking.

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“…Gelatins from porcine skin (type A) were purchased from Sigma Co. Gelatin materials were prepared in the form of the films with thickness of about 0.1 mm; such thin films were used, for example, in dentistry as a biodegradable device for controlled release of antioxidant meloxicam into periodontal pocket [10]. To produce the films, 2 mL of film-forming gelatin solution (FFGS) was poured on a polymer substrate as a thin layer and dried at room temperature for several days.…”

Section: Experimental Preparation Of Gelatin Filmsmentioning

confidence: 99%

Thermogravimetric study of water affinity of gelatin materials

Kuzema

Stavinskaya

Лагута

et al. 2015

J Therm Anal Calorim

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Gelatin materials in the form of thin films were prepared using film-forming gelatin solutions with pH value of 2.5-6.8; interaction of gelatin with water in the films and in the solutions was studied. Thermogravimetric analysis at temperature up to 200°C was used to identify and characterize free and bound water present in dried films. To simulate the water-gelatin interaction and to interpret thermogravimetric data, quantum chemical calculations along with the studies on the films swelling were performed. For both free water and bound water, the parameters of thermal desorption process were found to be affected by pH of film-forming solution. The observed changes in content of free and bound water and in apparent activation energies of water thermal desorption may be attributed to the growth of the quantity of negatively charged groups in gelatin molecules upon pH increase and to the changes in film structure and water affinity resulting from the charged groups interaction. Thus, by varying pH of the solution, one may influence the affinity of the films with respect to water and change the properties and usability of gelatin materials.

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In vitro studies of a degradable device for controlled‐release of meloxicam

Cited by 26 publications

References 19 publications

Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release

Thermogravimetric study of water affinity of gelatin materials

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