2004
DOI: 10.1128/aac.48.11.4470-4472.2004
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In Vitro Susceptibilities of Mycoplasma hyopneumoniae Field Isolates

Abstract: The in vitro susceptibilities of 21 Mycoplasma hyopneumoniae field isolates were determined using a broth microdilution technique. One isolate showed acquired resistance to lincomycin, tilmicosin, and tylosin, while five isolates were resistant to flumequine and enrofloxacin. Acquired resistance against these antimicrobials in M. hyopneumoniae field isolates was not reported previously.Mycoplasma hyopneumoniae causes enzootic pneumonia, a chronic respiratory disease in pigs resulting in considerable economic l… Show more

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Cited by 49 publications
(53 citation statements)
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“…It was followed by tiamulin, lincomycin, and tilmicosin with MIC 90 values of 0.25 µg/mL, 1 µg/mL and 4 µg/mL, respectively. As with the Mhp isolates, chlortetracycline was also less active against the Mhr field isolates with MIC range from 4 to 64 µg/mL and MIC 90 of 64 µg/mL.For the Mhp field isolates, MIC 90 values of tylvalosin, tiamulin and chlortetracycline were consistent with the previous studies [8][9][10] [6,11]. Tylvalosin, which had an in vitro activity up to thousand times higher compared to other antibiotics, showed highest efficacy against both mycoplasma species.…”
supporting
confidence: 86%
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“…It was followed by tiamulin, lincomycin, and tilmicosin with MIC 90 values of 0.25 µg/mL, 1 µg/mL and 4 µg/mL, respectively. As with the Mhp isolates, chlortetracycline was also less active against the Mhr field isolates with MIC range from 4 to 64 µg/mL and MIC 90 of 64 µg/mL.For the Mhp field isolates, MIC 90 values of tylvalosin, tiamulin and chlortetracycline were consistent with the previous studies [8][9][10] [6,11]. Tylvalosin, which had an in vitro activity up to thousand times higher compared to other antibiotics, showed highest efficacy against both mycoplasma species.…”
supporting
confidence: 86%
“…Therefore, use of antimicrobials often becomes necessary to limit the disease in the event of outbreak or as an additional measure to prevent mycoplasma disease. Although considerable data have been obtained on the in vitro antibiotic susceptibility of Mhp and Mhr around the world [6,[8][9][10][11], there are few reports about their susceptibility, and to our knowledge, there is no recent information on antibiotic susceptibility of these mycoplasmas from Korea. In the present study, minimum inhibitory concentrations (MICs) of Korea Mhp and Mhr isolates to tylvalosin and other commonly used antibiotics (tiamulin, lincomycin, tilmicosin and chlortetracycline) was determined.…”
mentioning
confidence: 99%
“…In Thailand, antimicrobials are generally given to piglets to control diarrhea and respiratory problems during weaning to fattening as well as to gilt and sow during gilt acclimatization and lactation [15]. Excessive medication may cause a decrease of susceptibility of mycoplasmas against antimicrobial agents [11,21,23]. To date, antimicrobial resistance of porcine mycoplasmas has been reported to tetracyclines, macrolides, lincomycin and flumequine, the first generation fluoroquinolone in some countries [1,6,17,21,22].…”
mentioning
confidence: 99%
“…Excessive medication may cause a decrease of susceptibility of mycoplasmas against antimicrobial agents [11,21,23]. To date, antimicrobial resistance of porcine mycoplasmas has been reported to tetracyclines, macrolides, lincomycin and flumequine, the first generation fluoroquinolone in some countries [1,6,17,21,22]. In Thailand, susceptibility of M. hyopneumoniae to antimicrobial agents was investigated for the isolates collected in 1997-1998, and no resistant isolates were found in that period [14].…”
mentioning
confidence: 99%
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