In vitro testing of an intra-ventricular assist device

Abstract

A novel pulsatile assist device, intra-ventricular assist device, was proposed to address various disadvantages existing in conventional pulsatile assist device, such as the large size, accessories and reduced pulsatility. The assist device was designed, fabricated and implanted into the sac from left ventricular apex in a home-designed mock circulatory system. In vitro test was carried out and results demonstrated that the response time did not vary with the heart rate, and co-pulsatiled synchronously with native heart by electrocardiograph. The key parameter, stroke volume of proposed device was precisely measured under different afterloads (60, 80, 100, and 120 mmHg), drive pressure (from 90 to 300 mmHg at 30 mmHg intervals), and heart rate (45-150 beats per minute). The measurement results revealed that the output characteristics of device, stroke volume increased with increasing drive pressure but decreased with increasing peripheral resistance, were consistent with the native heart. The proposed pump was then coupled with mock system that was set to a heart failure mode and the circulatory responses were tested. Results showed that the device improved left ventricular pressure from 106 to 158 mmHg, and stroke volume from 25.5 to 44 ml at 90 bpm.

Ventricular Flow Dynamics with an Intra-Ventricular Balloon Pump: An In Vitro Analysis

“…However, IABPs are seeing a reduction in use due to ambiguous improvement in patient mortality and morbidity, whereas patients implanted with the Impella may experience stroke, bleeding, haemolysis and thrombotic events. [3][4][5] Intra-Ventricular Balloon Pumps (IVBPs) are currently investigated in vitro as an alternative treatment strategy to rotary VADs and IABPs, [6][7][8][9][10][11][12][13][14] to provide short-term mechanical circulatory support, which aims to be more cost-effective and lessinvasive than VADs while providing increased hemodynamic energy to the circulation compared to IABP. 13 Early in vivo studies of IVBPs found the device could increase mean arterial pressure (MAP) by 130 mmHg and reduce left atrial end-diastolic pressure up to 15 mmHg below the baseline.…”

“…Intra-Ventricular Balloon Pumps (IVBPs) are currently investigated in vitro as an alternative treatment strategy to rotary VADs and IABPs, 6–14 to provide short-term mechanical circulatory support, which aims to be more cost-effective and lessinvasive than VADs while providing increased hemodynamic energy to the circulation compared to IABP. 13 Early in vivo studies of IVBPs found the device could increase mean arterial pressure (MAP) by 130 mmHg and reduce left atrial end-diastolic pressure up to 15 mmHg below the baseline.…”

“…6,7 Recent in vitro studies confirm that the increase in MAP and cardiac output (CO) are comparable to rotary VADs. 11–14 However, despite evidence of induced mitral regurgitation from IVBP use previously besetting this technology, 7,8,10 it is anticipated that an anatomically fitted balloon could avoid interacting with the mitral valve apparatus, preventing valve prolapse from occurring. 13…”

Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator

“…MCLs are considered beneficial since they can reduce the need for in-vivo studies [16]. MCLs consist of compliance chambers, resistance valves, artificial heart valves or flip valves, and a cardiac simulator [17].…”

Investigação do escoamento no dispositivo de assistência ventricular pediátrico do Incor por velocimetria de imagem de partículas resolvida no tempo.

“…Nesta seção estão os detalhes relacionados ao desenvolvimento do experimento e da técnica de medição utilizada. O EDD foi pensando para prolongar a durabilidade do dispositivo e do sistema, acomodando a inércia entre as câmaras sanguínea e pneumática no momento do sinal elétrico (ZHU et al, 2019). O mesmo raciocínio é válido para o atraso sistólico final.…”