In-vitro toxicity induced by quartz nanoparticles: Role of ER stress

Sushma, .; Kumar, Hridyesh; Ahmad, Iqbal; Dutta, Pradip Kumar

doi:10.1016/j.tox.2018.05.001

Cited by 9 publications

(4 citation statements)

References 49 publications

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“…Therefore, toxicity could be intensified by a decrease in particle size, from micro to nanoscale. This has improved the foundation of amplified superficial total atoms, as reported by Kumar et al [63]. In the present study, high-spatial-resolution methodology, using AEMs as the principal investigations for both chemistry and assembly, were applied to examine ultrafine particles and NPs containing PHEs.…”

Section: Discussionmentioning

confidence: 84%

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Environmental Impacts of Coal Nanoparticles from Rehabilitated Mine Areas in Colombia

et al. 2022

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With the possible increase in mining activities and recently projected population growth in Colombia, large quantities of nanoparticles (NPs) and potentially hazardous elements (PHEs) will be of major concern to mine workers, indigenous residents, and surrounding communities. This study highlights the need to regulate the pollution from Colombian mining activities that comply with regional regulations and global strategies. Colombian coal rejects (CRs) from the Cesar Basin, Colombia, were studied primarily by advanced electron microscopic and analytical procedures. Therefore, the goal of this research is to evaluate the role of NPs in the alteration of CRs’ structure in a renewed zone at Cerrejón coal area (La Guajira, Colombia) through advanced electron microscopic (AEMs) methods. The objective of the analysis is to evaluate the incidence mode of nanoparticles, which contain potentially hazardous elements. The bulk crystallography (X-ray diffraction), chemical structure, and morphologies of NPs were studied by high-resolution transmission electron microscopy (HR-TEM), field emission scanning electron microscopy (FE-SEM), micro-beam diffraction (MBD), selected area electron diffraction (SAED), and energy-dispersive X-ray spectroscopy (EDX) procedures. The AEMs provided comprehensive insights into the geochemical evolution of CRs. Consequently, the AEMs can be used as essential tools for CR management in coal mining areas. The regular dimension of detected NPs was found to be above 2 nm. Ultrafine particles of quartz were identified by the advanced electron microscopy. Furthermore, the findings also revealed aluminium, calcium, potassium, titanium, iron oxides, and PHEs in the CRs. The extensive water practice in the coal extraction process combined with atmospheric oxygen supports oxidations of iron sulphide, thus releasing PHEs to the surrounding environment. Dehydration of sulphate salts fluctuate at consistent humidity in the coal mine environments. The study demonstrates the great influence of coal mining activities on the environment and human health.

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Section: Discussionmentioning

confidence: 84%

“…The nanophases of amorphous minerals are naturally formed by environmental forces [22,23,62,63]. Therefore, toxicity could be intensified by a decrease in particle size, from micro to nanoscale.…”

Section: Discussionmentioning

confidence: 99%

Environmental Impacts of Coal Nanoparticles from Rehabilitated Mine Areas in Colombia

et al. 2022

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“…The impurities include brucite, quartz, cristobalite, calcite, albite, illite, etc., which can cause side effects in humans. For example, quartz enhances the production of reactive oxygen species and results in oxidative damage [ 27 , 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Toxicological Evaluation toward Refined Montmorillonite with Human Colon Associated Cells and Human Skin Associated Cells

Wang,

Jiang,

Tian

et al. 2024

JFB

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Montmorillonite has been refined to overcome uncertainties originating from different sources, which offers opportunities for addressing various health issues, e.g., cosmetics, wound dressings, and antidiarrheal medicines. Herein, three commercial montmorillonite samples were obtained from different sources and labeled M1, M2, and M3 for Ca-montmorillonite, magnesium-enriched Ca-montmorillonite, and silicon-enriched Na-montmorillonite, respectively. Commercial montmorillonite was refined via ultrasonic scission-differential centrifugation and labeled S, M, or L according to the particle sizes (small, medium, or large, respectively). The size distribution decreased from 2000 nm to 250 nm with increasing centrifugation rates from 3000 rpm to 12,000 rpm. Toxicological evaluations with human colon-associated cells and human skin-associated cells indicated that side effects were correlated with excess dosages and silica sand. These side effects were more obvious with human colon-associated cells. The microscopic interactions between micro/nanosized montmorillonite and human colon-associated cells or human skin-associated cells indicated that those interactions were correlated with the size distributions. The interactions of the M1 series with the human cells were attributed to size effects because montmorillonite with a broad size distribution was stored in the M1 series. The M2 series interactions with human cells did not seem to be correlated with size effects because large montmorillonite particles were retained after refining. The M3 series interactions with human cells were attributed to size effects because small montmorillonite particles were retained after refining. This illustrates that toxicological evaluations with refined montmorillonite must be performed in accordance with clinical medical practices.

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“…Previous studies showed that a panel of NPs could induce ER stress leading to activation of caspase-3 as the mechanism for NP-induced toxicity. [36][37][38] Therefore, it is possible that the reduced ER stress levels after co-exposure to ZnO NPs and MY could contribute to the cytoprotective effects of MY. Recently we also found that cyanidin, although showing minimal impact on ZnO NP internalization, protected Caco-2 cells from ZnO NPs through the modulation of autophagy.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of combined exposure of ZnO nanoparticles (NPs) and myricetin to Caco-2 cells: changes of NP colloidal aspects, NP internalization and the apoptosis-endoplasmic reticulum stress pathway

Luo

Liu

et al. 2019

Toxicology Research

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Phytochemicals as typical food components may significantly influence the toxicity of nanoparticles (NPs) in intestinal cells, indicating a need to evaluate the toxicological effects of NPs in a complex situation. Previous studies suggested that the anti-oxidative properties of phytochemicals were important to elicit cytoprotective effects against NP exposure. However, we recently found that the changes of signaling pathways may be more important for cytoprotective effects of phytochemicals. In this study, we investigated the influence of myricetin (MY) on the cytotoxicity of ZnO NPs in Caco-2 cells and the possible mechanism. MY at 50 μM showed minimal impact on the solubility and colloidal aspects of ZnO NPs, but protected Caco-2 cells from NP exposure as it increased the EC50 value. For comparison, dihydromyricetin (DMY; chemical analog of MY) increased the EC50 value to a much lesser extent. Exposure to ZnO NPs significantly induced intracellular Zn ions, whereas MY or DMY did not significantly influence the internalization of NPs. However, ZnO NPs significantly promoted the ratio of caspase-3/pro-caspase-3, which was inhibited by the presence of MY. Exposure to ZnO NPs did not significantly promote the biomarkers of endoplasmic reticulum (ER) stress, but co-exposure to ZnO NPs and MY significantly lowered the levels of a panel of ER stress biomarkers. In conclusion, these results suggested that MY could protect Caco-2 cells from ZnO NP exposure, which may not be related to the changes of colloidal stability or internalization of NPs but could be alternatively related to the reduction of ER stress leading to lower cleaved caspase-3.

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In-vitro toxicity induced by quartz nanoparticles: Role of ER stress

Cited by 9 publications

References 49 publications

Environmental Impacts of Coal Nanoparticles from Rehabilitated Mine Areas in Colombia

Environmental Impacts of Coal Nanoparticles from Rehabilitated Mine Areas in Colombia

Toxicological Evaluation toward Refined Montmorillonite with Human Colon Associated Cells and Human Skin Associated Cells

Toxicity of combined exposure of ZnO nanoparticles (NPs) and myricetin to Caco-2 cells: changes of NP colloidal aspects, NP internalization and the apoptosis-endoplasmic reticulum stress pathway

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