In Vitro Studies on Fibrinogenolysis Induced by Streptokinase

Godal, H. C.; Helle, I

doi:10.3109/00365516309079748

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…The observed effects on the thrombin clotting time of various mixtures of degradation products from purified fibrinogen are in accordance with previous studies (Latallo et al 1964 In c uba t i ont i me ( mlnJ In accordance with previous reports (Al- kjaersig et al 1962, Godal & Helle 1963, Triantaphyllopoulos & Triantaphyllopoulos 1959, the degree of prolongation of the thrombin clotting time depended on the concentration ratio between fibrinogen and the various FDP in the mixture. In addition, the absolute concentration of fibrinogen proved important.…”

Section: Discussionsupporting

confidence: 92%

“…All authors agree that early degradation products prolong the thrombin clotting time to a considerable degree, while the effect of late degradation products is small. It is still not clear, however, whether the anticoagulent effect of FDP is mainly due to inhibition of fibrin polymerization , Godal & Helle 1963, or whether an antithrombin effect is of significant importance (Latallo et al 1964, NilBhn 1967a, Triantaphyllopoulos & Triantaphyllopoulos 1966.…”

Section: Oslo Norwaymentioning

confidence: 99%

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Studies on the Thrombin Clotting Time

Arnesen

Godal

1973

Scandinavian Journal of Haematology

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The influence on the thrombin clotting time of degradation products obtained from soluble or polymerized fibrin was studied. Plasmin degradation of soluble fibrin gave products which markedly prolonged the thrombin clotting time, whereas degradation products from polymerized fibrin (extra clot lysis) were almost inactive. The effect on the thrombin clotting time of degradation products obtained by intra clot lysis varied considerably, dependent on the relative concentrations of thrombin and plasmin used. The present observations stress the importance of a strict definition of fibrin as a source of degradation products, and are also related to the clinical interpretation of the thrombin clotting time.

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Section: Discussionsupporting

confidence: 92%

Section: Oslo Norwaymentioning

confidence: 99%

Studies on the Thrombin Clotting Time

Arnesen

Godal

1973

Scandinavian Journal of Haematology

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“…Fibrinogen degradation products (FDP) have an anticoagulant effect, mainly due to inhibition of fibrin polymerization [ 1,2,8,15]. Early FDP are most potent [19], Incorporation of FDP into fibrin clots increases with the amount present [16], resulting in abnormal clot structure [3] and reduced tensile strength [11], Estimation of plasma fibrinogen and serum FDP are important in fibrin olytic states.…”

Section: Introductionmentioning

confidence: 99%

Influence of pH on the Incorporation of Fibrinogen Degradation Products into Fibrin Clots as Studied by Tracer Technique

Ly¹,

Arnesen²

1973

Pathophysiol Haemos Thromb

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Fibrinogen degradation products (FDP) interfere with coagulation of fibrinogen and may lead to incorrect estimates of fibrinogen in plasma and of FDP in serum. At pH 7.8 as much as 50–60 % of early FDP were incorporated into clots made from whole blood or from plasma, whereas late FDP were incorporated to minor extent. By lowering pH to 6.3, incorporation of early FDP was markedly reduced. The amount of unclotted fibrin due to the presence of FDP was also reduced. Thus, for a more correct estimate of FDP in serum, it is suggested that pH of blood or plasma should be lowered prior to clotting. Estimation of fibrinogen according to the Jacobsson assay (pH 6.3) is fairly exact in the presence of FDP, except at very high FDP concentrations.

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“…Godal & Helle 1963, Hirsh et al 1965. Fibrinogen assays based on clot formation, therefore, may give erroneous results in .the presence of FDP.…”

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confidence: 99%

Quantitation of Plasma Fibrinogen in the Presence of Fibrinogen Degradation Products

Arnesen

1973

Scandinavian Journal of Haematology

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Three methods for fibrinogen determination in plasma were compared as to their reliability in the presence of fibrinogen degradation products (FDP). The method of Clauss gave erroneously low values, the semiquantitative method of Schneider was less influenced by FDP, whereas the method of Jacobsson gave fairly accurate results. Additional experiments suggested that dilution of the test plasma was responsible for the very low values obtained with the method of Clauss, whereas the final pH of 6.4 in the method of Jacobsson was found to be critical for the limited effect of FDP in this assay.

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In Vitro Studies on Fibrinogenolysis Induced by Streptokinase

Cited by 10 publications

References 7 publications

Studies on the Thrombin Clotting Time

Studies on the Thrombin Clotting Time

Influence of pH on the Incorporation of Fibrinogen Degradation Products into Fibrin Clots as Studied by Tracer Technique

Quantitation of Plasma Fibrinogen in the Presence of Fibrinogen Degradation Products

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