In Vitro vs in Vivo Corrosion Analyses of Two Alloys

Lucas, L. C.; Dale, Paul; Buchanan, R.A.; Gill, Y.; Griffin, Drees; Lemons, Jack E.

doi:10.3109/08941939109140757

Cited by 20 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrochemical corrosion techniques have been used to show that nickel-chromium alloys do corrode in physiological solutions such as balanced salt, proteinaceous, artificial saliva, human saliva, and artificial sweat solutions (Lee et al, 1985;Lucas et al, 1991;Randin, 1988;Johansson et al, 1989a;Cow'mgionetal, 1985). Specifically, some of the nickel-based alloys have been shown to be susceptible to pitting and/or crevice corrosion phenomena.…”

Section: Noble and Semi-noble Alloysmentioning

confidence: 99%

Biodegradation of Restorative Metallic Systems

Lucas¹,

Lemons

1992

Adv Dent Res.

View full text Add to dashboard Cite

Metallic materials utilized for the construction of intra-oral and implant dental restorations include a wide range of relatively pure metals and multicomponent alloys. Basic corrosion and biodegradation properties of these alloys have been studied by both in vitro and in vivo techniques. These property characteristics have been shown to be dependent on composition and metallurgical state, combinations within a construct, surface conditions, mechanical aspects of function, and the local and systemic host environment. The susceptibility of these metallic materials to various forms of biodegradation will be presented, with emphasis on corrosion.

show abstract

Section: Noble and Semi-noble Alloysmentioning

confidence: 99%

Biodegradation of Restorative Metallic Systems

Lucas¹,

Lemons

1992

Adv Dent Res.

View full text Add to dashboard Cite

show abstract

“…Corrosion studies have shown that nickel-chromium alloys have relatively low breakdown potentials and are susceptible to pitting and crevice corrosion (Lee et al, 1985;Johansson et al, 1989;Lucas et al, 1991;Bumgardner and Lucas, 1993a). Consequently, concerns remain over the potential release of increased levels of metal ions such as nickel, chromium, and beryllium and the development of metal sensitivity, carcinogenicity and/or toxicity.…”

Section: Introductionmentioning

confidence: 97%

Cellular Response to Metallic Ions Released from Nickel-Chromium Dental Alloys

1995

View full text Add to dashboard Cite

Concerns exist over the potential release of elevated levels of metal ions such as Ni and Be from Ni-Cr dental casting alloys, due to their susceptibility to accelerated corrosion. In this investigation, we evaluated the release of metal ions from four commercial Ni-Cr alloys, representing a range of compositions, in three-day cell culture tests. Metal ion release, as measured by atomic absorption spectroscopy, was correlated to changes in cellular morphology, viability, and proliferation. The results showed that the test alloys and their corrosion products did not affect cellular morphology or viabilities, but did decrease cellular proliferation. The types and amounts of metal ions released, which corresponded to the alloys' reported surface and corrosion properties, also correlated to observed decreases in cellular proliferation after 72 h. Neptune, which caused the smallest decrease in cellular proliferation as compared with control cells, released the lowest amount of corrosion products, due to its corrosion-resistant, high-Cr-Mo-containing, homogeneous surface oxide. The other test alloys, which were susceptible to accelerated corrosion processes, released higher levels of metal ions that correlated to larger decreases in thymidine incorporation. Metal ion levels increased with test time for all alloys but were not proportional to bulk alloy compositions. Ni ions were released at slightly higher than bulk alloy compositions, while Be was released at from four to six times that of bulk alloy compositions. The elevated release of Be ions was associated with reduced cellular proliferation.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…Protein adsorption alters corrosion depending on pH, the type of alloy, surface condition of the alloy, the presence of other metal ions, and the nature of protein adsorption onto the alloy 21–28. Other studies have assessed the effects of hydrogen peroxide,29–31 proteins,22‐24, 26, 28, 32 mechanical stress,33–36 wear/fretting,37, 38 and cells31, 33, 34, 39‐42 on implant material corrosion properties and have used animal models to correlate metal ions release to in vitro corrosion testing 43, 44. However, these studies generally have been restricted to the use of flat or cylindrical “bulk” samples in commercial electrolytes (i.e., saline, serum, or artificial saliva) 19, 38, 42, 45–50.…”

Section: Introductionmentioning

confidence: 99%

Corrosion of machined titanium dental implants under inflammatory conditions

et al. 2008

View full text Add to dashboard Cite

The effects of hyperglycemia, altered cell function, or inflammatory mediators on implant corrosion are not well studied; yet, these effects are critical to implant biocompatibility and osseointegration. Because implant placement is burgeoning, patients with medically compromising systemic conditions such as diabetes are increasingly receiving implants, and the role of other inflammatory diseases on implant corrosion also needs investigation. In the current study, the corrosion properties of commercially available, machined titanium implants were studied in blood, cultures of monocytic cells, and solutions containing elevated dextrose concentrations. Implant corrosion was estimated by open circuit potentials, linear polarization resistance, and electrical impedance spectroscopy (EIS) for 26 h. In selected samples, THP1 monocytic cells were activated for 2 h with Lipopolysaccharide prior to implant exposure, and IL-1beta secretion was measured to assess the affect of the implants on monocyte activation. Implants under conditions of inflammatory stress exhibited more negative E(corr) values, suggesting an increased potential for corrosion. Linear polarization measurements detected increased corrosion rates in the presence of elevated dextrose conditions over PBS conditions. EIS measurements suggested that implants underwent surface passivation reactions that may have limited corrosion over the short term of this test. This result was supported by cyclic polarization tests. IL-1beta secretion was not altered under conditions of corrosion or implant exposure. The results suggest that inflammatory stress and hyperglycemia may increase the corrosion of dental endosseous titanium-based implants, but that longer, more aggressive electrochemical conditions may be necessary to fully assess these effects.

show abstract

In Vitro vs in Vivo Corrosion Analyses of Two Alloys

Cited by 20 publications

References 8 publications

Biodegradation of Restorative Metallic Systems

Biodegradation of Restorative Metallic Systems

Cellular Response to Metallic Ions Released from Nickel-Chromium Dental Alloys

Corrosion of machined titanium dental implants under inflammatory conditions

Contact Info

Product

Resources

About