In vitro α-glucosidase and α-amylase inhibition by aqueous, hydroalcoholic, and alcoholic extract of Euphorbia hirta L.

Sheliya, Manjur Ali; Begum, Rayhana; Pillai, Kolappa Krishna; Aeri, Vidhu; Mir, Showkat R.; Ali, Abuzer; Sharma, Manju

doi:10.4103/2394-6555.180156

Cited by 26 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study by Zorzin et al (2014), isopropanolic fractions and sub-fractions of E. dysenterica, showed a higher IC50 (between 8 and 128 µg/mL) than M. chamissois extract (Zorzin et al, 2014). The aqueous extract of Euphorbia hirta demonstrated an IC50 of 180.1 µg/mL (Sheliya et al, 2016). Therefore, AEMC, although less effective than the standard, displayed considerable alfa-amylase inhibitory activity, showing great potential for other studies to elucidate the compound(s) responsible for this action.…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales mentioning

confidence: 98%

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract

Gomes¹,

Martins²,

Silva³

et al. 2021

BLACPMA

View full text Add to dashboard Cite

The objective of this study was to evaluate biological and phytochemical properties of the aqueous extract from the leaves of Miconia chamissois Naudin (AEMC). Phytochemical properties were assessed by analyzing the chromatographic profile and the polyphenol content of AEMC. Biological properties evaluation was conducted based on cytotoxicity assay and by evaluating the antioxidant, antimicrobial, and enzymatic inhibition activities. Results indicated the presence of phytochemicals in AEMC such as flavonoids and polyphenols, including rutin, isoquercitrin and vitexin derivatives. AEMC showed antioxidant activity, which may be attributed to the high polyphenolic content. Moreover, AEMC demonstrated in vitro enzyme inhibition activity against tyrosinase and alpha-amylase, as well as showed low cytotoxicity. On the other hand, AEMC exhibited weak antimicrobial activity against S. aureus and C. albicans. Thus, AEMC is a promising alternative in search of potential drugs for the treatment of diseases induced by oxidative stress and inflammation, conditions due to hyperpigmentation processes, such as melisma, as well as for diabetes.

show abstract

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales mentioning

confidence: 98%

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract

Gomes¹,

Martins²,

Silva³

et al. 2021

BLACPMA

View full text Add to dashboard Cite

show abstract

“…A double reciprocal plot was prepared using 1/V versus 1/S where V is the reaction velocity and S is the substrate concentration. The type (mode) of inhibition of the 3 extracts on α-amylase activity was determined by analysing the double reciprocal (Lineweaver-Burk) plot using Michaelis-Menten kinetics (Kaseem et al, 2013;Sheliya et al, 2016).…”

Section: Kinetics Of α-Amylase Inhibitionmentioning

confidence: 99%

In vitro antiglycation and hypoglycaemic effects of Syzygium cumini leaf extracts

Perera

Poongunran

Premadasa

et al. 2018

J. Natn. Sci. Foundation Sri Lanka

View full text Add to dashboard Cite

Glycation is a prime mechanism responsible for chronic diabetic complications, a process which is enhanced under hyperglycaemia. Natural inhibitors of protein glycation and those which can lower postprandial blood glucose elevation are of utmost importance in minimising the damage caused by diabetes. One objective of this study was to assess the in vitro inhibitory effects of Syzygium cumini (SC) leaf extracts on protein glycation and α-glucosidase activity. The other objective was to identify the type of inhibition on α-amylase activity. SC leaf powder was sequentially extracted with hexane (H), ethyl acetate (E), methanol (M) and water (W). In vitro inhibitory effects of extracts on protein glycation, α-amylase and α-glucosidase enzymes were measured. M and W were the major fractions recovered [50.74 and 27.94 % (w/w), respectively] while H was the smallest fraction [7.35 % (w/w)] out of total yield. All extracts inhibited fructosamine formation, protein glycation and protein crosslinking at 2 mgmL -1 . At 0.05 mgmL -1 , fructosamine formation was inhibited in the presence of E, M and W while there was no significant inhibition with H. At 0.1 mgmL -1 , antiglycation effect of the H extract was negligible while other extracts retained their effects. IC 50 values of H, E, M and W extracts against α-glucosidase were 7.89, 3.11, 0.86 and 0.69 µgmL -1 , respectively. A mixed type inhibitory effect was observed on α-amylase with E, M and W extracts. H extract did not inhibit α-amylase. In conclusion, the results provide evidence for antiglycation and hypoglycaemic effects of SC leaf extracts demonstrating better activities in E, M and W extracts.

show abstract

“…E. hirta is famous as an analgesic to treat rheumatism, toothache, severe headache, colic and pains during pregnancy and as an antidote and pain relief of snakebites and scorpion stings. Furthermore, in the treatment of diabetes, this plant was used as a folk medicine for a long time (Sheliya et al, 2016;Tran, Tran, Truong, & Le, 2020). In addition, recent pharmacological research revealed that E. hirta possess several pharmacological properties such as antidiabetic (Subramanian, Bhuvaneshwari, & Prasath, 2011), anticancer, antioxidant, and antiinflammatory (N. Sharma et al, 2014), anthelmintic, antidipsogenic, angiotensin-converting enzyme inhibitory, anti-arthritis, and galactogenic (Al-Snafi, 2017), wound healing potential (Tuhin et al, 2017), hepatoprotective (Tiwari, Mishra, Bhatt, & Chaudhary, 2015, antibacterial (Kader, Noor, Radzi, & Wahab, 2013), antianaphylactic (Youssouf et al, 2007 and anxiolytic (Xia et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Potential and Phytochemical Investigation of Medicinal Plant (Euphorbia Hirta Linn)

Asghar Ali,

Pulh,

Sajid

et al. 2023

Pak. J. Biotechnol

View full text Add to dashboard Cite

Euphorbia hirta linn (E. hirta) is a medicinal plant, also known as asthma weeds which are mainly used against human pathogenic diseases such as digestive tract problem, asthma, coughs, diarrhea, dysentery, typhoid fever, inflammation, chronic bronchitis, and other pulmonary disorders. The native of these plants is in Asia, Australia, and East and West Africa. In the present study antibacterial activities, antioxidant activities, and phytochemicals were estimated from 20% isopropanol and aqueous extract of different parts (leaf, fruit, stem, root) of E. hirta. The maximum antioxidant activity, Phenolic contents, and flavonoids showed 0.418 mg/ml in aqueous fruit extract, 0.176 and 0.43 mg/ml in aqueous leaf extract respectively. Some other bioactive compounds were also observed from both 20% extracts of different segments of E. hirta qualitatively. Furthermore, some biomolecules were estimated in higher amounts from E. hirta plant extracts as total sugar 0.168 mg/ml from the aqueous extract of the fruit, total protein 0.453mg/ml from isopropanol extract of the fruit, and the reducing sugar contents 0.08 mg/ml from aqueous root extract. Different parts of the understudy plant (E. hirta) extracts exhibited antibacterial activity against E. coli and K. pneumonia. Whereas only aqueous and isopropanol extract of root and stem and aqueous extract of fruit showed negative antibacterial activity against S. pneumonia. The result suggested that E. hirta may be used for the treatment of different infectious diseases due to the presence of different phytochemicals.

show abstract

In vitro α-glucosidase and α-amylase inhibition by aqueous, hydroalcoholic, and alcoholic extract of Euphorbia hirta L.

Cited by 26 publications

References 1 publication

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract

In vitro antiglycation and hypoglycaemic effects of Syzygium cumini leaf extracts

Antibacterial Potential and Phytochemical Investigation of Medicinal Plant (Euphorbia Hirta Linn)

Contact Info

Product

Resources

About