In vitro study on the antitumor activity of several new polyoxometalates

Abstract

Polyoxometalates ( POMs ) are negatively charged clusters consisting of transition metals and oxygen atoms. There are two general types of POM activity, antiviral and antitumoral, have dominated the medicinal chemistry of these compounds. Based on synthesized four different kind of POMs, [Ce(H 2 O) 7 Cr(OH) 6 Mo 6 O 18 ] n ·4nH 2 O, [Sm(H 2 O) 7 Cr(OH) 6 Mo 6 O 18 ] n ·4nH 2 O, Eu(H 2 O) 7 Cr(OH) 6-Mo 6 O 18 ] n ·4nH 2 O, and K 6 [P 2 W 18 O 62 ]·14H 2 O, we investigate their antitumor effect in vitro. K 6 [P 2 W 18 O 62 ]·14H 2 O exerted the most strong activity. IC 50 of it for MCF-7, SKOV-3 and HepG2 were 22 mol/L,19 mol/L and 24 mol/L respectively. Lower concentration of K 6 [P 2 W 18 O 62 ]·14H 2 O could induce HepG2 cells apoptosis . It up-regulated the expression of Bax and Bim , apoptosis promoting members in Bcl-2 family,so the mechanism of this effect may through mitochondria path way.