2016
DOI: 10.3390/ma9040276
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In Vitro Testing of Scaffolds for Mesenchymal Stem Cell-Based Meniscus Tissue Engineering—Introducing a New Biocompatibility Scoring System

Abstract: A combination of mesenchymal stem cells (MSCs) and scaffolds seems to be a promising approach for meniscus repair. To facilitate the search for an appropriate scaffold material a reliable and objective in vitro testing system is essential. This paper introduces a new scoring for this purpose and analyzes a hyaluronic acid (HA) gelatin composite scaffold and a polyurethane scaffold in combination with MSCs for tissue engineering of meniscus. The pore quality and interconnectivity of pores of a HA gelatin compos… Show more

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Cited by 13 publications
(15 citation statements)
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“…The loading process of the scaffolds was achieved using a rotary valve vacuum pump (Vacuubrand GmbH, Wertheim, Germany) as already described by Achatz et al [ 44 ].…”
Section: Methodsmentioning
confidence: 99%
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“…The loading process of the scaffolds was achieved using a rotary valve vacuum pump (Vacuubrand GmbH, Wertheim, Germany) as already described by Achatz et al [ 44 ].…”
Section: Methodsmentioning
confidence: 99%
“…Overall, two blinded scorers, both experienced in the knee anatomy of rabbits and in histological assessment, analyzed the sections according to the established scoring system. [ 13 ]…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The scaffold surface can generate cellular responses which can affect adhesion, proliferation, migration, biointegration, and cellular function ( Abbott & Kaplan, 2016 ). This interaction is especially important to define the degree of rejection of medical implants ( Achatz et al, 2016 ).…”
Section: Introductionmentioning
confidence: 99%
“…Many studies have used the bacterial cell membrane in vitro , in preclinical studies investigating drug, hormone, and protein release systems, artificial skin ( Fu, Zhang & Yang, 2013 ), cartilage ( Cruz et al, 2016 ), menisci ( Achatz et al, 2016 ), intervertebral discs ( Fávaro et al., 2016 ), valvular prostheses, artificial corneas, and the urethra ( Rajwade, Paknikar & Kumbhar, 2015 ). However, it will be necessary to improve our knowledge of bacterial cellulose membrane (BCM) biointegration and biodegradation, especially with respect to BM-MSCs.…”
Section: Introductionmentioning
confidence: 99%