In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule

Esboei, Bahman Rahimi; Fakhar, Mahdi; Chabra, Aroona; Hosseini, Mahboobeh

doi:10.1016/s2221-1691(13)60160-4

Cited by 18 publications

(16 citation statements)

References 25 publications

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“…[ 29 ] Furthermore, it has been shown that commercial chitosan with the highest degree of deacetylation has high scolicidal activity in vitro . [ 30 ] Scolicidal activity of Endophytic pestalotiopsis has also been shown. There may be some bioactive compounds on it that have a selective action on the tegument layer of protoscoleces.…”

Section: Different Agents With Scolicidal Activitiesmentioning

confidence: 99%

Scolicidal agents for protoscolices of Echinococcus granulosus hydatid cyst: Review of literature

et al. 2017

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Hydatid cyst is the larval stage of dog tape worm Echinococcus granulosus. Protoscolices are parasite larvae that develop into adult worms in the final host intestine. During surgical treatment of human hydatidsosis spillage of live protoscolices is the major cause of hydatidosis recurrence. To prevent this problem scolicidal agent such as hypertonic salt are used to kill the protoscolices that may disseminate into the patient's tissues during surgery. However, they may have some unacceptable side effects. To find scolicidal agents with high efficacy, the effect of different compounds on protoscolices of hydatid cyst in vitro has been reviewed. Using PubMed, Scopus, Google Scholar, and SID databases articles about scolicidal effects of different agents on protoscolices of hydatid cyst in vitro were collected. Foeniculum vulgare after 5 min, metalonic extracts of Allium sativum and hypertonic saline after 10 min, and warm water after 2 min kill all alive protoscolices. The above agents that in minimum time and minimum concentration have 100% scolicidal activity, could be good candidates for further investigations.

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Section: Different Agents With Scolicidal Activitiesmentioning

confidence: 99%

Scolicidal agents for protoscolices of Echinococcus granulosus hydatid cyst: Review of literature

et al. 2017

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“…The scolicidal tests were done three times (triplicate) and based on Rahimi-Esboei et al (2013). In the current study, four concentrations (1, 10, 50 and 100 mg/ml) of extracts were examined for 5, 10, 30, 60 and 180 min.…”

Section: Scolicidal Testsmentioning

confidence: 99%

Insignificant activity of Allium paradoxium and Tanacetum parthenium on protoscoleces of Echinococcus granulosus: In vitro study

Raeisi¹,

Esboei²

2016

J. Med. Plants Res.

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Medicinal plants are now recognized as most important alternative for chemical drugs resource, especially for anti-microbial targets. The current study aimed to determine the scolicidal effect of Allium paradoxium and Tanacetum parthenium as medicinal plants in vitro. Protoscoleces were exposed to different concentrations of chloroformic and hydroalcholic extracts (1, 10, 50 and 100 mg/mL) for 5, 10, 30, 60 and 120 min. Viability of protoscolices was confirmed by 0.1% Eosin staining. The results of this study showed that all extracts used were not significantly effective in comparison with the control group. Therefore, chloroformic and hydroalcholic extracts of A. paradoxium and T. parthenium could not be used during hydatid cyst treatment. However, there remains the need to perform advanced comparative clinical studies on the efficacy of A. paradoxium and T. parthenium and other scolicidal agents. Chloroformic and hydroalcoholic extract of A. paradoxium and T. parthenium, did not show any scolicidal activity at the concentration of 1, 10, 50 and 100 mg/ml.

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“…[ 196 ], Mallotus philippinensis [ 199 ], Sambucus ebulus [ 200 ], Trametes robiniophila murr [ 101 ], Berberis vulgaris [ 201 ], Pestalotiopsis spp. [ 202 ], Satureja khuzestanica and Olea europaea [ 203 ], Salvadora persica [ 204 ], Zingiber officinale [ 205 , 206 ], Curcuma longa [ 206 ], Nigella sativa [ 207 , 208 ], Pistacia atlantica [ 209 ], Cnidium monnieri [ 210 ], Punica granatum [ 211 ], and Penicillium [ 212 – 214 ]. All of them showed ≥90% scolicidal activity with the exception of the hydroalcoholic extracts of Corylus spp.…”

Section: Introductionmentioning

confidence: 99%

“…showed also to be fully effective against E . granulosus protoscoleces in vitro , although at prolonged (≥30 min) incubation times [ 202 , 212 – 214 ], thus their usefulness as scolicidal agents in intra-cyst application in limited. The third extract derived from a fungus ( Trametes robiniophila ) showed little effectivity against protoscoleces.…”

Section: Introductionmentioning

confidence: 99%

Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets

et al. 2018

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Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans. To compensate this therapeutic shortfall, new treatment alternatives are urgently needed, including the identification, development, and assessment of novel compound classes and drug targets. Here is presented a thorough overview of the range of compounds that have been tested against E. granulosus and E. multilocularis in recent years, including in vitro and in vivo data on their mode of action, dosage, administration regimen, therapeutic outcomes, and associated clinical symptoms. Drugs covered included albendazole, mebendazole, and other members of the benzimidazole family and their derivatives, including improved formulations and combined therapies with other biocidal agents. Chemically synthetized molecules previously known to be effective against other infectious and non-infectious conditions such as anti-virals, antibiotics, anti-parasites, anti-mycotics, and anti-neoplastics are addressed. In view of their increasing relevance, natural occurring compounds derived from plant and fungal extracts are also discussed. Special attention has been paid to the recent application of genomic science on drug discovery and clinical medicine, particularly through the identification of small inhibitor molecules tackling key metabolic enzymes or signalling pathways.

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In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule

Cited by 18 publications

References 25 publications

Scolicidal agents for protoscolices of Echinococcus granulosus hydatid cyst: Review of literature

Scolicidal agents for protoscolices of Echinococcus granulosus hydatid cyst: Review of literature

Insignificant activity of Allium paradoxium and Tanacetum parthenium on protoscoleces of Echinococcus granulosus: In vitro study

Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets

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