In vivo 31P nuclear magnetic resonance spectroscopy of osteosarcoma

Mooyaart, E. L.; Kamman, R. L.; Boeve, W. J.

doi:10.1007/978-1-4615-3518-8_3

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…The characteristic 31 P spectral pattern of tumors seen in vitro, which, unlike the majority of diseases studied is not related to bioenergetics but is instead related to modifications of intermediates of phospholipid metabolism, al-so has been found in vivo. The pattern consists of relatively high concentrations of Etn-P and Cho-P. Several general reviews have been published on the subject [167][168][169][170][171][172], as well as papers on specific tumor histopathologies (lymphomas [173][174][175][176]; sarcomas [177][178][179][180]; and breast [69,[181][182][183][184][185], lung [186,187], brain [188], prostate [189], and liver carcinomas [190]) as well as follow up of anticancer treatment [191][192][193][194][195].…”

Section: In Vivo Markers Of Disease Using 31 P Mrsmentioning

confidence: 99%

In Vivo Measurement of Phosphorous Markers of Disease

Arias‐Mendoza

Brown²

2004

Disease Markers

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Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) has been utilized to study energy, carbohydrate, and phospholipid metabolism in vitro and in vivo in live tissues non-invasively. Despite its lack of sensitivity, its application has extended to in situ human tissues and organs since proper signal localization was devised. Follow-up of phosphocreatine in neuromuscular diseases and schizophrenia and follow-up of phospholipid-related molecules in tumors are described here to demonstrate the value of 31P-MRS as an imaging technique to determine in vivo markers of disease and in the diagnosis, prognosis, and follow-up of human diseases.

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