In vitro study of dual layer mixed matrix hollow fiber membranes for outside-in filtration of human blood plasma

Beek, O.E.M. ter; Gelder, Maaike K. van; Lokhorst, C.; Hazenbrink, Diënty H. M.; Lentferink, B.H.; Gerritsen, Karin G.F.; Stamatialis, Dimitrios

doi:10.1016/j.actbio.2020.12.063

Cited by 23 publications

(19 citation statements)

References 26 publications

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“…Solute concentrations were determined in the permeate and feed samples using a UV-Vis spectrophotometer (UV-1700 PharmaSpec, Shimadzu, Japan), according to each toxin's wavelength of maximum absorbance, λmax: 200, 230, and 293 nm for urea [40], creatinine [41], and uric acid [42], respectively.…”

Section: Rejection Coefficients To Low-molecular Weight Water-soluble Uremic Toxinsmentioning

confidence: 99%

Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions

et al. 2021

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A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO2-(CH2)3NH2 membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques. Morphological characterization was performed by scanning electron microscopy (SEM), and the chemical composition was analyzed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR). The characterization of the monophasic hybrid CA-SiO2-(CH2)3NH2 membrane in terms of permeation properties was carried out in an in-house-built single hemodialysis membrane module (SHDMM) under dynamic conditions. Permeation experiments were performed to determine the hydraulic permeability (Lp), molecular weight cut-off (MWCO) and the rejection coefficients to urea, creatinine, uric acid, and albumin. SEM confirmed the existence of a very thin (<1 µm) top dense layer and a much thicker bottom porous surface, and ATR-FTIR showed the main bands belonging to the CA-based membranes. Permeation studies revealed that the Lp and MWCO of the CA-SiO2-(CH2)3NH2 membrane were 66.61 kg·h−1·m−2·bar−1 and 24.5 kDa, respectively, and that the Lp was 1.8 times higher compared to a pure CA membrane. Furthermore, the CA-SiO2-(CH2)3NH2 membrane fully permeated urea, creatinine, and uric acid while completely retaining albumin. Long-term filtration studies of albumin solutions indicated that fouling does not occur at the surface of the CA-SiO2-(CH2)3NH2 membrane.

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Section: Rejection Coefficients To Low-molecular Weight Water-soluble Uremic Toxinsmentioning

confidence: 99%

Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions

et al. 2021

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“…Development of the dual-layer MMMs began in 2012 by Tijink et al [ 37 ] with the production of the membranes in the form of flat sheets followed shortly by three different types of hollow fibers where blood circulated on the inside of the fibers and dialysate on the outside [ 38 , 39 , 40 ]. More recently, Beek et al [ 41 ], prepared dual-layer hollow fibers intended for outside-in filtration (OIF) or extraluminal flow therapy, where the blood flows on the outside of the hollow fibers while dialysate flows in the lumen. Figure 2 shows a scheme of the five different PES/PVP-AC MMMs developed over the last decade.…”

Section: Adsorptive Membranesmentioning

confidence: 99%

“…The most recent generation of dual-layer PES/PVP-AC-based hollow fibers, MMM-OIF, developed by ter Beek at al. [ 41 ] introduced a new concept of circulation mode—the outside-in filtration (OIF) or extraluminal flow therapy, where the blood/plasma flows on the outside of the hollow fibers while dialysate flows in the lumen. In these membranes, the dense, thin, and particle-free layer is on the outside of the fiber while the inner side (lumen) is composed of the thicker and porous layer containing the AC particles.…”

Section: Adsorptive Membranesmentioning

confidence: 99%

Adsorption- and Displacement-Based Approaches for the Removal of Protein-Bound Uremic Toxins

Rodrigues

Faria

2023

Toxins

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End-stage renal disease (ESRD) patients rely on renal replacement therapies to survive. Hemodialysis (HD), the most widely applied treatment, is responsible for the removal of excess fluid and uremic toxins (UTs) from blood, particularly those with low molecular weight (MW < 500 Da). The development of high-flux membranes and more efficient treatment modes, such as hemodiafiltration, have resulted in improved removal rates of UTs in the middle molecular weight range. However, the concentrations of protein-bound uremic toxins (PBUTs) remain essentially untouched. Due to the high binding affinity to large proteins, such as albumin, PBUTs form large complexes (MW > 66 kDa) which are not removed during HD and their accumulation has been strongly associated with the increased morbidity and mortality of patients with ESRD. In this review, we describe adsorption- and displacement-based approaches currently being studied to enhance the removal of PBUTs. The development of mixed matrix membranes (MMMs) with selective adsorption properties, infusion of compounds capable of displacing UTs from their binding site on albumin, and competitive binding membranes show promising results, but the road to clinical application is still long, and further investigation is required.

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“…61 The performance of mixed matrix membranes could potentially be enhanced by an "outsidein" design, with dialysate flowing through hollow fibers while blood flows outside the fibers. 62 While activated carbon has been the sorbent most commonly considered for addition to the dialysate stream, other materials could provide special benefits or greater safety. 45,[63][64][65] Addition of lipids to the dialysate was initially evaluated as a means to improve removal of drugs which bind to both lipids and plasma proteins.…”

Section: Protein-bound Solutesmentioning

confidence: 99%

Improving Clearance for Renal Replacement Therapy

2021

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The adequacy of hemodialysis is now assessed by measuring the removal of the single solute urea. The urea clearance provided by current dialysis methods is a large fraction of the blood flow through the dialyzer, and therefore cannot be increased much further. Other solutes which are less effectively cleared than urea may however contribute more to the residual uremic illness suffered by hemodialysis patients. We here review a variety of methods which could be employed to increase the clearance of such non-urea solutes. New clinical studies will be required to test the extent to which increasing solute clearances improves patients' health.

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In vitro study of dual layer mixed matrix hollow fiber membranes for outside-in filtration of human blood plasma

Cited by 23 publications

References 26 publications

Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions

Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions

Adsorption- and Displacement-Based Approaches for the Removal of Protein-Bound Uremic Toxins

Improving Clearance for Renal Replacement Therapy

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