In vitro Wound Healing Potential and Antimicrobial Activity of Clerodendrum Inerme Leave Extracts

Wisessombat, Sueptrakool; Tayeh, Malatee

doi:10.5530/pj.2021.13.196

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…However, the extraction of highly polar compounds with water can generate extracts with greater antibacterial activity against E. coli in comparison with S. aureus . Thus, due to the permeability of the walls, Gram-negative bacteria are usually less susceptible to antibacterial agents than Gram-positive bacteria [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review

et al. 2022

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Dressings made with polyurethanes have been found to exhibit good and varied biological properties that make them good candidates for this application. However, as has been seen, the wound-healing process is complex, which includes four different stages. So far, the design and evaluation of polyurethane for wound dressing has focused on achieving good properties (mechanical, physicochemical, and biological), but each of them separates from the others or even directed at only one of the stages of skin wound-healing. Therefore, the aim of this systematic review is to explore the applications of polyurethanes in wound dressings and to determine whether could be designed to cover more than one stage of skin wound-healing. The PRISMA guidelines were followed. The current research in this field does not consider each stage separately, and the design of polyurethane dressings is focused on covering all the stages of wound healing with a single material but is necessary to replace polyurethanes in short periods of time. Additionally, little emphasis is placed on the hemostasis stage and further characterization of polyurethanes is still needed to correlate mechanical and physicochemical properties with biological properties at each stage of the wound-healing. Current research demonstrates an effort to characterize the materials physiochemically and mechanically, but in terms of their biological properties, most of the literature is based on the performance of histological tests of explants morphologically probing the compromised tissues, which give an indication of the potential use of polyurethanes in the generation of wound-healing dressings.

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Section: Discussionmentioning

confidence: 99%

Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review

et al. 2022

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“…Revered for its anti-inflammatory, hepatoprotective, analgesic, antipyretic, antioxidant, antimicrobial, and antidiabetic properties, C.inerme is extensively utilized. [10][11][12][13][14] Our objective was to investigate the impact of fractionated components from Clerodendrum inerme on AAG allied with AD.…”

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confidence: 99%

Anti-Angiogenic Effect of Clerodendreme inerme Leaves Extract

Kotagiri,

Kumar

2023

IJPQA

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Clerodendrum inerme, a medicinal plant, exhibits diverse pharmacological properties. Various species within the Clerodendrum genus have been traditionally utilized in indigenous medical systems and folk remedies. This study intended to scrutinize the anti-angiogenic possibility of CI through in-ovo, in-vitro, and in-vivo approaches. The screening methods employed include the chick chorioallantoic membrane test (in-ovo), sponge bud technique (in-vivo), as well as in-vitro assays for cell migration, cell proliferation, along with morphogenesis. Statistical analyses involved Dunnett’s test for mean comparisons, utilizing one-way ANOVA. In the chick chorioallantoic membrane assay, both angiogenic score and branching points were evaluated. Notably, CI exhibited noteworthy antiangiogenic effects. In the sponge implantation technique, CI at specified dosages resulted in a substantial reduction in sponge weights, the formation of new vessels, and hemoglobin levels. The antiangiogenic effects were particularly pronounced with increasing doses. Furthermore, on endothelial cells, C. inerme demonstrated a dose-dependent decrease in migration, proliferation, and tube length, indicating potent antiangiogenic properties. In summary, this research underscores the considerable antiangiogenic potential of CI by various assays.

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Antiangiogenic potential of phytochemicals from Clerodendrum inerme (L.) Gaertn investigated through in silico and quantum computational methods

Yasmeen,

Chaudhary,

Khan

et al. 2024

Mol Divers

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In vitro Wound Healing Potential and Antimicrobial Activity of Clerodendrum Inerme Leave Extracts

Cited by 5 publications

References 20 publications

Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review

Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review

Anti-Angiogenic Effect of Clerodendreme inerme Leaves Extract

Antiangiogenic potential of phytochemicals from Clerodendrum inerme (L.) Gaertn investigated through in silico and quantum computational methods

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