In Vitro Susceptibility of
            <i>Ureaplasma urealyticum</i>
            to Rosaramicin

Smith, Thomas F.

doi:10.1128/aac.16.1.106

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Other reported MICs are for wildtype strains. Although the absolute values of MICs may vary, general patterns emerge: the median MIC of tetracycline is less than that for erythromycin (2,10,27), and rosaramicin is decidedly more active than erythromycin (11,24). We found the same results in our study (Fig.…”

Section: Resultssupporting

confidence: 81%

Standardized method for determining antimicrobial susceptibility of strains of Ureaplasma urealyticum and their response to tetracycline, erythromycin, and rosaramicin

Robertson¹,

Coppola²,

Heisler³

1981

Antimicrob Agents Chemother

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We describe a method for determining the miniimal inhibitory concentrations (MICs) of antibiotics for Ureaplasma urealyticum which is compatible with current standards of susceptibility testing. A presumptive MIC is available after 24 h of incubation, and the definitive MIC is available at 48 h. The MICs for 9 serotype strains and 27 clinical isolates ranged from O0.5 to 256 pg of tetracycline per ml, cl to 64 ,ug of erythromycin per ml, and 0.031 to 4.0 ,ug of rosaramicin per ml. Of an additional 555 isolates screened for their response to tetracycline, 2% required MICs of greater than 64 pg/ml, which we believe is near the concentration at which in vivo resistance to this agent is expressed. After prolonged exposure to rosaramicin, the resistance of two of three serotype strains of U. urealyticum was increased 8-and 16-fold, but the MICs still did not exceed 1.0 Ag/ml.

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Section: Resultssupporting

confidence: 81%

Standardized method for determining antimicrobial susceptibility of strains of Ureaplasma urealyticum and their response to tetracycline, erythromycin, and rosaramicin

Robertson¹,

Coppola²,

Heisler³

1981

Antimicrob Agents Chemother

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“…urealyticum tests. Susceptibility tests were performed by a broth dilution method (20) with Boston broth S2 (11). Twofold serial concentrations of the antimicrobial drugs were incorporated into the medium.…”

Section: Methodsmentioning

confidence: 99%

Activities of new quinoline derivatives against genital pathogens

Aznar¹,

Caballero²,

Lozano³

et al. 1985

Antimicrob Agents Chemother

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The in vitro activities of four quinoline carboxylic acids against 48 strains of Neisseria gonorrhoeae, 10 of Chlamydia trachomatis, and 32 of Ureaplasma urealyticum were compared. Ciprofloxacin was the most active against N. gonorrhoeae and C. trachomatis but had poor bactericidal activity against U. urealyticum, whereas ofloxacin showed the most bactericidal activity against U. urealyticum but was less active than ciprofloxacin against the two former pathogens. Norfloxacin and enoxacin were less active against all the studied pathogens.

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Mycoplasmas

Smith¹

1981

Laboratory Procedures in Clinical Microbiology

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In Vitro Susceptibility of Ureaplasma urealyticum to Rosaramicin

Cited by 7 publications

References 19 publications

Standardized method for determining antimicrobial susceptibility of strains of Ureaplasma urealyticum and their response to tetracycline, erythromycin, and rosaramicin

Standardized method for determining antimicrobial susceptibility of strains of Ureaplasma urealyticum and their response to tetracycline, erythromycin, and rosaramicin

Activities of new quinoline derivatives against genital pathogens

Mycoplasmas

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