In Vitro Studies on Antioxidant, Hypolipidemic and Cytotoxic Potential of Parmelia Perlata

Rahman, Hafizur; Vijaya, B.; Ghosh, Sayani; Pant, Geetika; Sibi, G

doi:10.11648/j.ajls.s.2014020601.12

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…Methonolic extract of P. perlata showed significant antioxidant activity when tested in DPPH (2,2'-diphenyl-2-picrylhydrazyl) and phosphomolybdenum reduction assay 35 . The ethanolic extract also showed significantly good free radical scavenging effects and antioxidant potential 32 .…”

Section: Antioxidant Potentialmentioning

confidence: 99%

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Pharmacological and Phytochemical Aspects of Lichen Parmelia Perlata: A Review

Goyal¹,

Verma²,

Sharma³

2016

Int. J. Res. Ayurveda Pharm.

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Parmelia Perlata (Huds.) Ach. belonging to Parmeliaceae family is a lichen (a close symbiotic association between algae and fungi), commonly called 'Stone Flower' and 'Charila' in India. It is widely distributed in hilly areas of Indian subcontinent. The lichen was found to contain several unique chemical constituents like usnic acid, lecaronic acid, salazinic acid, atronin etc and has been traditionally prescribed in bronchitis, excessive salivation, vomiting, toothache, boils, inflammations etc. It has also been indicated in seminal weakness, nocturnal emission, amenorrhoea, leucorrhoea, dyspepsia, calculi, blood and heart diseases, stomach disorders, enlarged spleen, bleeding piles, scabies, leprosy, general pains etc. It tones up the urinary tract and suppresses calculi formation. It has been used as traditional food by Rai and Limbu communities of East Nepal and also as light brown dye for wool as well as bio-indicator of air pollution due to heavy metals. Although it has already been substantiated for antimicrobial, antiurolithiatic, anticancer, antidiabetic potentials etc. yet not fully explored for therapeutic effects and thus remained pharmaceutically unexploited. It is probably due to difficulties in identification, bulk collection and lack of updated scientific reports on lichens. The present manuscript is mainly focused to explain various updated aspects like synonyms, common names, taxonomy, botanical descriptions, traditional uses, chemical constituents, pharmacological activities etc. of P. perlata, and is the first such scientific compilation that can be an important tool for researchers interested in studying this lichen.

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Section: Antioxidant Potentialmentioning

confidence: 99%

“…Methonolic extract of P. perlata was proved to have significant hypolipidemic activity when tested by employing in-vitro anticholesterol assay using Simvastatin as standard 35 .…”

Section: Hypolipidemic Potentialmentioning

confidence: 99%

Pharmacological and Phytochemical Aspects of Lichen Parmelia Perlata: A Review

Goyal¹,

Verma²,

Sharma³

2016

Int. J. Res. Ayurveda Pharm.

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“…root was prepared using maceration methods [14] with a slight modification. The roots were cleaned, cut into small piece and air-dried for at least a week then dried in an oven at 40 °C for 5 h. The dried root was ground.…”

Section: Preparation Of Ethanol Extract Of a Papuana Becc Rootmentioning

confidence: 99%

The cytotoxicity of mekai (Albertisia papuana Becc.) root extract on breast cancer cell lines T47D and Vero cell lines

Kristiani

Nugroho

Moeljopawiro

et al. 2016

AIP Conference Proceedings

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“…Traditionally, P. perlatum has been used to relieve the pain of liver, stomach, renal, lumber region [21], and to manage the diarrhea, abdominal colic, dyspepsia, bronchitis, airway congestion, spermatorrhoea and dysentery [25][26][27][28][29]. P. perlatum possess the anti-diabetic, anti-hyperlipidemic, antiemetic, anti-hypertensive, antifungal, antiurolithiatic, cardiotonic, analgesic, wound healing, cytotoxic, and diuretic activities [21,[30][31][32][33]. Furthermore, caperatic acid and diffractic acid, known constituents of lichens, exhibited the antispasmodic, analgesic, antiviral, antipyretic activities [26,34].…”

Section: Introductionmentioning

confidence: 99%

The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms

et al. 2021

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Parmotremaperlatumis traditionally used in different areas of Pakistan to treat gastrointestinal, respiratory, and vascular diseases. This study evaluates the underlying mechanisms for traditional uses of P. perlatumin diarrhea, asthma, and hypertension. In vitro pharmacological studies were conducted using isolated jejunum, trachea, and aortic preparations, while the cytotoxic study was conducted in mice. Crude extract of P. perlatum(Pp.Cr), comprising appreciable quantities of alkaloids and flavonoids, relaxed spontaneously contracting jejunum preparation, K+ (80 mM)-induced, and carbachol (1 µM)-induced jejunum contractions in a concentration-dependent manner similar to dicyclomine and dantrolene. Pp.Cr showed a rightward parallel shift of concentration-response curves (CRCs) of Cch after a non-parallel shift similarto dicyclomine and shifted CRCs of Ca+2 to rightward much likeverapamil and dantrolene, demonstrating the coexistence of antimuscarinic and Ca+2 antagonistic mechanism. Furthermore, Pp.Cr, dicyclomine, and dantrolene relaxed K+ (80 mM)-induced and Cch (1 µM)-induced tracheal contractions and shifted rightward CRCs of Cch similar to dicyclomine, signifying the dual blockade. Additionally, Pp.Cr also relaxed the K+ (80 mM)-induced and phenylephrine (1 µM)-induced aortic contraction, similarly to verapamil and dantrolene, suggesting Ca+2 channel antagonism. Here, we explored for the first time thespasmolytic and bronchodilator effects of Pp.Crand whether they maybe due to the dual blockade of Ca+2 channels and muscarinic receptors, while the vasodilator effect might be owing to Ca+2 antagonism. Our results provide the pharmacological evidence that P. perlatumcould be a new potential therapeutic option to treat gastrointestinal, respiratory, and vascular diseases. Hence, there is a need for further research to explore bioactive constituent of P. perlatumas well as further investigation by suitable experimental models are required to further confirm the importance and usefulness of P. perlatumin diarrhea, asthma, and hypertension treatment.

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In Vitro Studies on Antioxidant, Hypolipidemic and Cytotoxic Potential of Parmelia Perlata

Cited by 7 publications

References 28 publications

Pharmacological and Phytochemical Aspects of Lichen Parmelia Perlata: A Review

Pharmacological and Phytochemical Aspects of Lichen Parmelia Perlata: A Review

The cytotoxicity of mekai (Albertisia papuana Becc.) root extract on breast cancer cell lines T47D and Vero cell lines

The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms

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