In vitro study of toxicity of hybrid gold-polymer composites

Kutsevol, N.; Kuziv, Yuliia; Shton, Irina; Borikun, T V; Storchai, D M; Lukianova, N Yu; Чехун, В Ф

doi:10.1080/15421406.2018.1542078

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…These polymers were used as a base for the creation of the hybrid composites containing gold nanoparticles. The systems obtained were examined against breast cancer MCF-7 cell line and MT-4 (human T-cell leukemia) cell line [28]. The results proved low in vitro toxicity of examined composite like Polymer/AuNP sample even in high doses.…”

Section: Resultsmentioning

confidence: 94%

Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy

Kutsevol

Kuziv

Bezugla

et al. 2020

International Journal of Polymer Science

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Multicomponent nanocomposites for anticancer therapy were prepared, characterized, and tested for their antitumor efficacy. The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photodynamic and combined (photodynamic+chemotherapy) antitumor therapy. The three-component nanocomposites with incorporated gold nanoparticles and photosensitizer and the four-component ones additionally loaded by Doxorubicin into polymer nanoplatform were studied at 25 and 37°C by transmission electron microscopy and dynamic light scattering. Nanocomposites were tested for their photodynamic cytotoxicity for the cell line of breast cancer MCF-7/S. Three-component nanocomposites demonstrated higher efficacy than the four-component ones. The decrease in the activity of the four-component systems is explained by the aggregation process caused by the introduction of an additional component, which leads to a decrease in the hydrophilic-hydrophobic balance of the polymer macromolecule.

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Section: Resultsmentioning

confidence: 94%

Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy

Kutsevol

Kuziv

Bezugla

et al. 2020

International Journal of Polymer Science

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“…They have lower toxicity compared to silver NPs. 11,12 In addition, a promising approach is to use Au NPs in addition to localized surface plasmon resonance (LSPR). This phenomenon, in which the free electrons in metal NPs oscillate collectively when irradiated with light resonant with the LSPR frequency, causes a frequency-dependent plasmonic enhancement effect.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic enhancement of the antibacterial photodynamic efficiency of a zinc tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles hybrid nanosystem

et al. 2022

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“…Gold nanoparticles (Au NPs) are widely used in many biological applications. They are less toxic than Ag NPs [ 38 , 39 ]. Recently, the high antitumor efficiency has been demonstrated for some gold-based compounds [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Zinc TetraPhenylPorphyrin Photosensitizer/Dextran Graft Poly(N-IsoPropylAcrylAmide) Copolymer/Au Nanoparticles Hybrid Nanosystem: Potential for Photodynamic Therapy Applications

et al. 2022

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The thermoresponsive Zinc TetraPhenylPorphyrin photosensitizer/Dextran poly (N-isopropylacrylamide) graft copolymer/Au Nanoparticles (ZnTPP/D-g-PNIPAM/AuNPs) triple hybrid nanosystem was synthesized in aqueous solution as a nanodrug for potential use in thermally driven and controlled photodynamic therapy applications. The aqueous solution of the nanosystem has demonstrated excellent stability in terms of aggregation and sedimentation several days after preparation. Optimal concentrations of the components of hybrid nanosystem providing the lowest level of aggregation and the highest plasmonic enhancement of electronic processes in the photosensitizer molecules have been determined. It has been revealed that the shrinking of D-g-PNIPAM macromolecule during a thermally induced phase transition leads to the release of both ZnTPP molecules and Au NPs from the ZnTPP/D-g-PNIPAM/AuNPs macromolecule and the strengthening of plasmonic enhancement of the electronic processes in ZnTPP molecules bound with the polymer macromolecule. The 2.7-fold enhancement of singlet oxygen photogeneration under resonant with surface plasmon resonance has been observed for ZnTPP/D-g-PNIPAM/AuNPs proving the plasmon nature of such effect. The data obtained in vitro on wild strains of Staphylococcus aureus have proved the high potential of such nanosystem for rapid photodynamic inactivation of microorganisms particular in wounds or ulcers on the body surface.

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In vitro study of toxicity of hybrid gold-polymer composites

Cited by 6 publications

References 9 publications

Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy

Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy

Plasmonic enhancement of the antibacterial photodynamic efficiency of a zinc tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles hybrid nanosystem

Thermoresponsive Zinc TetraPhenylPorphyrin Photosensitizer/Dextran Graft Poly(N-IsoPropylAcrylAmide) Copolymer/Au Nanoparticles Hybrid Nanosystem: Potential for Photodynamic Therapy Applications

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