In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose

Tang, Daoquan; Wei, Yaqing; Yin, Xiaoxing; Lü, Qian; Hao, Huihui; Zhai, Yunpeng; Wang, Jianyun; Ren, Jin

doi:10.1016/j.fitote.2011.05.001

Cited by 24 publications

(17 citation statements)

References 38 publications

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“…It suppressed glomerular mesangial cell hypertrophy, proliferation, and extracellular matrix accumulation, all of which occur in glomerular sclerosis [24]. Proposed mechanisms of action include inhibition of transforming growth factor- β 1 (TGF- β 1) expression [25] and amelioration of oxidative stress [26], which have been shown to be final common mediators of renal injury in diabetes [27].…”

Section: Resultsmentioning

confidence: 99%

Text Mining of the Classical Medical Literature for Medicines That Show Potential in Diabetic Nephropathy

Zhang¹,

Yin

Guo³

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Objectives. To apply modern text-mining methods to identify candidate herbs and formulae for the treatment of diabetic nephropathy. Methods. The method we developed includes three steps: (1) identification of candidate ancient terms; (2) systemic search and assessment of medical records written in classical Chinese; (3) preliminary evaluation of the effect and safety of candidates. Results. Ancient terms Xia Xiao, Shen Xiao, and Xiao Shen were determined as the most likely to correspond with diabetic nephropathy and used in text mining. A total of 80 Chinese formulae for treating conditions congruent with diabetic nephropathy recorded in medical books from Tang Dynasty to Qing Dynasty were collected. Sao si tang (also called Reeling Silk Decoction) was chosen to show the process of preliminary evaluation of the candidates. It had promising potential for development as new agent for the treatment of diabetic nephropathy. However, further investigations about the safety to patients with renal insufficiency are still needed. Conclusions. The methods developed in this study offer a targeted approach to identifying traditional herbs and/or formulae as candidates for further investigation in the search for new drugs for modern disease. However, more effort is still required to improve our techniques, especially with regard to compound formulae.

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Section: Resultsmentioning

confidence: 99%

Text Mining of the Classical Medical Literature for Medicines That Show Potential in Diabetic Nephropathy

Zhang¹,

Yin

Guo³

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…It significantly decreased the cell percentages of G(0)/G(1) phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-β(1) mRNA level. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin 22 . Li XH and coworkers evaluated the effectiveness of Pentamethyl quercetin (PMQ) for ameliorating diabetes-related cognitive dysfunction in vivo and in vitro.…”

Section: Quercetinmentioning

confidence: 93%

Untitled

2016

IJPSR

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Type 2 diabetes is a serious health problem globally. In type 2 diabetes insulin resistance in various tissues such as liver, muscle and β-cell is the major pathophysiological defects. People with long term uncontrolled hyperglycemia are at risk of developing a number of serious and life-threatening complications which mainly affect the heart and blood vessels, eyes, kidneys, and nerves. Current drug development strategy has focused towards the control of hyperglycemia but the treatment of severe complications has been neglected. Many herbs including Momordica charantia, Coccinia indica, Ficus carica, Gymnema sylvestre, Ocimum santum and many more have traditionally been used for the treatment of diabetes and associated complications. Natural products have been reported to have their efficacy in diabetes and its complications by protecting pancreatic β-cells, increasing insulin sensitivity, reducing oxidative stress and by targeting various proteins. Thus, now a day plant based natural product (phytoconstituents) have been the basis of drug development program for the treatment of various diseases. The present review summarizes the latest updates on phytochemicals from different class of secondary metabolites with potential effect in type 2 diabetic complications.

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“…37 Quercetin downregulated Twist1 and simultaneously increased the level of E-cadherin. 39 Moreover, how quercetin regulates SMADspecific-E3 ubiquitin protein ligases, SMURF1 and SMURF2, in various cancers also need to be demystified. 37 It seems astonishing to note that quercetin-mediated effects have been extensively studied, but we still have incomplete knowledge related to the regulation of signal transducers of TGF pathway.…”

Section: Regulation Of Tgf/smad and Shh/gli Signaling By Quercetin:mentioning

confidence: 99%

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Farooqı

Jabeen

Attar

et al. 2018

J of Cellular Biochemistry

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Recent technological and analytical breakthroughs in genomics and proteomics have deepened our understanding related to the multifaceted nature of cancer. Because of therapeutically challenging nature of cancer, there has been a renewed interest in phytochemistry, and much attention is currently being given to the identification of signaling pathway inhibitors. Data obtained through high-throughput technologies has provided a broader landscape of wiring maps of complex oncogenic signaling networks, thus revealing novel therapeutic opportunities. Increasingly, it is being realized that although our knowledge related to physiological and pathophysiological roles of signal transduction cascades has evolved rapidly, the clinical development of signaling pathway inhibitors has been challenging. Quercetin has attracted considerable attention because of its amazingly high pharmacological value. Research over decades has sequentially shown that quercetin effectively inhibited cancer development and progression. In this review, we have attempted to set the spotlight on the regulation of different cell signaling pathways by quercetin. We partition this multicomponent review into how quercetin effectively regulates the Wnt/β-catenin pathway, Janus kinase-signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers. We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin. MicroRNAs (miRNAs) have also emerged as versatile regulators of cancer, and contemporary studies have shed light on the ability of quercetin to control different miRNAs in various cancers. We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.

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In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose

Cited by 24 publications

References 38 publications

Text Mining of the Classical Medical Literature for Medicines That Show Potential in Diabetic Nephropathy

Text Mining of the Classical Medical Literature for Medicines That Show Potential in Diabetic Nephropathy

Untitled

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

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