In Vitro Study on Smart Stent for Autonomous Post-Endovascular Aneurysm Repair Surveillance

Abstract

Endovascular aneurysm repair (EVAR) is an established and reliable surgical treatment of abdominal aortic aneurysm (AAA), where a covered stent is implanted to prevent blood flow in the aneurysm sac. Although current EVAR is an effective technique, it requires long-term monitoring for the post-operative complications (e.g., endoleak, stent occlusion), which usually requires expensive radiologic imaging techniques such as ultrasonography, computed tomography (CT), or magnetic resonance imaging (MRI). In this paper, we present an accessible and continuous post-EVAR surveillance scheme by developing a smart stent that features ultrasonic powering, blood flow sensing, and integrated wireless electronics. As the body of the smart stent, a piezoelectric membrane with a custom pore architecture is utilized. The benefits of the embedded pore architectures include the expansion and contraction to comply with a minimally invasive procedure and enhanced ultrasonic powering and sensing capability. The smart stent is able to expand up to 112% in diameter when stretched due to the negative Poisson's ratio. The ultrasound generates 0.23 mW of electrical power, which can sufficiently operate a low power wireless electronics. A comprehensive operation of the smart stent is demonstrated in vitro. The integrated flow sensor can measure blood flow ranging between 30 mL/min to 980 mL/min with an average sensitivity of 0.11 mV/mL/min. The wireless electronics transmit and receive such blood flow rate data by modulating the carrier frequency from 81 to 88 MHz from 1 m away. The developed smart stent prototype is the first step towards minimizing post-EVAR complications by providing early and frequent access to diagnostic information to patients and physicians.

Haemodynamics of stent-mounted neural interfaces in tapered and deformed blood vessels

“…Currently, stent technology has been utilized beyond its traditional purposes, such as the SMART stent (stent with flow or pressure sensors) 47 , 48 and stents with recording electrodes 49 . By adding sensors and electrodes, stents are empowered with more functions to serve as potential new or better treatment options for intractable diseases.…”

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

“…The smart stent can generate 0.23 mW of electrical power when exposed to ultrasonic stimulation, which can sufficiently operate low‐power wireless electronics. [ 237 ] In another study, GO was added to PVDF via laser sintering to enhance its piezoelectric effect. The results indicated that the PVDF/0.3GO scaffold presented the best electrical performance, and the proliferation of cells cultured on this scaffold can be effectively enhanced when exposed to ultrasound.…”

“…Copyright 2014, Wiley-VCH. d) Reproduced with permission [237]. Copyright 2020, Institute of Electrical and Electronics Engineers Inc.…”