In vitro Synthesis of Fœtal and Adult Hæmoglobin by Fœtal Hæmatopoietic Tissues

Control of the Simian Fetal Hemoglobin Switch at the Progenitor Cell Level

“…This has been a matter of controversy. For example, the relative ratios of gamma and beta gene expression are influenced in culture by the state ofmaturity oferythroid precursors (4,5).1 They are also said to be influenced by manipulation ofthe conditions in which erythroid precursors are incubated (6,7). The above findings suggest that commitment to particular non-alpha globin gene expression occurs at a relatively late and morphologically identifiable stage of erythroid differentiation.…”

The Turnover of Hemoglobins A, F, and A2 in the Peripheral Blood of Three Patients With Thalassemia*

“…The data of Breathnach indicate that fetal and adult hemoglobin are synthesized side by side in the bone marrow (28), and there seems to be no special predilection for one or the other to be made in extramedullary sites (29). We can therefore safely assume that the cells making these hemoglobins are all bathed in the same extracellular pool of glycine.…”

The Effect of Methemoglobin Formation in Sickle Cell Disease*

“…Fetal hemoglobin interferes with the sickling process in infants (10) and in hereditary persistence of fetal hemoglobin (31). As yet, no method for increasing the synthesis of F hemoglobin is known, although sensitivity in the ratio between hemoglobin F and hemoglobin A synthesized to oxygen tension has been demonstrated (32,33). The alteration of this ratio is due, however, to the fact that while both hemoglobin F and hemoglobin A synthesis is inhibited by anoxia, the degree of inhibition is greater in the case of hemoglobin A.…”