In vitro susceptibility of multi-drug resistant Pseudomonas aeruginosa and extended-spectrum β-lactamase–producing Klebsiella pneumoniae isolated from clinical specimens at Bugando Medical Centre, Tanzania to Piperacillin-Tazobactam

Petro, Daudi; Mushi, Martha F.; Moremi, Nyambura; Iddi, Shabani; Mirambo, Mariam M.; Seni, Jeremiah; Mshana, Stephen E.

doi:10.4314/thrb.v16i1.8

Cited by 2 publications

(1 citation statement)

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“…All these bacteria are normal flora of the gastrointestinal tract and therefore their likelihood of contaminating syrups if hygienic measures are not strict is high. The detection of Pseudomonas aeruginosa in the sampled syrup is a major health concern since this pathogen is often associated with severe infections and resistance to clinically available antimicrobial agents at the study site and other areas [8,[20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Bacterial contamination of syrups in households found in squatter settlements of Mwanza city, Tanzania: A health threat to the community

Karol Julius Marwa,

Norbert Ambrose Haule,

Martha Fidelis Mushi

2023

World J. Bio. Pharm. Health Sci.

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Bacterial contamination of syrups due to improper handling or poor adherence to storage conditions cause spoilage of the products which might lead to serious clinical hazardous problems. Data on the microbiological quality of different syrups at community pharmacy and hospital level is well established. However, there is paucity of data (globally) on microbial contamination of syrups at household level. Therefore, the present study aimed at establishing the magnitude of bacterial contamination in syrups obtained from households and associated factors. About 292 of syrup samples of different types were taken to the microbiology laboratory for analysis as per established protocols. Data were analysed using STATA version 13 following the objectives of the study. A total of 292 syrups were sampled with average of 3.29 syrup type per household. Households found with contaminated syrups were 12 out of 89 (13.5%), whereas the total number of contaminated syrups in these households was 15 (5.1%). The most common bacterial species found as contaminant was Pseudomonas aeruginosa 4 (36.4%) followed by Enterobacter cloacea 2 (18.2%) and Klebsiella pneumoniae 2 (18.2%). A sufficient amount of syrups stored at households were presumably bacteriologically contaminated. The general public needs to be educated on proper handling and storage of liquid pharmaceutical products as a key aspect in eliminating cross-contamination of these products.

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Section: Discussionmentioning

confidence: 99%

Bacterial contamination of syrups in households found in squatter settlements of Mwanza city, Tanzania: A health threat to the community

Karol Julius Marwa,

Norbert Ambrose Haule,

Martha Fidelis Mushi

2023

World J. Bio. Pharm. Health Sci.

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Global Prevalence of Nosocomial Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis

et al. 2021

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The emergence of nosocomial multidrug-resistant Klebsiella pneumoniae is an escalating public health threat worldwide. The prevalence of nosocomial infections due to K. pneumoniae was recorded up to 10%. In this systematic review and meta-analysis, which were conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis, 1092 articles were screened from four databases of which 47 studies fulfilled the selected criteria. By performing a random-effect model, the pooled prevalence of nosocomial multidrug-resistant K. pneumoniae was estimated at 32.8% (95% CI, 23.6–43.6), with high heterogeneity (I2 98.29%, p-value < 0.001). The estimated prevalence of this pathogen and a few related studies were discussed, raising awareness of the spread of multidrug-resistant K. pneumoniae in the healthcare setting. The emergence of nosocomial multidrug-resistant K. pneumoniae is expected to increase globally in the future, and the best treatments for treating and preventing this pathogen should be acknowledged by healthcare staff.

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In vitro susceptibility of multi-drug resistant Pseudomonas aeruginosa and extended-spectrum β-lactamase–producing Klebsiella pneumoniae isolated from clinical specimens at Bugando Medical Centre, Tanzania to Piperacillin-Tazobactam

Cited by 2 publications

References 8 publications

Bacterial contamination of syrups in households found in squatter settlements of Mwanza city, Tanzania: A health threat to the community

Bacterial contamination of syrups in households found in squatter settlements of Mwanza city, Tanzania: A health threat to the community

Global Prevalence of Nosocomial Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis

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