In vitro study of low-frequency ultrasound-enhanced transdermal transport of fentanyl and caffeine across human and hairless rat skin

Boucaud, Alain; Machet, L.; Arbeille, B.; Machet, M.C.; Sournac, Michel; Mavon, Alain; Patat, F.; Vaillant, L.

doi:10.1016/s0378-5173(01)00820-1

Cited by 80 publications

(38 citation statements)

References 21 publications

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“…In an important study, Boucaud and co-workers [26, 27] also used a 20kHz output with a 10% duty cycle and found that this beam facilitated a 3.73-fold increase in caffeine permeation across dermatomed human skin. However, this was achieved by using a SATA intensity of 2.5W/cm 2 and sonicating for a full hour.…”

Section: Discussionmentioning

confidence: 99%

Development of an Optimised Application Protocol For Sonophoretic Transdermal Delivery of a Model Hydrophilic Drug

Sarheed

Rasool²

2011

TOBEJ

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It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis. Mechanistically, acoustic cavitation results in the creation of defects in the stratum corneum that allow accelerated absorption of topically applied molecules. The aim of this study was to develop an optimised sonophoresis protocol for studying transdermal drug delivery in vitro. To this end, caffeine was selected as a model hydrophilic drug while porcine skin was used as a model barrier. Following acoustic validation, 20kHz ultrasound was applied for different durations (range: 5 s to 10 min) using three different modes (10%, 33% or 100% duty cycles) and two distinct sonication procedures (either before or concurrent with drug deposition). Each ultrasonic protocol was assessed in terms of its heating and caffeine flux-enhancing effects. It was found that the best regimen was a concurrent 5 min, pulsed (10% duty cycle) beam of SATA intensity 0.37 W/cm2. A key insight was that in the case of pulsed beams of 10% duty cycle, sonication concurrent with drug deposition was superior to sonication prior to drug deposition and potential mechanisms for this are discussed.

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Section: Discussionmentioning

confidence: 99%

Development of an Optimised Application Protocol For Sonophoretic Transdermal Delivery of a Model Hydrophilic Drug

Sarheed

Rasool²

2011

TOBEJ

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“…Further, it is also used in medical fields [8][9][10] . The ultrasonic measurements have also been used to study molecular interactions in various pure liquids 11 , liquid mixtures 12,13 and solutions of organic and inorganic compounds [14][15][16] , polymers 17 , amino acids 18 , drugs 19 etc.…”

Section: Introductionmentioning

confidence: 99%

Acoustical Studies of some Chalcones in DMF and DMSO Solutions

Baluja

Kasundra

2015

ILCPA

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“…Ultrasound at various frequencies has been used to enhance skin permeability (12)(13)(14)(15)(16) for non-invasive transdermal drug delivery (17)(18)(19)(20)(21)(22)(23) and transdermal monitoring (24)(25)(26)(27) in in vitro, in vivo, and clinical studies. The proposed mechanisms described for this phenomenon are inertial cavitations (and induced acoustic streaming) in the ultrasound's coupling medium (28,29), and rectified diffusion inside the skin layers (30).…”

Section: Introductionmentioning

confidence: 99%

Fetal Membrane Transport Enhancement Using Ultrasound for Drug Delivery and Noninvasive Detection

et al. 2014

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In vitro study of low-frequency ultrasound-enhanced transdermal transport of fentanyl and caffeine across human and hairless rat skin

Cited by 80 publications

References 21 publications

Development of an Optimised Application Protocol For Sonophoretic Transdermal Delivery of a Model Hydrophilic Drug

Development of an Optimised Application Protocol For Sonophoretic Transdermal Delivery of a Model Hydrophilic Drug

Acoustical Studies of some Chalcones in DMF and DMSO Solutions

Fetal Membrane Transport Enhancement Using Ultrasound for Drug Delivery and Noninvasive Detection

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