In vitro study of 3D PLGA/n-HAp/β-TCP composite scaffolds with etched oxygen plasma surface modification in bone tissue engineering

Roh, Hee-Sang; Jung, Sang‐Chul; Kook, Min-Suk; Kim, Byung–Hoon

doi:10.1016/j.apsusc.2015.12.243

Cited by 50 publications

(43 citation statements)

References 32 publications

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“…Different printing technologies were used to develop 3D scaffolds for bone tissue engineering applications (Table ). Fused Deposition Modeling was the most frequently used printing technology as it was employed in 38 studies (Figure ) . Low‐temperature deposition manufacturing was used in 11 studies, selective laser sintering in seven studies, Stereolitography in three studies …”

Section: Resultsmentioning

confidence: 99%

“…PCL was the most used polymer as it was found in 29 articles . PLA was used in 13 studies and PLGA in 14 studies . Polyethylene glycol (PEG) was also used in six studies but not as major polymer: it was mixed with PLA, PCL, or with polyoxyethylene terephthalate and polybutylene terephthalate (PEOT/PBT) .…”

Section: Resultsmentioning

confidence: 99%

“…TCP was the most frequent and it was used in 32 studies . HA was the second most used mineral, in its non‐modified form in 25 studies, its carbonated form in two studies, its sintered form in one study or just as an apatite coating in two studies . In two cases, HA and TCP were mixed together to obtain biphasic calcium phosphate (BCP) .…”

Section: Resultsmentioning

confidence: 99%

“…Fourier transform infrared spectroscopy (FTIR) was used in five studies, Raman spectroscopy in two studies, X‐ray photoelectron spectroscopy (XPS) was used in two studies, and Carbon 13 nuclear resonance ( 13 C‐NMR) in one study . X‐ray diffraction (XRD) was used in three studies and was also used to collect information about crystallinity . Energy‐dispersive X‐ray spectroscopy (EDX) was found in eight studies .…”

Section: Resultsmentioning

confidence: 99%

“…The addition of calcium phosphate (CaP) has also an impact on material roughness. Furthermore, it has been shown that CaP incorporation into a polymer can increase wettability of the scaffold . Increasing wettability leads to more hydrophilic material surface.…”

Section: Introductionmentioning

confidence: 99%

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3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

et al. 2019

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Applications in additive manufacturing technologies for bone tissue engineering applications requires the development of new biomaterials formulations. Different three‐dimensional (3D) printing technologies can be used and polymers are commonly employed to fabricate 3D printed bone scaffolds. However, these materials used alone do not possess an effective osteopromotive potential for bone regeneration. A growing number of studies report the combination of polymers with minerals in order to improve their bioactivity. This review exposes the state‐of‐the‐art of existing 3D printed composite biomaterials combining polymers and minerals for bone tissue engineering. Characterization techniques to assess scaffold properties are also discussed. Several parameters must be considered to fabricate a 3D printed material for bone repair (3D printing method, type of polymer/mineral combination and ratio) because all of them affect final properties of the material. Each polymer and mineral has its own advantages and drawbacks and numerous composites are described in the literature. Each component of these composite materials brings specific properties and their combination can improve the biological integration of the 3D printed scaffold. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2579–2595, 2019.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

et al. 2019

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Osteoporotic Bone Recovery by a Highly Bone‐Inductive Calcium Phosphate Polymer‐Induced Liquid‐Precursor

Yao

Lin

et al. 2019

Advanced Science

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Osteoporosis is an incurable chronic disease characterized by a lack of mineral mass in the bones. Here, the full recovery of osteoporotic bone is achieved by using a calcium phosphate polymer‐induced liquid‐precursor (CaP‐PILP). This free‐flowing CaP‐PILP material displays excellent bone inductivity and is able to readily penetrate into collagen fibrils and form intrafibrillar hydroxyapatite crystals oriented along the c‐axis. This ability is attributed to the microstructure of the material, which consists of homogeneously distributed ultrasmall (≈1 nm) amorphous calcium phosphate clusters. In vitro study shows the strong affinity of CaP‐PILP to osteoporotic bone, which can be uniformly distributed throughout the bone tissue to significantly increase the bone density. In vivo experiments show that the repaired bones exhibit satisfactory mechanical performance comparable with normal ones, following a promising treatment of osteoporosis by using CaP‐PILP. The discovery provides insight into the structure and property of biological nanocluster materials and their potential for hard tissue repair.

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Effect of β‐tricalcium phosphate on the thermal foaming behavior of poly(vinyl alcohol)/water system

Zhu

Wang

2017

J of Applied Polymer Sci

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Poly(vinyl alcohol) (PVA)/b-tricalcium phosphate (b-TCP, Ca 3 (PO 4 ) 2 ) porous composite, which has potential application in articular cartilage repair, was prepared through thermal foaming using water as both plasticizer and physical blowing agent. The effects of b-TCP content on the foaming behavior, the structure and properties of the porous composites were studied. The results showed that b-TCP could form hydrogen bonds or coordination interaction with PVA and water; with the incorporation of b-TCP, the content of nonfreezable bound water in system increased, the water evaporation reduced, beneficial to the controllable foaming of water. The interactions between PVA-b-TCP led to the enhanced melt viscosity of PVA. Simultaneously, the b-TCP particles in matrix could act as heterogeneous nucleation agent to increase the cell density. When b-TCP content was 7.4 wt %, the porous composite showed the optimal cell structure, i.e., 250 lm average cell size and 87% porosity. The dynamic modulus of the porous composites increased with b-TCP content and showed frequency-dependence. The surface contact angle and permeability of the porous composites varied with b-TCP content, which ranged from 358 to 488 and 11 3 10 214 to 27 3 10 214 m 2 , respectively. V C 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44737.

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In vitro study of 3D PLGA/n-HAp/β-TCP composite scaffolds with etched oxygen plasma surface modification in bone tissue engineering

Cited by 50 publications

References 32 publications

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

Osteoporotic Bone Recovery by a Highly Bone‐Inductive Calcium Phosphate Polymer‐Induced Liquid‐Precursor

Effect of β‐tricalcium phosphate on the thermal foaming behavior of poly(vinyl alcohol)/water system

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