Seaweed polyphenols and polysaccharide plays a broad range of biological activity. The objective of the present study was to study and compare the skin protection activity of fucoidan rich polysaccharide extract (SPS) and polyphenol-rich extract (SPP) from the seaweed Sargassum vachellianum. The skin protection activity was analyzed based on their ability to scavenge free radicals such as hydrogen peroxide and hydroxyl radicals, UV absorption potential, tyrosinase inhibition, moisture preservation, and antibacterial activity. From the results, both SPP and SPS protects the skin from UV damage. SPP showed good free radical scavenging ability, antimicrobial activity against E.coli and S. aureus and effectively absorbed the UVB and UVA rays whereas SPS hardly absorbs the UVA and UVB rays and showed weak free radical scavenging ability and no antimicrobial activity. SPS showed considerable inhibition on tyrosinase (51.21%) and had better moisture absorption (52.1%) and retention (63.24%) abilities than SPP. The results specified that both SPS and SPP have balancing potential on skin protection and suitable combinations of both could act as an active ingredient in cosmetics.calculating skin-lightening activity. In addition, Melanogenesis is described to result in the generation of free radicals like hydrogen peroxide in the melanocytes which again result in oxidative stress. Therefore ROS plays a significant role in the regulation of melanin synthesis and so ROS scavengers help in reduce the UV-induced melanogenesis [5]. Hyperpigmentation can be reduced by free radical scavengers and tyrosinase inhibitors that suppress melanogenesis in the skin [6]. Moisture absorption and retention capacity of the skin is getting disturbed due to age factor and exposure to environmental stress. Once the moisture in the skin is reduced, then the skin will become dry with wrinkles which also results in premature aging. Retaining moisture in the skin is also another important function of the skincare products. Compound that is rich in antioxidant activity associated with anti-tyrosinase and moisture-preserving properties and also has the ability to block the UV rays plays an important role in skin whitening and sunscreen products.Many synthetic chemicals like arbutin, hydroquinone and kojic acid are being used as tyrosinase inhibitors in skin whitening product, but it was testified to side effect like dermatitis, genotoxicity and also induce cancer. Hence, the exploration of an effective skin care agent is still continuing in cosmetic research. In recent years, natural products have become more attractive in the cosmetic industry due to no side effects. The sea harbors a natural compound that is promising to act as biologically active metabolites. Marine algae are highly studied for their potent antioxidant capability [7,8,9,10]. The seaweed bioactive compound can play a vital role in skincare formulation because of its antioxidant properties. The active compound protects the skin in several ways, which includes scavenging the ROS, supp...