In vitro studies of graphene oxide reinforced hydroxyapatite nanobiocomposite on human erythrocytes

Radha, G.; Vinod, K.; Venkatesan, Balaji; Vellaichamy, Elangovan; Balakumar, S.

doi:10.1063/1.4980360

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…However, they have an uncontrollable regeneration rate, making them difficult to be used and difficult to handle and process. Polymers of synthetic origin such as polycaprolactone (PCL) [215][216][217][218], poly(lactic acid) (PLA) [219][220][221], and poly(methyl methacrylate) (PMMA) [222] do not reproduce characteristics and behavior of the extracellular matrix, but they have good mechanical properties, besides being easily mass manufactured, which allows them to be adapted for specific applications.…”

Section: Hydroxyapatite Compoundsmentioning

confidence: 99%

“…Researchers observed that there was cell viability, besides good biocompatibility. Dalby et al [225] prepared a HAp/poly(methyl methacrylate) (PMMA) and found its potential to act as substrate for cells resembling human osteoblasts, just like Radha et al [222], which prepared HAp/PMMA scaffolds by means of thermally induced phase separation (TIPS) and wetchemical approach, proving their in vitro bioactivity and reasonable hemocompatibility. Chaudhuri et al [226] synthesized composite films of PVA/PVP/HAp, varying the concentration of HAp.…”

Section: Hydroxyapatite Compoundsmentioning

confidence: 99%

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A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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Section: Hydroxyapatite Compoundsmentioning

confidence: 99%

Section: Hydroxyapatite Compoundsmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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“…Regarding to works by Radha et al 2017, facilitates the stable interfacial nanocomposites between GO-HA and promotes cell proliferation. GO-HA nanocomposite was prepared through probe sonication process by functionalizing the HA onto the GO surface which would increases the mechanical, biostability and compatibility of GO-HA nanocomposite [83]. The amount of spherical HA in composites was decreased as increase weight percentage of GO, and the folds on GO surface were multiplied.…”

Section: Composite Interactionmentioning

confidence: 99%

Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

Hashim¹,

Frankel²,

Nordin³

2019

Ceramics - Silikaty

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Bacterial infection and cytotoxicity associated with implant materials used in medical devices are the major cause of implant failures. This review focusses upon the development of graphene oxide (GO)-hydroxyapatite (HA) nanocomposites as potential coating materials that can provide a solution to the rejection of implants. These nanocomposites combine the unique antibacterial properties of graphene oxide with the natural mineral composition of hydroxyapatite, as found in human bones and tooth enamel. They have potential antibacterial applications in the fields of orthopaedics, orthodontics and cardiovascular medicine. The methods used for preparation of HA and GO in addition to the combining of GO-HA nanocomposite are discussed. Cytotoxicity and antibacterial affects of GO and GO-HA to biological systems are examined as well as future applications in related fields.

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“…Thermally Induced Phase Separation (TIPS) method gained scientic interest as it has been shown to improve the dispersion of hydrophilic nanollers in the hydrophobic matrix, which could enhance the material's nal properties and the ease of its processing. 31,32 The preparation of PLA/HAp 33 and HAp/poly(methyl methacrylate) (PMMA) 34 composites via TIPS method was shown to result in a hybrid system with a potential application in the biomedical eld. Within this study, PLA/HAp biocomposite pellets were prepared by the (TIPS) method.…”

Section: Introductionmentioning

confidence: 99%