In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Abstract

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity

Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE)

“…The trypanocidal properties of the major components of the essential oil from green fruits P. ovatum, β-myrcene (62.0 %), α-pinene (11.3 %) and limonene (7.3 %) were previously reported (SANTOS et al 2014;SARTORELLI et al 2012;ZENG et al 2010). It was proposed that the activity of essential oils against trypanosomatids is mainly due to its terpene composition.…”

In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)

“…The compound α-pinene (1.2 %), which is also found in the essential oil from Schinus terebinthifolius, has recognised trypanocidal activity (Sartorelli et al 2012). Other notable compounds identified in the essential oil from P. ovatum leaves have already had their antiparasitic activity reported by the literature are: myrcene (8.4 %), sabinene (1.8 %), terpinen-4-ol (0.4 %) and β-pinene (2.1 %) (Silva et al 2015b).…”

Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae)

“…10 Os óleos essenciais de folhas, flores e frutos de S. terebinthifolius de diferentes regiões foram previamente analisados, os quais se mostraram compostos basicamente por derivados mono e sesquiterpênicos. 11 No que se refere à avaliação da atividade biológica, os óleos voláteis dos frutos foram analisados e apresentaram atividade alelopática, 12 citotóxica 13 e tripanocida, 14 enquanto que o óleo das folhas mostrou atividade citotóxica. 15 Como parte de nossos estudos visando o reconhecimento de compostos com ação citotóxica em espécies vegetais brasileiras, neste trabalho foi realizado o estudo fitoquímico do extrato etanólico das folhas de S. terebinthifolius, o qual apresentou potencial in vitro frente a células tumorais humanas de melanoma (A2058), adenocarcinoma de mama (MCF7), leucemia (HL-60) e carcinoma cervical (HeLa).…”