In vitro toxicity of palladium(II) and gold(III) porphyrins and their aqueous metal ion counterparts on Trypanosoma brucei brucei growth

Nyarko, Elvis; Hara, Toshihide; Grab, Dennis J.; Habib, Ahsan; Kim, Yuri; Nikolskaia, Olga V.; Fukuma, Toshihide; Tabata, Masaaki

doi:10.1016/j.cbi.2004.03.004

Cited by 78 publications

(44 citation statements)

References 16 publications

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“…The trypanocidal effects of porphyrins bonded to different metals including gold (III) have been evaluated against T. brucei brucei growth and sodium tetrachloaurate (III) was found to be more toxic to this parasite than the gold (III) porphyrin complex; this result was attributed to free radical generation in the presence of the gold (III) ion [99].…”

Section: Gold Complexes As Potential Anti-trypanosomiasis Agentsmentioning

confidence: 99%

Gold complexes as potential anti-parasitic agents

Navarro

2009

Coordination Chemistry Reviews

215

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Section: Gold Complexes As Potential Anti-trypanosomiasis Agentsmentioning

confidence: 99%

Gold complexes as potential anti-parasitic agents

Navarro

2009

Coordination Chemistry Reviews

215

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“…We have previously reported that gold(III) porphyrin complexes can bind to DNA, 27,28 one of the major targets for other anticancer drugs, 43 and they are stable towards demetallation into free metal ion or the free base porphyrin components. 44 It is therefore likely that [Au(TPP)]Cl disturbs or dys-regulates the antiapoptotic machinery of the tumor cells by binding to DNA in the nucleus and/or mitochondria in its complex form, instead of in the form of free radicals. Moreover, we have also shown that gold(III) porphyrin complexes bind to DNA noncovalently, 28 which is different from that described for cisplatin.…”

Section: Discussionmentioning

confidence: 99%

Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo

Sun

Chen

et al. 2009

Intl Journal of Cancer

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Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threatening. In this report, another metallo-pharmaceutical agent gold(III) porphyrin complex [Au(TPP)]Cl was investigated in comparison to cisplatin for its in vitro and in vivo anticancer effects. Through induction of the intrinsic apoptosis pathway, [Au(TPP)]Cl exhibited 100-fold higher potency than cisplatin in killing NPC cells, including cisplatin-sensitive and cisplatin-resistant variants, and also an variant harboring the Epstein-Barr virus. In addition, a safety concentration window was demonstrated, allowing [Au(TPP)]Cl to kill tumors with minimal cytotoxicity to noncancerous cells. More importantly, weekly intraperitoneal injection of 3 mg/kg [Au(TPP)]Cl was more effective than the same dose of cisplatin in inducing tumor apoptosis in vivo and remarkably inhibited tumor growth in animals without any noticeable side effect. [Au(TPP)]Cl therefore is a promising chemotherapeutic agent that deserves further development as a novel drug for the treatment of advanced NPC, in particular, for cases with cisplatin-resistance.

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“…On the contrary, it is known that Au(III) acts as inert metal due to its d 8 electronic configuration. But very recently, it has been observed that aqueous Au(III) shows higher toxicity to Trypanosoma brucei brucei [19] in the HMI-9 medium (HMI-9 medium contains 0.05 M HEPES to maintain the physiological pH 7.5), while [Au(III)(TMPyP)] 5+ or Pd(II) or its counterpart [Pd(II)(TMPyP)] 4+ shows least toxic effects on T. b. brucei, where H 2 (TMPyP) 4+ refers to tetrakis(1-methylpyridium-4-yl)porphyrin.…”

Section: Introductionmentioning

confidence: 99%