In Vivo [18F] FDG PET Imaging Reveals that p-Chloroamphetamine Neurotoxicity is Associated with Long-Term Cortical and Hippocampal Hypometabolism

Garcı́a-Garcı́a, Luis; Delgado, Mercedes; Alsayed, Ahmed; Bascuñana, Pablo; Rosa, Rubén Fernández de la; Bermejo-Bescós, Paloma; Martín‐Aragón, Sagrario; Pozo, Miguel A.

doi:10.1007/s11307-014-0794-4

Cited by 3 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To this aim, a small-animal dedicated hybrid scanner was used (Albira ARS, Oncovision, Valencia, Spain). The acquisition and imaging processing protocols have been previously described (García-García et al, 2014). Briefly, fasted rats (at least 12 h) were injected i.v.…”

Section: [ 18 F] Fdg Pet Imagingmentioning

confidence: 99%

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Shiha

Cristóbal

Delgado

et al. 2015

Brain Research Bulletin

Self Cite

View full text Add to dashboard Cite

Section: [ 18 F] Fdg Pet Imagingmentioning

confidence: 99%

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Shiha

Cristóbal

Delgado

et al. 2015

Brain Research Bulletin

Self Cite

View full text Add to dashboard Cite

“…Glial fibrillary acidic protein immunohistochemistry was carried out as previously reported by García-García et al. ( 2015 ) with minor modifications. The samples were fixed with 4% formaldehyde, washed, permeabilized with tris-buffered saline (TBS)/0.1% Tween 20 and blocked with 5% albumin dissolved in TBS.…”

Section: Methodsmentioning

confidence: 99%

Nanotechnology-based drug delivery of ropinirole for Parkinson’s disease

et al. 2017

Self Cite

View full text Add to dashboard Cite

A new drug delivery system is developed for ropinirole (RP) for the treatment of Parkinson's disease (PD) consisting of biodegradable poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs). The formulation selected was prepared with 8 mg RP and 50 mg PLGA 502. This formulation exhibited mean encapsulation efficiency of 74.8 ± 8.2%, mean particle size lower than 155 nm, the zeta potential of -14.25 ± 0.43 mV and zero-order in vitro release of RP (14.13 ± 0.17 μg/h/10 mg NPs) for 5 d. Daily doses of the neurotoxin rotenone (2 mg/kg) given i.p. to male Wistar rats induced neuronal and behavioral changes similar to those of PD. Once neurodegeneration was established (15 d) animals received RP in saline (1 mg/kg/d for 35 d) or encapsulated within PLGA NPs (amount of NPs equivalent to 1 mg/kg/d RP every 3 d for 35 d). Brain histology and immunochemistry (Nissl-staining, glial fibrillary acidic protein and tyrosine hydroxylase immunohistochemistry) and behavioral testing (catalepsy, akinesia, rotarod and swim test) showed that RP-loaded PLGA NPs were able to revert PD-like symptoms of neurodegeneration in the animal model assayed.

show abstract

Acute effects of para-chloroamphetamine on testosterone and markers of apoptosis in seminiferous epithelium of prepubertal male rats

Rivas¹,

Flores

Pérez³

et al. 2022

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

In Vivo [18F] FDG PET Imaging Reveals that p-Chloroamphetamine Neurotoxicity is Associated with Long-Term Cortical and Hippocampal Hypometabolism

Abstract: Overall, [(18)F] FDG PET revealed that the reduction of the brain metabolic activity induced by PCA is related to 5-HT axon terminal lesion, with no apparent affectation of neuronal viability.

Cited by 3 publications

References 39 publications

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Nanotechnology-based drug delivery of ropinirole for Parkinson’s disease

Acute effects of para-chloroamphetamine on testosterone and markers of apoptosis in seminiferous epithelium of prepubertal male rats

Contact Info

Product

Resources

About