In vitro synergic efficacy of the combination of Nystatin with the essential oils of Origanum vulgare and Pelargonium graveolens against some Candida species

Rosato, Antonio; Vitali, Cesare; Piarulli, Monica; Mazzotta, Manuela; Argentieri, Maria Pia; Mallamaci, Rosanna

doi:10.1016/j.phymed.2009.02.011

Cited by 66 publications

(27 citation statements)

References 13 publications

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“…The EO of M. alternifolia mainly consisted of terpinen-4-ol (30.3%) and γ-terpinene (16.3%). [225] A similar study was carried out based on the same EOs. The aim of this study was to investigate the potential synergistic effect of these oils in combination with amphotericin B.…”

Section: Candidamentioning

confidence: 99%

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

Lang

Buchbauer

2011

Flavour & Fragrance J

345

209

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The antimicrobial activity of essential oils is discussed in this review taking in account studies which were published in the period of time from 2008 until September 2010. Furthermore, the most important methods to examine the antimicrobial efficiency of essential oils are presented. The studies are divided into the following two groups, namely antibacterial and antifungal active agents depending on the activity of the applied essential oil against the test microorganisms. Various interesting possible applications are revealed such as the use of essential oils instead of synthetic drugs to circumvent the increasing resistance of some pathogens. Moreover, they could not only be used for the therapy of infectious illnesses, but also as preservatives in the food industry. A further possibility is, among others, the application of essential oils in skin products in order to treat or avoid dermal infections. Additionally, the prevalent constituents of the individual antimicrobial active essential oils are elaborated.

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Section: Candidamentioning

confidence: 99%

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

Lang

Buchbauer

2011

Flavour & Fragrance J

345

209

View full text Add to dashboard Cite

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“…A number of studies have focused on the synergistic activity of the EO in combination with antibiotic to minimize the side effects of the antibiotic (Mahboubi & Bidgoli, 2010;Rosato et al, 2009;Tohidpour, Sattari, Omidbaigi, Yadegar, & Nazemi, 2010), while the combinations of EO with other natural antibacterial compounds (e.g., nisin) was used in food to reduce the minimum effective dose of EO (Solomakos, Govaris, Koidis, & Botsoglou, 2008). However, a few studies regarding the synergistic effects of EO combinations to obtain effective antimicrobial activity at sufficiently low concentrations and consequently reduce negative sensory impact were performed (Gutierrez, Barry-Ryan, & Bourke, 2009).…”

Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial effects and mechanism of action of selected plant essential oil combinations against four food-related microorganisms

Liang

Yuan

et al. 2011

Food Research International

520

308

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“…In vitro studies have shown satisfactory results regarding the association between natural products and conventional antimicrobials directed for antifungal therapy [13][14][15]. In a study conducted in India [15], the authors showed that the addition of eugenol and carvacrol to fluconazole have significantly reduced the concentration of the latter, in inhibition of biofilm growth by C. albicans.…”

Section: Discussionmentioning

confidence: 99%

“…Based on that, recent studies had given evidence to antimicrobial compounds extracted from plants, in a form of essential oils, crude extracts, and molecules, such as flavonoids and terpenes [8,11,12]. Recent studies have also focused on the association between natural products and conventional pharmacological agents in order to achieve better efficacy of treatments [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Eugenol and its Association with Nystatin on Candida albicans

Silva

Santos

Cavalcanti

et al. 2017

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the anti-Candida effect of eugenol and its antimicrobial interaction with nystatin. Material and Methods: The antimicrobial potential was assessed by microdilution technique (M27A3 reference method), by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) against C. albicans (ATCC 90028). The possible action of eugenol on the fungal cell wall was evaluated with the assistance of the osmotic protector sorbitol (0.8 M). The antimicrobial interaction with nystatin was assessed through the checkerboard method. All tests were performed in triplicate. Results: All groups showed reductions in PI and GBI values and improvements in oral health knowledge, but IG1 and IG2 showed statistically significant differences in these variables compared to CG. Conclusion: The eugenol has antifungal activity against C. albicans and its mechanism of action is probably not related to damage to the fungal cell wall. Association between eugenol and nystatin was not found to be an advantageous possibility for growth inhibition of C. albican.

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In vitro synergic efficacy of the combination of Nystatin with the essential oils of Origanum vulgare and Pelargonium graveolens against some Candida species

Cited by 66 publications

References 13 publications

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

In vitro antimicrobial effects and mechanism of action of selected plant essential oil combinations against four food-related microorganisms

Antifungal Activity of Eugenol and its Association with Nystatin on Candida albicans

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