In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

Tong, Fei; Chai, Rongkui; Jiang, Haiying; Dong, Bin

doi:10.2147/ijn.s153763

Cited by 28 publications

(18 citation statements)

References 49 publications

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“…Curcumin-ZnO (10 mg/kg, for 21 days) nanoparticles were claimed to be more effective than curcumin nanoparticles (50 mg/kg, for 21 days) in diabetes therapy in terms of reduction of blood glucose, improvement in serum insulin, and activation of GLUT2 and glucokinase genes in pancreas and liver of type 2 diabetic rats [191]. Nanocarrier constituted with poly-(γ-benzyl l-glutamate), poly-(ethylene glycol), and poly-(γ-benzyl 1-glutamate) has been shown to improve the bioactivity and water solubility of curcumin [192]. The design of this nanocarrier offered high loading capacity, gradual release, and low cytotoxicity [192].…”

Section: Curcuminmentioning

confidence: 99%

“…Nanocarrier constituted with poly-(γ-benzyl l-glutamate), poly-(ethylene glycol), and poly-(γ-benzyl 1-glutamate) has been shown to improve the bioactivity and water solubility of curcumin [192]. The design of this nanocarrier offered high loading capacity, gradual release, and low cytotoxicity [192]. Curcumin-encapsulated multi-polymeric nanocarrier achieved better pharmacological effects in cross-regulation of Ca 2+ /calmodulin, calcium-sensing receptor gene and endogenous cystathionine γ-lyase/H 2 S over conventional curcumin formulations in the management of diabetic cardiomyopathy in rats [192].…”

Section: Curcuminmentioning

confidence: 99%

“…The design of this nanocarrier offered high loading capacity, gradual release, and low cytotoxicity [192]. Curcumin-encapsulated multi-polymeric nanocarrier achieved better pharmacological effects in cross-regulation of Ca 2+ /calmodulin, calcium-sensing receptor gene and endogenous cystathionine γ-lyase/H 2 S over conventional curcumin formulations in the management of diabetic cardiomyopathy in rats [192]. Curcumin-encapsulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles were found to be effective in enhancing the relative oral bioavailability (5.6-fold to native curcumin) and improving biological half-life of curcumin via improving water solubility, triggering drug release in the intestinal juice, enhancing permeation, inhibiting P-gp efflux, and increasing residence time in the intestinal cavity [193].…”

Section: Curcuminmentioning

confidence: 99%

“…Fabrication of nanocarriers can offer better drug loading capacity, gradual release, low toxicity, and antidiabetic efficacy of the formulations [192]. Development of different block polymers such as nanocarriers using PLGA, PEG, PCL, poly(ε-caprolactone), polyacrylamide, chitosan, pluronic etc.…”

Section: Interpretation and Conclusionmentioning

confidence: 99%

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Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Curcuminmentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Section: Interpretation and Conclusionmentioning

confidence: 99%

See 2 more Smart Citations

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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“…Comparison of the effect of the nanoencapsulated polyphenol was done with the polyphenol-void nanocarrier, other bioactives/pharmaceuticals, and also with its free-form. The biological effects and conditions assessed included anti-diabetic and antioxidant activity [63,97,98], diabetic neuropathic pain [99,100], diabetic cardiomyopathy [101,102], inflammation [103][104][105], and cataract in a diabetic rat model [106]. It was reported that nanoencapsulated curcumin produced anti-diabetic effects by increasing the number of insulin positive cells and the gene expression of insulin, alleviating STZ-induced β-cell damage and increasing the upregulation of the transcription factors pancreatic and duodenal homeobox 1 (Pdx-1), which play a critical role in pancreatic development, and NKx6.1 which is required for the development of β-cells [97,98].…”

Section: Diarylheptanoidmentioning

confidence: 99%

Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

Rambaran

2020

SN Appl. Sci.

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Polyphenols are believed to possess numerous health benefits and can be grouped as phenolic acids, flavonoids or non-flavonoids. Research involving the synthesis of nanopolyphenols has attracted interest in the areas of functional food, nutraceutical and pharmaceutical development. This is in an effort to overcome current challenges which limit the application of polyphenols such as their rapid elimination, low water-solubility, instability at low pH, and their particle size. In the synthesis of nanopolyphenols, the type of nanocarrier used, the nanoencapsulation technique employed and the type of polymers that constitute the drug delivery system are crucial. For this review, all mentioned factors which can influence the therapeutic efficacy of nanopolyphenols were assessed. Their efficacy as anti-diabetic agents was also evaluated in 33 publications. Among these were phenolic acid (1), flavonoids (13), non-flavonoids (17) and polyphenolrich extracts (2). The most researched polyphenols were quercetin and curcumin. Nanoparticles were the main nanocarrier and the size of the nanopolyphenols ranged from 15 to 333 nm with encapsulation efficiency and drug loading capacities of 56-97.7% and 4.2-53.2%, respectively. The quantity of nanomaterial administered orally ranged from 1 to 300 mg/kg/day with study durations of 1-70 days. Most studies compared the effect of the nanopolyphenol to its freeform and, in all but three cases, significantly greater effects of the former were reported. Assessment of the polyphenol to understand its properties and the subsequent synthesis of its nanoencapsulated form using suitable nanocarriers, polymers and encapsulation techniques can result in effective therapeutic agents for the treatment of diabetes.

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Advances in Nanoencapsulated Phytomedicines (Phytochemicals and Their Extracts) for the Treatment of Obesity, Diabetes, and Their Associated Complications

Dinda

Dinda²

2022

Natural Products in Obesity and Diabetes

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In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

Cited by 28 publications

References 49 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

Advances in Nanoencapsulated Phytomedicines (Phytochemicals and Their Extracts) for the Treatment of Obesity, Diabetes, and Their Associated Complications

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