In vitro toxicity evaluation of graphene oxide on A549 cells

Chang, Ya-Wen; Yang, Shengnan; Liu, Jiahui; Dong, Erya; Wang, Yanwen; Cao, Aoneng; Liu, Yuanfang; Wang, Haifang

doi:10.1016/j.toxlet.2010.11.016

Cited by 1,183 publications

(892 citation statements)

References 59 publications

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“…4,5 Biopolymer surface-functionalized GO nanosheets were reported to be biocompatible and non-toxic at low concentrations. 6,7 GO has recently been applied to prepare polymer nanocomposite hydrogels with improved mechanical performance compared to conventional hydrogels, 8,9 and various self-assembly approaches were used to prepare physically cross-linked GO-polymer nanocomposite hydrogels. 10,11 The driving forces to form these hydrogels were physical interactions including π-π interaction, hydrogen bonding, electrostatic interaction and coordination.…”

Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

Piao

Chen

2016

Ind. Eng. Chem. Res.

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Graphene oxide (GO)-polyamidoamine (PAMAM) dendrimer nanocomposite hydrogels were prepared through one-step synthesis by mixing a GO suspension and a PAMAM solution at varying ratio of GO to PAMAM. The materials self-assembled into physically crosslinked networks, mainly driven by electrostatic interactions between the oppositely charged GO nanosheets and PAMAM dendrimer. The chemical structure of PAMAM dendrimer was studied by mass spectrometry, nuclear magnetic resonance spectroscopy and potentiometric titration.The structure and properties of GO-PAMAM nanocomposite hydrogels were investigated by Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffraction, scanning electron microscopy and rheometry. The nanocomposite hydrogels exhibited a relatively high mechanical performance with a storage modulus of up to 284 kPa, as well as self-healing property, owing to their reversible and multiple physical cross-links. These hydrogels may be further developed for biomedical applications.2

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Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

Piao

Chen

2016

Ind. Eng. Chem. Res.

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“…These studies have shown the use of graphene in microbial fuel cells, 249 graphene as a scaffold for bacterial growth, 228 as well as the use of bacteria as a graphene oxide reducing agent. 250,251 Various in vitro toxicity studies have been conducted to determine the toxicity of graphene towards cancer [234][235][236][237][238] and human cell lines. 229,239 The cytotoxicity towards the cancer cell lines A549 was shown to depend largely on the cell culture medium components.…”

Section: Environmental and Biological Toxicity Of Graphenementioning

confidence: 99%

“…229,239 The cytotoxicity towards the cancer cell lines A549 was shown to depend largely on the cell culture medium components. 234,235 In particular it was noted that fetal bovine serum played a very important role, as it seems to coat the graphene sheets making them less toxic towards cell lines. 235 In a study by Gollavelli and Ling, the effect of graphene oxide and polyacrylic acid, uorescein o-methacrylate functionalized graphene oxide, on HeLa cells was determined.…”

Section: Environmental and Biological Toxicity Of Graphenementioning

confidence: 99%

Environmental applications using graphene composites: water remediation and gas adsorption

et al. 2013

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This review deals with wide-ranging environmental studies of graphene-based materials on the adsorption of hazardous materials and photocatalytic degradation of pollutants for water remediation and the physisorption, chemisorption, reactive adsorption, and separation for gas storage. The environmental and biological toxicity of graphene, which is an important issue if graphene composites are to be applied in environmental remediation, is also addressed.

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“…Their results suggest that GO can not enter A549 cells and has no obvious toxicity. However, GO can cause a loss of cell viability at high concentration [35].…”

Section: Toxicity Of Graphene and Graphene Oxidementioning

confidence: 99%

Biological Applications of Graphene and Graphene Oxide

Wu¹,

Zhang²,

Wu³

et al. 2012

Nano BioMed ENG

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Graphene, as a steady two dimensional (2D) carbon material, possesses intriguing physical and chemical properties, which arouses great interests of scientists for its applications in enormous fields. In particular, graphene and graphene oxide have been widely used for drug delivery and DNA detection based on π-π stacking and hydrophobic interactions. Besides, graphene with fluorescent molecules or nanoparticles and graphene quantum dots have also been frequently applied as fluorescent probe. In this article, advances of graphene and graphene oxide on biomedical applications will be highlighted from the perspective of biomolecular interaction, cell imaging, drug delivery, and toxicity.

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In vitro toxicity evaluation of graphene oxide on A549 cells

Cited by 1,183 publications

References 59 publications

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

Environmental applications using graphene composites: water remediation and gas adsorption

Biological Applications of Graphene and Graphene Oxide

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